S100A4 and MYH10

Number of citations of the paper that reports this interaction (PubMedID 9405067)
0

Data Source:
HPRD (in vitro)

		S100A4	MYH10
Description		S100 calcium binding protein A4	myosin heavy chain 10
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Matrix Perinuclear Region Of Cytoplasm Extracellular Exosome	Stress Fiber Nucleus Cytoplasm Spindle Cytosol Plasma Membrane Brush Border Cell Cortex Cytoplasmic Side Of Plasma Membrane Cell Surface Membrane Myosin Complex Myosin II Complex Sarcoplasm Lamellipodium Axon Growth Cone Midbody Neuromuscular Junction Cleavage Furrow Myosin Filament Actomyosin Cell Projection Neuron Projection Neuronal Cell Body Dendritic Spine Extracellular Exosome Myosin II Filament Postsynaptic Actin Cytoskeleton Glutamatergic Synapse Supramolecular Fiber
	Molecular Function	RNA Binding Actin Binding Calcium Ion Binding Protein Binding Chemoattractant Activity Identical Protein Binding Metal Ion Binding Transition Metal Ion Binding Calcium-dependent Protein Binding RAGE Receptor Binding	Microfilament Motor Activity Nucleotide Binding Virus Receptor Activity Cytoskeletal Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding RNA Stem-loop Binding ADP Binding MRNA 5'-UTR Binding Actin Filament Binding
	Biological Process	Epithelial To Mesenchymal Transition Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Chemotaxis	Mitotic Cytokinesis In Utero Embryonic Development Neuron Migration Plasma Membrane Repair Cardiac Septum Development Exocytosis Substrate-dependent Cell Migration, Cell Extension Nuclear Migration Cell Adhesion Axonogenesis Axon Guidance Brain Development Heart Development Adult Heart Development Regulation Of Cell Shape Fourth Ventricle Development Lateral Ventricle Development Third Ventricle Development Cerebellar Purkinje Cell Layer Development Actin Cytoskeleton Organization Actin Filament-based Movement Myofibril Assembly Actomyosin Structure Organization Neuron Projection Development Aorta Development Symbiont Entry Into Host Cell Positive Regulation Of Protein Secretion Neuromuscular Process Controlling Balance Cardiac Myofibril Assembly Ventricular Cardiac Muscle Cell Development Cardiac Muscle Cell Proliferation Retina Development In Camera-type Eye Coronary Vasculature Development Postsynaptic Actin Cytoskeleton Organization
Pathways			EPHA-mediated growth cone collapse Sema4D induced cell migration and growth-cone collapse RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs
Drugs		Trifluoperazine Copper
Diseases
GWAS		Pulse pressure ( 30578418)	Type 2 diabetes ( 30130595)
Interacting Genes		29 interacting genes: ACTA1 ANXA2 BAG6 CCN3 CEP20 EGFR FCGR3A HSPB1 IFNB1 MDM2 METAP2 MYH10 MYH2 MYH4 MYH9 PPFIBP1 RHOU S100A1 S100B S100P SEPTIN2 SEPTIN6 SEPTIN7 SMAD3 SRPK2 TP53 TPM2 TPM3 UNC119	14 interacting genes: ANXA1 APC BCAP31 DUX4 ECPAS FXR1 FXR2 MYH9 PBX1 PTEN S100A4 YWHAE YWHAG ZNF512B
Entrez ID		6275	4628
HPRD ID		15914	01178
Ensembl ID		ENSG00000196154	ENSG00000133026
Uniprot IDs		P26447	A0A8I5KZ38 G1UI33 P35580
PDB IDs		1M31 2LNK 2MRD 2Q91 3C1V 3CGA 3KO0 3M0W 3ZWH 4CFQ 4CFR 4ETO 4HSZ 5LPU 6T58 7PSP 7PSQ	4PD3
Enriched GO Terms of Interacting Partners?		Cytoplasm Identical Protein Binding Cleavage Furrow Actin Filament Binding Myosin II Complex Myosin Filament Spindle Sperm Annulus Stress Fiber Microfilament Motor Activity Cytoskeleton-dependent Cytokinesis Supramolecular Fiber Cytosol S100 Protein Binding Cell Division Site Septin Ring Septin Complex Cytoskeletal Motor Activity Myosin Complex Regulation Of Developmental Process Actin Filament-based Movement Regulation Of Cell Shape Cellular Response To Actinomycin D Myosin II Filament Calcium-dependent Protein Binding Cadherin Binding Cytoskeleton Supramolecular Fiber Organization Midbody Response To Actinomycin D Muscle Thin Filament Tropomyosin Muscle Contraction Regulation Of Protein Kinase C Signaling Cellular Response To UV-C Actin Binding ADP Binding Actin-mediated Cell Contraction Negative Regulation Of Protein Catabolic Process Regulation Of Cell Morphogenesis Regulation Of Plasma Membrane Repair Muscle System Process Nucleotide Binding Cell Adhesion Cellular Developmental Process System Process Actin Cytoskeleton Regulation Of Protein Localization Sarcomere Positive Regulation Of Gene Expression Regulation Of Protein Processing	Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Protein Targeting Dentate Gyrus Development Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Cytosol Positive Regulation Of Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Primary Metabolic Process Lateral Plasma Membrane Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Gene Expression Cytoplasmic Stress Granule Protein Localization To Endoplasmic Reticulum Cytoplasm Translation Regulator Activity Regulation Of Macromolecule Biosynthetic Process RNA Binding Regulation Of Cell Differentiation Regulation Of Mitotic Cell Cycle Negative Regulation Of Protein Phosphorylation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Toll-like Receptor Signaling Pathway Meiotic Spindle Organization Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Phosphorylation Positive Regulation Of Signal Transduction Plasma Membrane Bounded Cell Projection Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Catabolic Process Positive Regulation Of Transcription By RNA Polymerase II Mononuclear Cell Differentiation Regulation Of Wound Healing Regulation Of Mitotic Cell Cycle Phase Transition Molecular Function Inhibitor Activity Negative Regulation Of Metabolic Process Cytoplasmic Translational Initiation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Microfilament Motor Activity Positive Regulation Of Translation Regulation Of G1/S Transition Of Mitotic Cell Cycle
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