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TPI1 and TERF1
Number of citations of the paper that reports this interaction (PubMedID
21044950
)
82
Data Source:
BioGRID
(two hybrid)
TPI1
TERF1
Description
triosephosphate isomerase 1
telomeric repeat binding factor 1
Image
GO Annotations
Cellular Component
Extracellular Space
Nucleus
Cytoplasm
Cytosol
Extracellular Exosome
Chromosome, Telomeric Region
Nuclear Telomere Cap Complex
Fibrillar Center
Nucleus
Nucleoplasm
Chromosome
Nucleolus
Cytoplasm
Spindle
Cytoskeleton
Nuclear Body
Shelterin Complex
Molecular Function
Triose-phosphate Isomerase Activity
Protein Binding
Methylglyoxal Synthase Activity
Lyase Activity
Isomerase Activity
Ubiquitin Protein Ligase Binding
Protein Homodimerization Activity
DNA Binding
Double-stranded Telomeric DNA Binding
Telomerase Activity
Protein Binding
Microtubule Binding
DNA Binding, Bending
Telomeric DNA Binding
Identical Protein Binding
Protein Homodimerization Activity
Ankyrin Repeat Binding
G-rich Strand Telomeric DNA Binding
Biological Process
Glucose Metabolic Process
Gluconeogenesis
Glycolytic Process
Methylglyoxal Biosynthetic Process
Glycerol Catabolic Process
Glyceraldehyde-3-phosphate Metabolic Process
Glyceraldehyde-3-phosphate Biosynthetic Process
Canonical Glycolysis
Telomere Maintenance
Telomere Maintenance Via Telomerase
Negative Regulation Of DNA Replication
Response To Xenobiotic Stimulus
Telomere Capping
Positive Regulation Of Telomere Maintenance
Negative Regulation Of Telomere Maintenance Via Telomerase
Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication
Meiotic Telomere Clustering
Cell Division
Telomeric D-loop Disassembly
T-circle Formation
Negative Regulation Of Telomere Maintenance Via Telomere Lengthening
Positive Regulation Of Shelterin Complex Assembly
Negative Regulation Of Establishment Of Protein Localization To Telomere
Negative Regulation Of Establishment Of RNA Localization To Telomere
Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere
Negative Regulation Of Telomeric D-loop Disassembly
Pathways
Glycolysis
Gluconeogenesis
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Telomere Extension By Telomerase
Polymerase switching on the C-strand of the telomere
Processive synthesis on the C-strand of the telomere
Telomere C-strand (Lagging Strand) Synthesis
Telomere C-strand synthesis initiation
Removal of the Flap Intermediate from the C-strand
DNA Damage/Telomere Stress Induced Senescence
Inhibition of DNA recombination at telomere
Drugs
Zinc
N-Hydroxy-4-phosphonobutanamide
2-Phosphoglycolic Acid
Phosphoglycolohydroxamic Acid
3-(2-Benzothiazolylthio)-1-Propanesulfonic Acid
[2(Formyl-Hydroxy-Amino)-Ethyl]-Phosphonic Acid
5-fluorotryptophan
2-Carboxyethylphosphonic Acid
tert-butanol
Dihydroxyacetone phosphate
1,4-Dithiothreitol
3-phospho-D-glyceric acid
3-(BUTYLSULPHONYL)-PROPANOIC ACID
Artenimol
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Diseases
Anemia due to disorders of glycolytic enzymes, including: Hexokinase (HK) deficiency; Phosphoglycerate kinase 1 (PGK1) deficiency; Triose-phosphate isomerase (TPI) deficiency; Glucose phosphate isomerase (GPI) deficiency; Bisphosphoglycerate mutase (BPGM) deficiency
GWAS
Blood protein levels (
30072576
)
Refractive error (
32231278
)
Age at first sexual intercourse (
34211149
)
Crohn's disease (
22412388
)
Leukocyte telomere length (
31171785
)
Telomere length (
33941849
)
Interacting Genes
18 interacting genes:
APP
BDKRB2
CCL11
CDKN2A
CEBPA
CFL1
DDX24
EGFR
HTR2C
LIPT1
MAPK6
PCNA
POT1
SETDB1
SP1
TERF1
UCHL5
YWHAQ
212 interacting genes:
ACAT2
ACOT7
ACY1
AFAP1L2
AHCY
AK1
AKR1A1
ALDOA
AMPD2
AMPH
ANXA2
ANXA5
ANXA8L1
APEX1
ARHGDIA
ARHGEF3
ARPP21
ASS1
ATM
BCL7B
BIN2
BLM
BRAF
C12orf43
C1orf35
CALD1
CAPNS1
CASP7
CCDC9
CDC6
CDK1
CEP85
CFL1
CKB
CORO1B
CPNE3
CRYBB1
CRYM
DBN1
DBNL
DCX
DDX19B
DDX21
DDX23
DDX24
DDX39A
DLG5
DNAAF11
DNAJB1
DNPH1
DPP3
DPYSL3
EEF1D
EIF4B
ENO2
EPB41L1
EPHX2
EVL
FANCD2
FBP1
FBXO4
FEN1
FES
FKBP8
GAMT
GAPDH
GIT1
GNL3L
GNMT
GSS
H1-1
HCLS1
HDGFL2
HEXIM1
HEXIM2
HGD
HMGN3
HMGN4
HMOX1
HNMT
HOXA3
HSP90AB1
HSPA6
IPO5
JSRP1
KCTD7
KDM1A
KEAP1
KIFBP
KLHDC4
KPNB1
LASP1
LDHA
LDHB
LRSAM1
LYAR
MAP4
MAP7
MAPK12
MAPRE1
MCM2
MDH1
MISP
MSN
MT1X
MVK
NAP1L1
NBN
NEFL
NEK7
NME1
NME2
NOL12
NOL3
NRIP1
NUDCD2
NUDT14
NUMA1
NXNL1
OCM2
OGFR
OGT
PA2G4
PACSIN2
PAFAH1B3
PAGE2
PAICS
PAK4
PCLAF
PCP4
PEPD
PFKP
PFN2
PGD
PGLS
PGM1
PGM2
PINX1
PKM
PNMT
POT1
PPM1G
PRDX1
PRDX6
PRKCB
PTMA
PTPN5
RBMY1A1
RECQL4
RIC8A
RLIM
RNF10
RPAP3
RPL19
RTN3
RTN4
SALL1
SARS1
SBDS
SENP8
SET
SH3BP1
SH3GL2
SH3GL3
SHFL
SIRPD
SKP1
SMAD9
SMARCC2
SNCG
SOAT1
SP100
SRM
SRSF6
STUB1
SULT1C2
SUPT5H
SYK
TALDO1
TBC1D10A
TBCD
TBL1X
TCIRG1
TERT
THG1L
TINAG
TINF2
TKT
TMSB10
TMSB4Y
TNKS
TNKS2
TNPO2
TOMM34
TPI1
TRIM16
TRIP10
TRMT1
TUBB2A
TUBB3
TUBB4B
UBE2M
UTP14A
WARS1
WDR4
WFS1
YWHAG
ZBTB16
ZC3H18
ZFP36L1
ZHX1
ZNF790
Entrez ID
7167
7013
HPRD ID
01833
02975
Ensembl ID
ENSG00000111669
ENSG00000147601
Uniprot IDs
P60174
Q53HE2
V9HWK1
A0A7I2V5T5
A0A7I2YQE7
P54274
PDB IDs
1HTI
1KLG
1KLU
1WYI
2IAM
2IAN
2JK2
2VOM
4BR1
4E41
4POC
4POD
4UNK
4UNL
4ZVJ
6C2G
6D43
6NLH
6UP1
6UP5
6UP8
6UPF
7RDE
7SX1
7T0Q
7UXB
7UXV
9F69
9FFC
1BA5
1H6O
1ITY
1IV6
1W0T
3BQO
3L82
5HKP
5WIR
5XUP
8F0A
8F0U
8F1T
8F1U
8F21
8F26
8OX1
8W8G
Enriched GO Terms of Interacting Partners
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Intracellular Signaling Cassette
Regulation Of Cellular Response To Stress
Intracellular Signal Transduction
Telomere Maintenance
Regulation Of DNA Replication
Positive Regulation Of DNA Metabolic Process
Telomere Organization
Shelterin Complex
Regulation Of Developmental Process
Regulation Of Proteolysis
Positive Regulation Of Developmental Process
Cellular Response To Hydrogen Peroxide
Nuclear Telomere Cap Complex
Telomeric D-loop Disassembly
G-rich Strand Telomeric DNA Binding
Positive Regulation Of Telomere Maintenance
Telomeric Loop Disassembly
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Telomere Capping
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Dendritic Spine Maintenance
Protein-containing Complex
Regulation Of DNA Repair
Regulation Of DNA Biosynthetic Process
Chromatin Binding
Morphogenesis Of An Epithelial Fold
DNA Biosynthetic Process
Positive Regulation Of Protein Metabolic Process
Regulation Of DNA Metabolic Process
Regulation Of DNA Strand Elongation
Positive Regulation Of Organelle Organization
Negative Regulation Of Metabolic Process
Cellular Response To Chemical Stress
Response To Hydrogen Peroxide
Negative Regulation Of Cell Development
Positive Regulation Of Metabolic Process
Learning Or Memory
Positive Regulation Of Chromosome Organization
Cellular Response To Oxygen-containing Compound
Cellular Response To Reactive Oxygen Species
Regulation Of Telomere Maintenance
Identical Protein Binding
Negative Regulation Of Telomere Maintenance Via Telomerase
Response To Amino Acid
Telomere Maintenance Via Telomerase
Regulation Of Multicellular Organismal Process
Positive Regulation Of Cell Motility
Cognition
Positive Regulation Of Locomotion
Positive Regulation Of Amyloid Precursor Protein Catabolic Process
Cytosol
Cytoplasm
Extracellular Exosome
Identical Protein Binding
Protein Binding
Nucleobase-containing Compound Metabolic Process
Nicotinamide Nucleotide Metabolic Process
Telomere Maintenance
Chromosome, Telomeric Region
Nucleobase-containing Small Molecule Metabolic Process
Purine-containing Compound Metabolic Process
Telomere Organization
Cadherin Binding
Nucleus
Negative Regulation Of Telomere Maintenance
Purine Nucleotide Metabolic Process
ADP Metabolic Process
Regulation Of Telomere Maintenance Via Telomerase
Regulation Of Chromosome Organization
Positive Regulation Of Chromosome Organization
Nucleoside Diphosphate Metabolic Process
Glycolytic Process
Pyruvate Metabolic Process
Positive Regulation Of Cellular Component Organization
Regulation Of Cellular Component Organization
ADP Catabolic Process
Nucleotide Metabolic Process
Purine Ribonucleoside Diphosphate Catabolic Process
Regulation Of Telomere Maintenance Via Telomere Lengthening
Ribonucleoside Diphosphate Catabolic Process
Nucleoside Phosphate Metabolic Process
Ficolin-1-rich Granule Lumen
Nucleoside Diphosphate Catabolic Process
Ribonucleoside Diphosphate Metabolic Process
Nucleoside Phosphate Catabolic Process
RNA Binding
Phosphate-containing Compound Metabolic Process
Microtubule Cytoskeleton Organization
Negative Regulation Of DNA Metabolic Process
Regulation Of Telomere Maintenance
Negative Regulation Of Telomere Maintenance Via Telomere Lengthening
Purine Nucleotide Catabolic Process
Protein Localization To Organelle
Positive Regulation Of Protein-containing Complex Assembly
Cytoskeleton
Positive Regulation Of Organelle Organization
Organelle Organization
Catalytic Activity
Small Molecule Metabolic Process
Organophosphate Catabolic Process
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Tagcloud (Intersection)
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