TPI1 and CCL11

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		TPI1	CCL11
Gene Name		triosephosphate isomerase 1	chemokine (C-C motif) ligand 11
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Cytosol Extracellular Vesicular Exosome	Extracellular Region Extracellular Space
	Molecular Function	Triose-phosphate Isomerase Activity Protein Binding	Protein Binding Chemokine Activity
	Biological Process	Carbohydrate Metabolic Process Glucose Metabolic Process Gluconeogenesis Glycolytic Process Pentose-phosphate Shunt Multicellular Organismal Development Pathogenesis Glyceraldehyde-3-phosphate Metabolic Process Small Molecule Metabolic Process	Positive Regulation Of Endothelial Cell Proliferation Chronic Inflammatory Response Mast Cell Chemotaxis Protein Phosphorylation Cellular Calcium Ion Homeostasis Chemotaxis Inflammatory Response Immune Response Cytoskeleton Organization Actin Filament Organization Cell Adhesion Signal Transduction Regulation Of Cell Shape Response To Radiation Response To Virus Positive Regulation Of Cell Migration Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Rac GTPase Activity Positive Regulation Of Angiogenesis Eosinophil Chemotaxis Branching Involved In Mammary Gland Duct Morphogenesis Mammary Duct Terminal End Bud Growth ERK1 And ERK2 Cascade Response To Interleukin-4
Pathways		Gluconeogenesis Glucose metabolism Myoclonic epilepsy of Lafora Glycogen storage diseases Glycolysis Metabolism of carbohydrates	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS			Crohn's disease ( 22412388) Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		15 interactors: APP CCL11 CDKN2A CFL1 DDX24 EGFR LIPT1 MAPK6 PCNA POT1 SETDB1 SP1 TERF1 UCHL5 YWHAQ	7 interactors: ACKR2 ACKR4 CCR3 CCR5 DPP4 NUDT3 TPI1
Entrez ID		7167	6356
HPRD ID		01833	03098
Ensembl ID		ENSG00000111669	ENSG00000172156
Uniprot IDs		P60174 Q53HE2	P51671 Q6I9T4
PDB IDs		1HTI 1WYI 2IAM 2IAN 2JK2 2VOM 4BR1 4E41	1EOT 2EOT
Enriched GO Terms of Interacting Partners?		Telomere Maintenance Via Telomere Lengthening Regulation Of DNA Replication Positive Regulation Of Organelle Organization Negative Regulation Of Telomere Maintenance Via Telomerase Homeostatic Process Telomere Maintenance Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Negative Regulation Of Telomerase Activity Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Organ Development Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Hydrolase Activity Positive Regulation Of Cell Cycle Regulation Of Catalytic Activity Cellular Protein Modification Process Regulation Of Telomerase Activity Mitotic Cell Cycle Process Developmental Process Cellular Metabolic Process Regulation Of Telomere Maintenance Mitotic Cell Cycle Negative Regulation Of Catalytic Activity RNA-dependent DNA Replication Negative Regulation Of DNA Biosynthetic Process Regulation Of Mitotic Cell Cycle Positive Regulation Of DNA Metabolic Process Cell Cycle G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cellular Metabolic Process Morphogenesis Of An Epithelial Fold Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Organelle Organization Positive Regulation Of Catalytic Activity Positive Regulation Of Cytoskeleton Organization System Development Chromosome Organization Cell Cycle Process Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process MAPK Cascade Cellular Protein Metabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of DNA Biosynthetic Process Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of DNA Replication Chemotaxis	Chemokine-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Locomotion Cellular Response To Cytokine Stimulus Chemotaxis Response To Cytokine Cellular Defense Response G-protein Coupled Receptor Signaling Pathway Inflammatory Response Diphosphoinositol Polyphosphate Catabolic Process Diadenosine Polyphosphate Catabolic Process Organophosphate Catabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Response To External Stimulus Cellular Response To Organic Substance Negative Regulation Of Extracellular Matrix Organization Negative Regulation Of Extracellular Matrix Disassembly Cytosolic Calcium Ion Homeostasis Immune System Process Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cell-cell Adhesion Mediated By Integrin Cellular Calcium Ion Homeostasis Sarcoplasmic Reticulum Calcium Ion Transport Calcium Ion Homeostasis Response To Organic Substance Dendritic Cell Chemotaxis Receptor-mediated Endocytosis Immune Response Defense Response Cellular Metal Ion Homeostasis Neutrophil Activation Cellular Cation Homeostasis Response To Cholesterol Cellular Ion Homeostasis Dendritic Cell Migration Pentose-phosphate Shunt Glyceraldehyde-3-phosphate Metabolic Process Cell Surface Receptor Signaling Pathway Metal Ion Homeostasis Leukocyte Activation Regulation Of Extracellular Matrix Disassembly Cellular Chemical Homeostasis Signaling Viral Process Response To Stress Glucose 6-phosphate Metabolic Process Release Of Sequestered Calcium Ion Into Cytosol Ion Homeostasis Cell Communication Nucleotide Metabolic Process
Tagcloud ?		achieve anxa2 biomarkers ccsnk2a1 considerably cscs dataset depicting deprived differentiated eif4e eliminates gapdh glioma hnrnpk hprd hsp90beta1 hspa8 hypoxic ipa micro namely nampt pgk1 proteomic reviews u87 undifferentiated vimentin	biopsy ccl5 cells chemokines chemotaxins compare cx3cl1 determined distribution epithelial il immunohistochemistry included intraepithelial investigate mast method might migrate migration mucosa nasal normal objective obtained polyps regulated result specimens
Tagcloud (Difference) ?		achieve anxa2 biomarkers ccsnk2a1 considerably cscs dataset depicting deprived differentiated eif4e eliminates gapdh glioma hnrnpk hprd hsp90beta1 hspa8 hypoxic ipa micro namely nampt pgk1 proteomic reviews u87 undifferentiated vimentin	biopsy ccl5 cells chemokines chemotaxins compare cx3cl1 determined distribution epithelial il immunohistochemistry included intraepithelial investigate mast method might migrate migration mucosa nasal normal objective obtained polyps regulated result specimens
Tagcloud (Intersection) ?