TPI1

Description		triosephosphate isomerase 1
Image
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Triose-phosphate Isomerase Activity Protein Binding Methylglyoxal Synthase Activity Lyase Activity Isomerase Activity Ubiquitin Protein Ligase Binding Protein Homodimerization Activity
	Biological Process	Glucose Metabolic Process Gluconeogenesis Glycolytic Process Methylglyoxal Biosynthetic Process Glycerol Catabolic Process Glyceraldehyde-3-phosphate Metabolic Process Glyceraldehyde-3-phosphate Biosynthetic Process Canonical Glycolysis
Pathways		Glycolysis Gluconeogenesis
Drugs		Zinc N-Hydroxy-4-phosphonobutanamide 2-Phosphoglycolic Acid Phosphoglycolohydroxamic Acid 3-(2-Benzothiazolylthio)-1-Propanesulfonic Acid [2(Formyl-Hydroxy-Amino)-Ethyl]-Phosphonic Acid 5-fluorotryptophan 2-Carboxyethylphosphonic Acid tert-butanol Dihydroxyacetone phosphate 1,4-Dithiothreitol 3-phospho-D-glyceric acid 3-(BUTYLSULPHONYL)-PROPANOIC ACID Artenimol Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		Anemia due to disorders of glycolytic enzymes, including: Hexokinase (HK) deficiency; Phosphoglycerate kinase 1 (PGK1) deficiency; Triose-phosphate isomerase (TPI) deficiency; Glucose phosphate isomerase (GPI) deficiency; Bisphosphoglycerate mutase (BPGM) deficiency
GWAS		Blood protein levels ( 30072576) Refractive error ( 32231278)
Interacting Genes		18 interacting genes: APP BDKRB2 CCL11 CDKN2A CEBPA CFL1 DDX24 EGFR HTR2C LIPT1 MAPK6 PCNA POT1 SETDB1 SP1 TERF1 UCHL5 YWHAQ
Entrez ID		7167
HPRD ID		01833
Ensembl ID		ENSG00000111669
Uniprot IDs		P60174 Q53HE2 V9HWK1
PDB IDs		1HTI 1KLG 1KLU 1WYI 2IAM 2IAN 2JK2 2VOM 4BR1 4E41 4POC 4POD 4UNK 4UNL 4ZVJ 6C2G 6D43 6NLH 6UP1 6UP5 6UP8 6UPF 7RDE 7SX1 7T0Q 7UXB 7UXV 9F69 9FFC
Enriched GO Terms of Interacting Partners?		Intracellular Signaling Cassette Regulation Of Cellular Response To Stress Intracellular Signal Transduction Telomere Maintenance Regulation Of DNA Replication Positive Regulation Of DNA Metabolic Process Telomere Organization Shelterin Complex Regulation Of Developmental Process Regulation Of Proteolysis Positive Regulation Of Developmental Process Cellular Response To Hydrogen Peroxide Nuclear Telomere Cap Complex Telomeric D-loop Disassembly G-rich Strand Telomeric DNA Binding Positive Regulation Of Telomere Maintenance Telomeric Loop Disassembly Positive Regulation Of Nucleobase-containing Compound Metabolic Process Telomere Capping Negative Regulation Of Macromolecule Metabolic Process Regulation Of Dendritic Spine Maintenance Protein-containing Complex Regulation Of DNA Repair Regulation Of DNA Biosynthetic Process Chromatin Binding Morphogenesis Of An Epithelial Fold DNA Biosynthetic Process Positive Regulation Of Protein Metabolic Process Regulation Of DNA Metabolic Process Regulation Of DNA Strand Elongation Positive Regulation Of Organelle Organization Negative Regulation Of Metabolic Process Cellular Response To Chemical Stress Response To Hydrogen Peroxide Negative Regulation Of Cell Development Positive Regulation Of Metabolic Process Learning Or Memory Positive Regulation Of Chromosome Organization Cellular Response To Oxygen-containing Compound Cellular Response To Reactive Oxygen Species Regulation Of Telomere Maintenance Identical Protein Binding Negative Regulation Of Telomere Maintenance Via Telomerase Response To Amino Acid Telomere Maintenance Via Telomerase Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Motility Cognition Positive Regulation Of Locomotion Positive Regulation Of Amyloid Precursor Protein Catabolic Process
Tagcloud ?