XPO1 and RAN

Number of citations of the paper that reports this interaction (PubMedID 9323133)
0

Data Source:
HPRD (in vitro)

		XPO1	RAN
Description		exportin 1	RAN, member RAS oncogene family
Image
GO Annotations	Cellular Component	Kinetochore Nucleus Nuclear Envelope Annulate Lamellae Nucleoplasm Nucleolus Cytoplasm Cytosol Cajal Body Membrane Nuclear Membrane Protein-containing Complex Ribonucleoprotein Complex	Chromatin Male Germ Cell Nucleus Manchette Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Nucleolus Cytoplasm Centriole Cytosol Membrane Midbody Protein-containing Complex Sperm Flagellum Melanosome RNA Nuclear Export Complex Recycling Endosome Extracellular Exosome Flemming Body
	Molecular Function	RNA Binding Nuclear Export Signal Receptor Activity Protein Binding Protein Domain Specific Binding Small GTPase Binding DNA-binding Transcription Factor Binding	Nucleotide Binding Magnesium Ion Binding Chromatin Binding RNA Binding GTPase Activity G Protein Activity Nuclear Export Signal Receptor Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Protein Domain Specific Binding Protein-containing Complex Binding Cadherin Binding Dynein Intermediate Chain Binding Metal Ion Binding Protein Heterodimerization Activity Importin-alpha Family Protein Binding Pre-miRNA Binding
	Biological Process	Ribosomal Subunit Export From Nucleus Ribosomal Large Subunit Export From Nucleus Ribosomal Small Subunit Export From Nucleus Negative Regulation Of Transcription By RNA Polymerase II MRNA Export From Nucleus Protein Export From Nucleus Intracellular Protein Transport Nucleocytoplasmic Transport Response To Xenobiotic Stimulus Regulation Of Centrosome Duplication Protein Transport Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Localization To Nucleus Regulation Of Protein Catabolic Process Ribosome Biogenesis Regulation Of Protein Export From Nucleus MRNA Transport Cellular Response To Triglyceride Cellular Response To Salt	Ribosomal Subunit Export From Nucleus Ribosomal Large Subunit Export From Nucleus Ribosomal Small Subunit Export From Nucleus Mitotic Sister Chromatid Segregation Mitotic Cell Cycle Glycolytic Process DNA Metabolic Process Protein Import Into Nucleus Protein Export From Nucleus Nucleocytoplasmic Transport Mitotic Spindle Organization Spermatid Development Intracellular Protein Localization Protein Transport Viral Process Hippocampus Development Actin Cytoskeleton Organization Protein-containing Complex Localization Pre-miRNA Export From Nucleus Positive Regulation Of Protein Import Into Nucleus GTP Metabolic Process Cell Division SnRNA Import Into Nucleus Cellular Response To Mineralocorticoid Stimulus Protein Localization To Nucleolus
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Rev-mediated nuclear export of HIV RNA NEP/NS2 Interacts with the Cellular Export Machinery Downregulation of TGF-beta receptor signaling Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Deactivation of the beta-catenin transactivating complex HuR (ELAVL1) binds and stabilizes mRNA RHO GTPases Activate Formins MAPK6/MAPK4 signaling Mitotic Prometaphase Cyclin A/B1/B2 associated events during G2/M transition Estrogen-dependent nuclear events downstream of ESR-membrane signaling EML4 and NUDC in mitotic spindle formation Heme signaling NPAS4 regulates expression of target genes Maturation of hRSV A proteins Transcriptional and post-translational regulation of MITF-M expression and activity	Rev-mediated nuclear export of HIV RNA Regulation of cholesterol biosynthesis by SREBP (SREBF) NEP/NS2 Interacts with the Cellular Export Machinery Nuclear import of Rev protein MicroRNA (miRNA) biogenesis Transcriptional regulation by small RNAs tRNA processing in the nucleus Postmitotic nuclear pore complex (NPC) reformation Postmitotic nuclear pore complex (NPC) reformation
Drugs		Selinexor	Guanosine-5'-Diphosphate
Diseases
GWAS		Atrial fibrillation ( 29892015) Eosinophil count ( 27863252 32888494) Erectile dysfunction ( 30583798) Mean reticulocyte volume ( 32888494) Monocyte count ( 32888494) Neutrophil count ( 32888494) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 28714469) Urinary sodium excretion ( 31409800) White blood cell count ( 32888494)
Interacting Genes		86 interacting genes: ABL1 ADAR AGFG1 AHR ANP32A ANP32B APC ATF2 BECN1 BIRC5 BRCA2 CCND1 CDC25A CDC42 CDCA4 CDK1 CDKN1B CEBPA CHEK1 CHORDC1 CIITA CRK DDX3X DESI1 DR1 E2F4 E2F5 EIF4E EIF5A ERF FBXO7 FILNC1 FOXO4 HDAC3 HNF4A HSPA9 HSPB1 IRF5 KIF17 LINC01554 LRPPRC MAPK6 NF2 NMD3 NOSIP NPM1 NUCB1 NUCB2 NUP153 NUP214 NUP50 NUP62 NXF3 NXT1 OGT ORC1 PHAX PHB1 PKIA RAD51 RAN RANBP2 RANBP3 RCC1 RCN2 RGS14 RIC8A RPS6KB1 SERPINB1 SERTAD2 SIRT2 SMAD1 SMARCB1 SMURF1 SMURF2 SNUPN SOX2 STAT1 STRADA SUMO2 TERF2IP TERT TOP2A TOP2B TP53 TP73	62 interacting genes: ABL1 ADRB2 AR ASAP2 BCAR1 BIRC5 BMPR1B CEP126 CSE1L DUX4 EP300 FNDC3B FOXP1 GADD45G GIT1 IPO11 IPO13 IPO4 IPO5 IPO7 IPO8 IPO9 KPNB1 MBP MSL1 NEK9 NR3C1 NSMF NUP153 NUP50 NUTF2 NXF1 NXT1 PAK4 PARP10 PTMA RANBP1 RANBP10 RANBP2 RANBP3 RANBP9 RANGAP1 RANGRF RCC1 RGPD5 RPL7 SMAD1 SMAD2 SMARCB1 SMURF2 SPAG8 SSRP1 SUMO2 TGFBR1 TNPO1 VRK2 VRK3 XPO1 XPO4 XPO5 XPO7 XPOT
Entrez ID		7514	5901
HPRD ID		03975	03109
Ensembl ID		ENSG00000082898	ENSG00000132341
Uniprot IDs		A0A7I2V2Y6 A0A7I2V461 A0A7I2V6B9 B3KWD0 O14980	B4DV51 P62826
PDB IDs		1W9C 2L1L 3GB8 4BSM 4BSN 5DIS 6TVO 7B51 9B62	1I2M 1IBR 1K5D 1K5G 1QBK 1RRP 2MMC 2MMG 2N1B 3CH5 3EA5 3GJ0 3GJ3 3GJ4 3GJ5 3GJ6 3GJ7 3GJ8 3GJX 3NBY 3NBZ 3NC0 3NC1 3ZJY 4C0Q 4GMX 4GPT 4HAT 4HAU 4HAV 4HAW 4HAX 4HAY 4HAZ 4HB0 4HB2 4HB3 4HB4 4OL0 4WVF 5CIQ 5CIT 5CIW 5CJ2 5CLL 5CLQ 5DH9 5DHA 5DHF 5DI9 5DIF 5DIS 5DLQ 5FYQ 5JLJ 5UWH 5UWI 5UWJ 5UWO 5UWP 5UWQ 5UWR 5UWS 5UWT 5UWU 5UWW 5YRO 5YST 5YSU 5YTB 5ZPU 6A38 6A3A 6A3B 6A3C 6A3E 6CIT 6KFT 6LQ9 6M60 6M6X 6Q82 6Q84 6TVO 6X2M 6X2O 6X2P 6X2R 6X2S 6X2U 6X2V 6X2W 6X2X 6X2Y 6XJP 6XJR 6XJS 6XJT 6XJU 7B51 7CND 7DBG 7L5E 7MNP 7MNQ 7MNR 7MNS 7MNT 7MNU 7MNV 7MNW 7MNX 7MNY 7MNZ 7MO0 7MO1 7MO2 7MO3 7MO4 7MO5 7YPZ 8HQ3 8HQ4 8HQ5 8HQ6 8HUF 8HUG 8ITV 8UX1 9B62
Enriched GO Terms of Interacting Partners?		Nuclear Transport Nucleocytoplasmic Transport Nuclear Export Nucleoplasm Nucleus Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Cytoplasm Intracellular Transport Protein Export From Nucleus Regulation Of Primary Metabolic Process RNA Transport Establishment Of Localization In Cell Protein Import Into Nucleus Import Into Nucleus Cellular Localization Intracellular Protein Transport Protein-containing Complex Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Programmed Cell Death Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cell Cycle Nuclear Pore Establishment Of Protein Localization To Organelle Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Transport Positive Regulation Of Mitotic Cell Cycle Intracellular Signal Transduction Protein Localization To Nucleus Cytosol Positive Regulation Of Metabolic Process RNA Export From Nucleus Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Cycle Positive Regulation Of RNA Metabolic Process Chromatin Binding Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Protein Localization To Organelle Negative Regulation Of Mitotic Cell Cycle DNA Binding MRNA Transport Regulation Of Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of DNA-templated Transcription	Small GTPase Binding Nuclear Transport Nucleocytoplasmic Transport Nuclear Pore Protein Import Into Nucleus Import Into Nucleus Intracellular Protein Transport Protein Localization To Nucleus Nucleus Nuclear Export Nuclear Envelope Establishment Of Localization In Cell Intracellular Transport Protein Transport Nucleoplasm Cellular Localization Protein Export From Nucleus Nuclear Import Signal Receptor Activity Protein Localization To Organelle Establishment Of Protein Localization To Organelle Establishment Of Protein Localization Intracellular Protein Localization RNA Transport Cytoplasm Nuclear Export Signal Receptor Activity Nuclear Membrane Nucleobase-containing Compound Transport Nuclear Localization Sequence Binding Cytosol Ribosomal Protein Import Into Nucleus Regulation Of Nucleocytoplasmic Transport MRNA Transport RNA Export From Nucleus Protein-containing Complex SMAD Binding NLS-bearing Protein Import Into Nucleus Protein Binding Nuclear Inclusion Body Homomeric SMAD Protein Complex Cytoplasmic Periphery Of The Nuclear Pore Complex Response To Growth Factor Mitotic Spindle Organization I-SMAD Binding Regulation Of Intracellular Transport Cellular Response To Growth Factor Stimulus Negative Regulation Of RNA Export From Nucleus SUMO Ligase Complex Nuclear Pore Cytoplasmic Filaments Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Cell Cycle
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