XPO1 and SNUPN

Number of citations of the paper that reports this interaction (PubMedID 10209022)
73

Data Source:
HPRD (in vitro, in vivo)

		XPO1	SNUPN
Description		exportin 1	snurportin 1
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GO Annotations	Cellular Component	Kinetochore Nucleus Nuclear Envelope Annulate Lamellae Nucleoplasm Nucleolus Cytoplasm Cytosol Cajal Body Membrane Nuclear Membrane Protein-containing Complex Ribonucleoprotein Complex	Nucleus Nuclear Pore Nucleoplasm Cytoplasm Cytosol Plasma Membrane NLS-dependent Protein Nuclear Import Complex
	Molecular Function	RNA Binding Nuclear Export Signal Receptor Activity Protein Binding Protein Domain Specific Binding Small GTPase Binding DNA-binding Transcription Factor Binding	RNA Cap Binding RNA Binding Protein Binding Nuclear Import Signal Receptor Activity
	Biological Process	Ribosomal Subunit Export From Nucleus Ribosomal Large Subunit Export From Nucleus Ribosomal Small Subunit Export From Nucleus Negative Regulation Of Transcription By RNA Polymerase II MRNA Export From Nucleus Protein Export From Nucleus Intracellular Protein Transport Nucleocytoplasmic Transport Response To Xenobiotic Stimulus Regulation Of Centrosome Duplication Protein Transport Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Localization To Nucleus Regulation Of Protein Catabolic Process Ribosome Biogenesis Regulation Of Protein Export From Nucleus MRNA Transport Cellular Response To Triglyceride Cellular Response To Salt	RNA Import Into Nucleus Protein Import Into Nucleus Cytoskeleton Organization Protein Complex Oligomerization Protein Tetramerization SnRNA Import Into Nucleus
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Rev-mediated nuclear export of HIV RNA NEP/NS2 Interacts with the Cellular Export Machinery Downregulation of TGF-beta receptor signaling Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Deactivation of the beta-catenin transactivating complex HuR (ELAVL1) binds and stabilizes mRNA RHO GTPases Activate Formins MAPK6/MAPK4 signaling Mitotic Prometaphase Cyclin A/B1/B2 associated events during G2/M transition Estrogen-dependent nuclear events downstream of ESR-membrane signaling EML4 and NUDC in mitotic spindle formation Heme signaling NPAS4 regulates expression of target genes Maturation of hRSV A proteins Transcriptional and post-translational regulation of MITF-M expression and activity	snRNP Assembly
Drugs		Selinexor
Diseases
GWAS		Atrial fibrillation ( 29892015) Eosinophil count ( 27863252 32888494) Erectile dysfunction ( 30583798) Mean reticulocyte volume ( 32888494) Monocyte count ( 32888494) Neutrophil count ( 32888494) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 28714469) Urinary sodium excretion ( 31409800) White blood cell count ( 32888494)	Appendicular lean mass ( 33097823) Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		86 interacting genes: ABL1 ADAR AGFG1 AHR ANP32A ANP32B APC ATF2 BECN1 BIRC5 BRCA2 CCND1 CDC25A CDC42 CDCA4 CDK1 CDKN1B CEBPA CHEK1 CHORDC1 CIITA CRK DDX3X DESI1 DR1 E2F4 E2F5 EIF4E EIF5A ERF FBXO7 FILNC1 FOXO4 HDAC3 HNF4A HSPA9 HSPB1 IRF5 KIF17 LINC01554 LRPPRC MAPK6 NF2 NMD3 NOSIP NPM1 NUCB1 NUCB2 NUP153 NUP214 NUP50 NUP62 NXF3 NXT1 OGT ORC1 PHAX PHB1 PKIA RAD51 RAN RANBP2 RANBP3 RCC1 RCN2 RGS14 RIC8A RPS6KB1 SERPINB1 SERTAD2 SIRT2 SMAD1 SMARCB1 SMURF1 SMURF2 SNUPN SOX2 STAT1 STRADA SUMO2 TERF2IP TERT TOP2A TOP2B TP53 TP73	15 interacting genes: DBN1 DDX20 ENO2 GCNT3 KPNB1 MEX3B PAFAH1B2 PEX5 RNF126 RPL17 SMN1 SNRPB TNNT3 XPO1 ZPR1
Entrez ID		7514	10073
HPRD ID		03975	07441
Ensembl ID		ENSG00000082898	ENSG00000169371
Uniprot IDs		A0A7I2V2Y6 A0A7I2V461 A0A7I2V6B9 B3KWD0 O14980	O95149
PDB IDs		1W9C 2L1L 3GB8 4BSM 4BSN 5DIS 6TVO 7B51 9B62	1XK5 2P8Q 2Q5D 2QNA 3GB8 3GJX 3LWW 3NBY 3NBZ 3NC0 5DIS
Enriched GO Terms of Interacting Partners?		Nuclear Transport Nucleocytoplasmic Transport Nuclear Export Nucleoplasm Nucleus Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Cytoplasm Intracellular Transport Protein Export From Nucleus Regulation Of Primary Metabolic Process RNA Transport Establishment Of Localization In Cell Protein Import Into Nucleus Import Into Nucleus Cellular Localization Intracellular Protein Transport Protein-containing Complex Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Programmed Cell Death Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cell Cycle Nuclear Pore Establishment Of Protein Localization To Organelle Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Transport Positive Regulation Of Mitotic Cell Cycle Intracellular Signal Transduction Protein Localization To Nucleus Cytosol Positive Regulation Of Metabolic Process RNA Export From Nucleus Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Cycle Positive Regulation Of RNA Metabolic Process Chromatin Binding Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Protein Localization To Organelle Negative Regulation Of Mitotic Cell Cycle DNA Binding MRNA Transport Regulation Of Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of DNA-templated Transcription	Gemini Of Cajal Bodies SMN-Sm Protein Complex Growth Cone Spliceosomal SnRNP Assembly Cajal Body SMN Complex Cytoplasm Regulation Of Nucleocytoplasmic Transport Cerebral Cortex Neuron Differentiation Perikaryon Regulation Of Intracellular Protein Transport Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway RNA Splicing Cerebral Cortex Cell Migration Cytosol Negative Regulation Of ERBB Signaling Pathway Cell Cortex Positive Regulation Of Dendritic Spine Development Protein-containing Complex Forebrain Neuron Differentiation Positive Regulation Of Protein Import Into Nucleus MRNA Processing Telencephalon Cell Migration Forebrain Cell Migration Negative Regulation Of Core Promoter Binding Spliceosomal Complex Assembly Protein-RNA Complex Assembly Positive Regulation Of Calcium-dependent ATPase Activity DNA Endoreduplication Pre-mRNA Catabolic Process Acetylgalactosaminyl-O-glycosyl-glycoprotein Beta-1,6-N-acetylglucosaminyltransferase Activity Regulation Of Dendritic Spine Development Protein Domain Specific Binding Protein Monoubiquitination Cell Communication By Chemical Coupling Synaptic Membrane RNA Binding Nuclear Membrane Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Cajal-Retzius Cell Differentiation Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Intracellular Transport Peroxisome Membrane Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding U2 SnRNP Binding Cellular Response To Triglyceride N-acetyllactosaminide Beta-1,6-N-acetylglucosaminyltransferase Activity Beta-1,3-galactosyl-O-glycosyl-glycoprotein Beta-1,6-N-acetylglucosaminyltransferase Activity
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