XPO1 and NUP153

Number of citations of the paper that reports this interaction (PubMedID 10202161)
91

Data Source:
HPRD (in vitro)

		XPO1	NUP153
Description		exportin 1	nucleoporin 153
Image
GO Annotations	Cellular Component	Kinetochore Nucleus Nuclear Envelope Annulate Lamellae Nucleoplasm Nucleolus Cytoplasm Cytosol Cajal Body Membrane Nuclear Membrane Protein-containing Complex Ribonucleoprotein Complex	Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Nucleolus Cytosol Membrane Nuclear Membrane Nuclear Periphery Nuclear Inclusion Body Host Cell Nuclear Pore Nuclear Basket
	Molecular Function	RNA Binding Nuclear Export Signal Receptor Activity Protein Binding Protein Domain Specific Binding Small GTPase Binding DNA-binding Transcription Factor Binding	DNA Binding Protein Binding Nuclear Localization Sequence Binding Zinc Ion Binding Structural Constituent Of Nuclear Pore Identical Protein Binding Protein-membrane Adaptor Activity Metal Ion Binding Molecular Condensate Scaffold Activity
	Biological Process	Ribosomal Subunit Export From Nucleus Ribosomal Large Subunit Export From Nucleus Ribosomal Small Subunit Export From Nucleus Negative Regulation Of Transcription By RNA Polymerase II MRNA Export From Nucleus Protein Export From Nucleus Intracellular Protein Transport Nucleocytoplasmic Transport Response To Xenobiotic Stimulus Regulation Of Centrosome Duplication Protein Transport Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Localization To Nucleus Regulation Of Protein Catabolic Process Ribosome Biogenesis Regulation Of Protein Export From Nucleus MRNA Transport Cellular Response To Triglyceride Cellular Response To Salt	RNA Export From Nucleus Protein Import Into Nucleus Nucleocytoplasmic Transport Protein Transport Symbiont Entry Into Host Cell Negative Regulation Of RNA Export From Nucleus MRNA Transport Nuclear Pore Complex Assembly Viral Penetration Into Host Nucleus Amyloid Fibril Formation
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Rev-mediated nuclear export of HIV RNA NEP/NS2 Interacts with the Cellular Export Machinery Downregulation of TGF-beta receptor signaling Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Deactivation of the beta-catenin transactivating complex HuR (ELAVL1) binds and stabilizes mRNA RHO GTPases Activate Formins MAPK6/MAPK4 signaling Mitotic Prometaphase Cyclin A/B1/B2 associated events during G2/M transition Estrogen-dependent nuclear events downstream of ESR-membrane signaling EML4 and NUDC in mitotic spindle formation Heme signaling NPAS4 regulates expression of target genes Maturation of hRSV A proteins Transcriptional and post-translational regulation of MITF-M expression and activity	ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs		Selinexor
Diseases
GWAS		Atrial fibrillation ( 29892015) Eosinophil count ( 27863252 32888494) Erectile dysfunction ( 30583798) Mean reticulocyte volume ( 32888494) Monocyte count ( 32888494) Neutrophil count ( 32888494) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 28714469) Urinary sodium excretion ( 31409800) White blood cell count ( 32888494)	Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 18391951) Obesity-related traits ( 23251661)
Interacting Genes		86 interacting genes: ABL1 ADAR AGFG1 AHR ANP32A ANP32B APC ATF2 BECN1 BIRC5 BRCA2 CCND1 CDC25A CDC42 CDCA4 CDK1 CDKN1B CEBPA CHEK1 CHORDC1 CIITA CRK DDX3X DESI1 DR1 E2F4 E2F5 EIF4E EIF5A ERF FBXO7 FILNC1 FOXO4 HDAC3 HNF4A HSPA9 HSPB1 IRF5 KIF17 LINC01554 LRPPRC MAPK6 NF2 NMD3 NOSIP NPM1 NUCB1 NUCB2 NUP153 NUP214 NUP50 NUP62 NXF3 NXT1 OGT ORC1 PHAX PHB1 PKIA RAD51 RAN RANBP2 RANBP3 RCC1 RCN2 RGS14 RIC8A RPS6KB1 SERPINB1 SERTAD2 SIRT2 SMAD1 SMARCB1 SMURF1 SMURF2 SNUPN SOX2 STAT1 STRADA SUMO2 TERF2IP TERT TOP2A TOP2B TP53 TP73	29 interacting genes: APC BRCA1 CEBPA CLK1 DNMT3A DYNLT1 FILNC1 GRSF1 IPO5 KPNA2 KPNB1 MAPK1 MAPK14 MAPK3 NUP62 NXF1 NXF2 PTGER4 RAN SENP2 SMAD2 SMAD3 TNPO1 TPR TRN-GTT2-7 XPO1 XPO5 XPO7 XPOT
Entrez ID		7514	9972
HPRD ID		03975	04899
Ensembl ID		ENSG00000082898	ENSG00000124789
Uniprot IDs		A0A7I2V2Y6 A0A7I2V461 A0A7I2V6B9 B3KWD0 O14980	P49790
PDB IDs		1W9C 2L1L 3GB8 4BSM 4BSN 5DIS 6TVO 7B51 9B62	2EBQ 2EBR 2EBV 2GQE 4U0C 4U0D 5TSV 5TSX 6AYA 8CKY 8CL0 9CNU
Enriched GO Terms of Interacting Partners?		Nuclear Transport Nucleocytoplasmic Transport Nuclear Export Nucleoplasm Nucleus Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Cytoplasm Intracellular Transport Protein Export From Nucleus Regulation Of Primary Metabolic Process RNA Transport Establishment Of Localization In Cell Protein Import Into Nucleus Import Into Nucleus Cellular Localization Intracellular Protein Transport Protein-containing Complex Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Programmed Cell Death Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cell Cycle Nuclear Pore Establishment Of Protein Localization To Organelle Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Transport Positive Regulation Of Mitotic Cell Cycle Intracellular Signal Transduction Protein Localization To Nucleus Cytosol Positive Regulation Of Metabolic Process RNA Export From Nucleus Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Cycle Positive Regulation Of RNA Metabolic Process Chromatin Binding Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Protein Localization To Organelle Negative Regulation Of Mitotic Cell Cycle DNA Binding MRNA Transport Regulation Of Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of DNA-templated Transcription	Nuclear Transport Nucleocytoplasmic Transport Nuclear Pore RNA Transport Nuclear Export RNA Export From Nucleus Nucleobase-containing Compound Transport Protein Transport Establishment Of Protein Localization Regulation Of Intracellular Transport Protein Localization To Nucleus Intracellular Protein Transport Protein Import Into Nucleus Nucleoplasm Import Into Nucleus Protein Export From Nucleus Intracellular Transport Nuclear Export Signal Receptor Activity Positive Regulation Of Protein Import Into Nucleus Intracellular Protein Localization Establishment Of Localization In Cell RNA Import Into Nucleus Nuclear Import Signal Receptor Activity Regulation Of Nucleocytoplasmic Transport Nuclear Localization Sequence Binding Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport Nuclear Envelope MRNA Transport RNA Binding Cellular Localization Positive Regulation Of Intracellular Transport Regulation Of Intracellular Protein Transport Regulation Of Cellular Localization Nuclear Membrane Positive Regulation Of Intracellular Protein Transport Small GTPase Binding Cellular Response To Tumor Necrosis Factor Positive Regulation Of Protein Localization To Nucleus Nucleus Establishment Of Protein Localization To Organelle Phosphatase Binding Response To Tumor Necrosis Factor Regulation Of Ossification MAP Kinase Activity RNA Nuclear Export Complex Pre-miRNA Export From Nucleus Regulation Of Cytoskeleton Organization MRNA Export From Nucleus Cytoplasm
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