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XPO1 and NUP62
Number of citations of the paper that reports this interaction (PubMedID
10330396
)
63
Data Source:
HPRD
(in vitro, in vivo)
XPO1
NUP62
Description
exportin 1
nucleoporin 62
Image
GO Annotations
Cellular Component
Kinetochore
Nucleus
Nuclear Envelope
Annulate Lamellae
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Cajal Body
Membrane
Nuclear Membrane
Protein-containing Complex
Ribonucleoprotein Complex
Spindle Pole
Nucleus
Nuclear Envelope
Nuclear Pore
Nucleoplasm
Cytoplasm
Centrosome
Cytoskeleton
Nuclear Membrane
Nuclear Pore Central Transport Channel
Mitotic Spindle
Flemming Body
Ribonucleoprotein Complex
Molecular Function
RNA Binding
Nuclear Export Signal Receptor Activity
Protein Binding
Protein Domain Specific Binding
Small GTPase Binding
DNA-binding Transcription Factor Binding
Chromatin Binding
Protein Binding
Phospholipid Binding
Structural Constituent Of Nuclear Pore
Signaling Receptor Complex Adaptor Activity
Hsp70 Protein Binding
SH2 Domain Binding
Ubiquitin Binding
PTB Domain Binding
Hsp90 Protein Binding
Biological Process
Ribosomal Subunit Export From Nucleus
Ribosomal Large Subunit Export From Nucleus
Ribosomal Small Subunit Export From Nucleus
Negative Regulation Of Transcription By RNA Polymerase II
MRNA Export From Nucleus
Protein Export From Nucleus
Intracellular Protein Transport
Nucleocytoplasmic Transport
Response To Xenobiotic Stimulus
Regulation Of Centrosome Duplication
Protein Transport
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Protein Localization To Nucleus
Regulation Of Protein Catabolic Process
Ribosome Biogenesis
Regulation Of Protein Export From Nucleus
MRNA Transport
Cellular Response To Triglyceride
Cellular Response To Salt
RNA Export From Nucleus
Protein Import Into Nucleus
Nucleocytoplasmic Transport
Mitotic Metaphase Chromosome Alignment
Centrosome Cycle
Mitotic Centrosome Separation
Cell Surface Receptor Signaling Pathway
Negative Regulation Of Cell Population Proliferation
Regulation Of Signal Transduction
Protein Transport
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of Mitotic Nuclear Division
Positive Regulation Of DNA-templated Transcription
Regulation Of Ras Protein Signal Transduction
Negative Regulation Of Ras Protein Signal Transduction
Positive Regulation Of Centriole Replication
MRNA Transport
Regulation Of Mitotic Spindle Organization
Cellular Senescence
Centriole Assembly
Positive Regulation Of Mitotic Cytokinetic Process
Positive Regulation Of Protein Localization To Centrosome
Pathways
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Rev-mediated nuclear export of HIV RNA
NEP/NS2 Interacts with the Cellular Export Machinery
Downregulation of TGF-beta receptor signaling
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Deactivation of the beta-catenin transactivating complex
HuR (ELAVL1) binds and stabilizes mRNA
RHO GTPases Activate Formins
MAPK6/MAPK4 signaling
Mitotic Prometaphase
Cyclin A/B1/B2 associated events during G2/M transition
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
EML4 and NUDC in mitotic spindle formation
Heme signaling
NPAS4 regulates expression of target genes
Maturation of hRSV A proteins
Transcriptional and post-translational regulation of MITF-M expression and activity
ISG15 antiviral mechanism
Transport of the SLBP independent Mature mRNA
Transport of the SLBP Dependant Mature mRNA
Transport of Mature mRNA Derived from an Intronless Transcript
Transport of Mature mRNA derived from an Intron-Containing Transcript
Rev-mediated nuclear export of HIV RNA
Transport of Ribonucleoproteins into the Host Nucleus
NS1 Mediated Effects on Host Pathways
Viral Messenger RNA Synthesis
NEP/NS2 Interacts with the Cellular Export Machinery
Regulation of Glucokinase by Glucokinase Regulatory Protein
Nuclear import of Rev protein
Vpr-mediated nuclear import of PICs
IPs transport between nucleus and cytosol
IP3 and IP4 transport between cytosol and nucleus
IP6 and IP7 transport between cytosol and nucleus
snRNP Assembly
SUMOylation of DNA damage response and repair proteins
SUMOylation of ubiquitinylation proteins
Nuclear Pore Complex (NPC) Disassembly
Regulation of HSF1-mediated heat shock response
SUMOylation of SUMOylation proteins
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA replication proteins
SUMOylation of DNA replication proteins
Transcriptional regulation by small RNAs
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)
tRNA processing in the nucleus
HCMV Early Events
HCMV Late Events
Postmitotic nuclear pore complex (NPC) reformation
SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs
Selinexor
Diseases
GWAS
Atrial fibrillation (
29892015
)
Eosinophil count (
27863252
32888494
)
Erectile dysfunction (
30583798
)
Mean reticulocyte volume (
32888494
)
Monocyte count (
32888494
)
Neutrophil count (
32888494
)
Sum eosinophil basophil counts (
27863252
)
Systemic lupus erythematosus (
28714469
)
Urinary sodium excretion (
31409800
)
White blood cell count (
32888494
)
Interacting Genes
86 interacting genes:
ABL1
ADAR
AGFG1
AHR
ANP32A
ANP32B
APC
ATF2
BECN1
BIRC5
BRCA2
CCND1
CDC25A
CDC42
CDCA4
CDK1
CDKN1B
CEBPA
CHEK1
CHORDC1
CIITA
CRK
DDX3X
DESI1
DR1
E2F4
E2F5
EIF4E
EIF5A
ERF
FBXO7
FILNC1
FOXO4
HDAC3
HNF4A
HSPA9
HSPB1
IRF5
KIF17
LINC01554
LRPPRC
MAPK6
NF2
NMD3
NOSIP
NPM1
NUCB1
NUCB2
NUP153
NUP214
NUP50
NUP62
NXF3
NXT1
OGT
ORC1
PHAX
PHB1
PKIA
RAD51
RAN
RANBP2
RANBP3
RCC1
RCN2
RGS14
RIC8A
RPS6KB1
SERPINB1
SERTAD2
SIRT2
SMAD1
SMARCB1
SMURF1
SMURF2
SNUPN
SOX2
STAT1
STRADA
SUMO2
TERF2IP
TERT
TOP2A
TOP2B
TP53
TP73
88 interacting genes:
ABI2
ADAM15
AGR3
ARFIP2
ATF7IP2
ATXN7
BFSP1
BLOC1S6
C14orf119
C1orf216
CAVIN3
CCDC121
CCDC146
CCDC150
CCHCR1
CENPU
CEP57L1
CLIC1
CRCT1
DDX3X
DGCR6
DPPA3
DRC12
DTNB
DYNLT1
FABP3
GOPC
GORASP2
GTF2E2
HAUS1
HGS
HSF2
HSF4
IDH1
IFT20
IFT25
IK
IKBIP
IPO5
ISCU
KANSL1
KIFC3
KLHL32
KPNA1
KPNA2
KPNB1
KRT1
KRT20
KRT3
KRT6A
KRT6B
KRT75
LMO2
LNX1
MUC1
MXD3
MYO15B
NUP153
NUP54
NUP58
NUP98
NUTF2
NXF1
NXF2
OGT
OIP5
OTUD6A
PBX2
PELI2
PIN1
PTMA
RANBP2
SMARCA2
SMARCE1
SNAPC5
SP1
SSC5D
SUOX
THAP1
TLE4
TRAF3
TRIML2
TXLNA
TXN
USHBP1
WASHC3
XPO1
XPO6
Entrez ID
7514
23636
HPRD ID
03975
05782
Ensembl ID
ENSG00000082898
ENSG00000213024
Uniprot IDs
A0A7I2V2Y6
A0A7I2V461
A0A7I2V6B9
B3KWD0
O14980
P37198
PDB IDs
1W9C
2L1L
3GB8
4BSM
4BSN
5DIS
6TVO
7B51
9B62
5IJN
5IJO
7PER
7R5J
7R5K
Enriched GO Terms of Interacting Partners
?
Nuclear Transport
Nucleocytoplasmic Transport
Nuclear Export
Nucleoplasm
Nucleus
Regulation Of Cell Cycle
Regulation Of Mitotic Cell Cycle
Regulation Of Cell Cycle Process
Regulation Of Cell Cycle Phase Transition
Cytoplasm
Intracellular Transport
Protein Export From Nucleus
Regulation Of Primary Metabolic Process
RNA Transport
Establishment Of Localization In Cell
Protein Import Into Nucleus
Import Into Nucleus
Cellular Localization
Intracellular Protein Transport
Protein-containing Complex
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Programmed Cell Death
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Cell Cycle
Nuclear Pore
Establishment Of Protein Localization To Organelle
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Metabolic Process
Regulation Of Apoptotic Process
Positive Regulation Of RNA Biosynthetic Process
Nucleobase-containing Compound Transport
Positive Regulation Of Mitotic Cell Cycle
Intracellular Signal Transduction
Protein Localization To Nucleus
Cytosol
Positive Regulation Of Metabolic Process
RNA Export From Nucleus
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Cell Cycle
Positive Regulation Of RNA Metabolic Process
Chromatin Binding
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Protein Localization To Organelle
Negative Regulation Of Mitotic Cell Cycle
DNA Binding
MRNA Transport
Regulation Of Attachment Of Spindle Microtubules To Kinetochore
Positive Regulation Of DNA-templated Transcription
Nuclear Transport
Nucleocytoplasmic Transport
Nuclear Localization Sequence Binding
Nuclear Pore
NLS-bearing Protein Import Into Nucleus
RNA Transport
Protein Import Into Nucleus
Import Into Nucleus
Nuclear Export
MRNA Transport
Intracellular Transport
Nuclear Import Signal Receptor Activity
Protein Localization To Nucleus
Protein Transport
Establishment Of Protein Localization
Structural Constituent Of Nuclear Pore
Intermediate Filament Organization
Nuclear Membrane
Nucleobase-containing Compound Transport
Nuclear Inclusion Body
Protein Binding
Intermediate Filament Cytoskeleton Organization
Structural Constituent Of Skin Epidermis
Intermediate Filament-based Process
Intracellular Protein Transport
Cellular Localization
Protein Localization To Organelle
Establishment Of Localization In Cell
Establishment Of Protein Localization To Organelle
Supramolecular Fiber Organization
Nuclear Envelope
Intracellular Protein Localization
Intracellular Transport Of Virus
Keratin Filament
Host Cell
NLS-dependent Protein Nuclear Import Complex
Cytoskeleton Organization
Small GTPase Binding
Intermediate Filament
Protein Export From Nucleus
Keratinization
Nuclear Pore Nuclear Basket
Regulation Of Nucleocytoplasmic Transport
Nuclear Pore Organization
Identical Protein Binding
RNA Export From Nucleus
Nucleus Organization
Organelle Organization
Ribosomal Protein Import Into Nucleus
Viral Penetration Into Host Nucleus
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