TNNT2 and TNNI3

Number of citations of the paper that reports this interaction (PMID 12840750)
160

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		TNNT2	TNNI3
Gene Name		troponin T type 2 (cardiac)	troponin I type 3 (cardiac)
Image
Gene Ontology Annotations	Cellular Component	Cytosol Troponin Complex Striated Muscle Thin Filament Sarcomere	Cytosol Troponin Complex Sarcomere
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Tropomyosin Binding ATPase Activity Troponin C Binding Troponin I Binding	Actin Binding Protein Binding Calcium Channel Inhibitor Activity Protein Kinase Binding Protein Domain Specific Binding Troponin C Binding Troponin T Binding Metal Ion Binding Calcium-dependent Protein Binding
	Biological Process	Regulation Of Muscle Contraction Regulation Of Heart Contraction Metabolic Process Muscle Filament Sliding Negative Regulation Of ATPase Activity Positive Regulation Of ATPase Activity Sarcomere Organization Response To Calcium Ion Atrial Cardiac Muscle Tissue Morphogenesis Ventricular Cardiac Muscle Tissue Morphogenesis	Vasculogenesis Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Cellular Calcium Ion Homeostasis Regulation Of Smooth Muscle Contraction Heart Development Muscle Filament Sliding Negative Regulation Of ATPase Activity Ventricular Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction
Pathways		Striated Muscle Contraction	Striated Muscle Contraction
Drugs			N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide
Diseases
GWAS		Cardiac Troponin-T levels ( 23247143)
Protein-Protein Interactions		10 interactors: APP KDM1A MAP3K5 MORF4L2 NOTCH3 PRKCA TNNC1 TNNI1 TNNI3 TPM1	14 interactors: ACTA1 LYST PAPPA PKD2 PKD2L1 PRKCA RCAN3 TNNC1 TNNC2 TNNI3K TNNT1 TNNT2 TRIM55 TRIM63
Entrez ID		7139	7137
HPRD ID		01844	11769
Ensembl ID		ENSG00000118194	ENSG00000129991
Uniprot IDs		P45379 Q15607	P19429 Q6FGX2
PDB IDs		1J1D 1J1E	1J1D 1J1E 1LXF 1MXL 1OZS 2KGB 2KRD 2L1R
Enriched GO Terms of Interacting Partners?		Actin-myosin Filament Sliding Muscle Filament Sliding Ventricular Cardiac Muscle Tissue Morphogenesis Actin-mediated Cell Contraction Regulation Of Muscle Contraction Ventricular Cardiac Muscle Tissue Development Cardiac Muscle Tissue Morphogenesis Muscle Tissue Morphogenesis Actin Filament-based Movement Muscle Organ Morphogenesis Cardiac Ventricle Morphogenesis Cardiac Ventricle Development Cardiac Chamber Development Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Cardiovascular System Development Regulation Of ATPase Activity Cardiac Muscle Tissue Development Muscle Structure Development Cardiac Muscle Contraction Muscle Contraction Heart Morphogenesis Heart Contraction Organ Development Muscle System Process Muscle Organ Development Cellular Calcium Ion Homeostasis Striated Muscle Contraction Calcium Ion Homeostasis Striated Muscle Tissue Development Negative Regulation Of ATPase Activity Muscle Tissue Development Regulation Of Systemic Arterial Blood Pressure Movement Of Cell Or Subcellular Component Anatomical Structure Morphogenesis Cellular Metal Ion Homeostasis Blood Vessel Morphogenesis Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis System Development Neurological System Process Involved In Regulation Of Systemic Arterial Blood Pressure Heart Development Blood Vessel Development Cellular Chemical Homeostasis Regulation Of Blood Pressure Vasculature Development Ion Homeostasis Wound Healing Multicellular Organismal Development Anatomical Structure Development	Actin-myosin Filament Sliding Muscle Filament Sliding Actin-mediated Cell Contraction Actin Filament-based Movement Muscle Contraction Muscle System Process Regulation Of Muscle Contraction Skeletal Muscle Contraction Musculoskeletal Movement Movement Of Cell Or Subcellular Component Negative Regulation Of ATPase Activity Skeletal Muscle Adaptation Striated Muscle Contraction Actin Filament-based Process Muscle Tissue Development Positive Regulation Of Blood Vessel Endothelial Cell Migration Response To Inorganic Substance Detection Of Abiotic Stimulus Ion Homeostasis Response To Mechanical Stimulus Regulation Of ATPase Activity Heart Morphogenesis Response To Abiotic Stimulus Ventricular Cardiac Muscle Tissue Morphogenesis Regulation Of Blood Vessel Endothelial Cell Migration Detection Of Mechanical Stimulus Ventricular Cardiac Muscle Tissue Development Cardiac Muscle Tissue Morphogenesis Positive Regulation Of Endothelial Cell Migration Muscle Organ Development Positive Regulation Of Endothelial Cell Proliferation Cellular Calcium Ion Homeostasis Metanephric Cortex Development Metanephric Cortical Collecting Duct Development Regulation Of Muscle Filament Sliding Speed Positive Regulation Of Dense Core Granule Biogenesis Muscle Tissue Morphogenesis Calcium Ion Homeostasis Striated Muscle Tissue Development Muscle Organ Morphogenesis Cardiac Ventricle Morphogenesis Response To Metal Ion Myofibril Assembly Positive Regulation Of Epithelial Cell Migration Response To Interleukin-1 Regulation Of Endothelial Cell Proliferation Protein Kinase D Signaling Metanephric Smooth Muscle Tissue Development Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Skeletal Muscle Fiber Adaptation
Tagcloud ?		apposition axin2 bending bf bfr bones canonical compromised csa determinant epsilon histomorphometric hz ko littermate loaded loading mar mechanical mineral nfatc1 periosteal periosteum reductions tibia unloaded wnt wnt16 wt	activin bmp4 cardiomyogenic discovering dish enthusiasm exploiting hesc hipsc homeodomain homogeneity hpscs implement iroquois irx irx4 mlc2a mlc2v myosin offering passaged pluripotent repairing robustly standardization subpopulation technically tnnt2 troponin
Tagcloud (Difference) ?		apposition axin2 bending bf bfr bones canonical compromised csa determinant epsilon histomorphometric hz ko littermate loaded loading mar mechanical mineral nfatc1 periosteal periosteum reductions tibia unloaded wnt wnt16 wt	activin bmp4 cardiomyogenic discovering dish enthusiasm exploiting hesc hipsc homeodomain homogeneity hpscs implement iroquois irx irx4 mlc2a mlc2v myosin offering passaged pluripotent repairing robustly standardization subpopulation technically troponin
Tagcloud (Intersection) ?		tnnt2