TNNT2 and TNNI1

Number of citations of the paper that reports this interaction (PMID 15542288)
40

Data Source:
BioGRID (two hybrid)

		TNNT2	TNNI1
Gene Name		troponin T type 2 (cardiac)	troponin I type 1 (skeletal, slow)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Troponin Complex Striated Muscle Thin Filament Sarcomere	Cytosol Troponin Complex
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Tropomyosin Binding ATPase Activity Troponin C Binding Troponin I Binding	Actin Binding Metal Ion Binding
	Biological Process	Regulation Of Muscle Contraction Regulation Of Heart Contraction Metabolic Process Muscle Filament Sliding Negative Regulation Of ATPase Activity Positive Regulation Of ATPase Activity Sarcomere Organization Response To Calcium Ion Atrial Cardiac Muscle Tissue Morphogenesis Ventricular Cardiac Muscle Tissue Morphogenesis	Regulation Of Striated Muscle Contraction Muscle Filament Sliding Ventricular Cardiac Muscle Tissue Morphogenesis
Pathways		Striated Muscle Contraction	Striated Muscle Contraction
Drugs
Diseases
GWAS		Cardiac Troponin-T levels ( 23247143)
Protein-Protein Interactions		10 interactors: APP KDM1A MAP3K5 MORF4L2 NOTCH3 PRKCA TNNC1 TNNI1 TNNI3 TPM1	11 interactors: ACTA1 CCDC85B EIF3I MDFI PKD2L1 PNMA1 TNNC1 TNNT1 TNNT2 TRIM55 TRIM63
Entrez ID		7139	7135
HPRD ID		01844	01842
Ensembl ID		ENSG00000118194	ENSG00000159173
Uniprot IDs		P45379 Q15607	P19237
PDB IDs		1J1D 1J1E
Enriched GO Terms of Interacting Partners?		Actin-myosin Filament Sliding Muscle Filament Sliding Ventricular Cardiac Muscle Tissue Morphogenesis Actin-mediated Cell Contraction Regulation Of Muscle Contraction Ventricular Cardiac Muscle Tissue Development Cardiac Muscle Tissue Morphogenesis Muscle Tissue Morphogenesis Actin Filament-based Movement Muscle Organ Morphogenesis Cardiac Ventricle Morphogenesis Cardiac Ventricle Development Cardiac Chamber Development Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Cardiovascular System Development Regulation Of ATPase Activity Cardiac Muscle Tissue Development Muscle Structure Development Cardiac Muscle Contraction Muscle Contraction Heart Morphogenesis Heart Contraction Organ Development Muscle System Process Muscle Organ Development Cellular Calcium Ion Homeostasis Striated Muscle Contraction Calcium Ion Homeostasis Striated Muscle Tissue Development Negative Regulation Of ATPase Activity Muscle Tissue Development Regulation Of Systemic Arterial Blood Pressure Movement Of Cell Or Subcellular Component Anatomical Structure Morphogenesis Cellular Metal Ion Homeostasis Blood Vessel Morphogenesis Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis System Development Neurological System Process Involved In Regulation Of Systemic Arterial Blood Pressure Heart Development Blood Vessel Development Cellular Chemical Homeostasis Regulation Of Blood Pressure Vasculature Development Ion Homeostasis Wound Healing Multicellular Organismal Development Anatomical Structure Development	Actin-myosin Filament Sliding Muscle Filament Sliding Actin-mediated Cell Contraction Actin Filament-based Movement Muscle Contraction Muscle System Process Negative Regulation Of ATPase Activity Skeletal Muscle Adaptation Regulation Of Muscle Contraction Skeletal Muscle Contraction Actin Filament-based Process Regulation Of ATPase Activity Musculoskeletal Movement Ventricular Cardiac Muscle Tissue Morphogenesis Muscle Organ Development Ventricular Cardiac Muscle Tissue Development Cardiac Muscle Tissue Morphogenesis Striated Muscle Tissue Development Muscle Tissue Morphogenesis Response To Metal Ion Muscle Tissue Development Muscle Organ Morphogenesis Cardiac Ventricle Morphogenesis Regulation Of Muscle Filament Sliding Speed Myofibril Assembly Striated Muscle Contraction Skeletal Muscle Fiber Adaptation Detection Of Chemical Stimulus Involved In Sensory Perception Of Sour Taste Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Cardiac Ventricle Development Response To Inorganic Substance Actomyosin Structure Organization Muscle Structure Development Regulation Of Muscle Filament Sliding Diaphragm Contraction Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Cardiac Chamber Development Sensory Perception Of Sour Taste Involuntary Skeletal Muscle Contraction Striated Muscle Cell Development Skeletal Muscle Atrophy Muscle Cell Development Slow-twitch Skeletal Muscle Fiber Contraction Skeletal Muscle Thin Filament Assembly Striated Muscle Atrophy Cardiac Muscle Tissue Development Movement Of Cell Or Subcellular Component Cellular Response To Acidic PH Muscle Atrophy Atrial Cardiac Muscle Tissue Morphogenesis
Tagcloud ?		apposition axin2 bending bf bfr bones canonical compromised csa determinant epsilon histomorphometric hz ko littermate loaded loading mar mechanical mineral nfatc1 periosteal periosteum reductions tibia unloaded wnt wnt16 wt
Tagcloud (Difference) ?		apposition axin2 bending bf bfr bones canonical compromised csa determinant epsilon histomorphometric hz ko littermate loaded loading mar mechanical mineral nfatc1 periosteal periosteum reductions tibia unloaded wnt wnt16 wt
Tagcloud (Intersection) ?