TNNT2 and TNNC1

Number of citations of the paper that reports this interaction (PubMedID 9560191)
31

Data Source:
BioGRID (two hybrid)
HPRD (in vitro)

		TNNT2	TNNC1
Description		troponin T2, cardiac type	troponin C1, slow skeletal and cardiac type
Image
GO Annotations	Cellular Component	Cytosol Troponin Complex Striated Muscle Thin Filament Sarcomere Cardiac Myofibril Cardiac Troponin Complex	Cytosol Troponin Complex Sarcomere Contractile Muscle Fiber Cardiac Troponin Complex
	Molecular Function	Microfilament Motor Activity Actin Binding Protein Binding Tropomyosin Binding Troponin C Binding Troponin I Binding Identical Protein Binding	Calcium Ion Binding Protein Binding Cytoskeletal Protein Binding Troponin I Binding Troponin T Binding Protein Homodimerization Activity Metal Ion Binding Calcium-dependent Protein Binding Actin Filament Binding
	Biological Process	Regulation Of Muscle Contraction Striated Muscle Contraction Regulation Of Heart Contraction Muscle Filament Sliding Negative Regulation Of ATP-dependent Activity Positive Regulation Of ATP-dependent Activity Sarcomere Organization Response To Calcium Ion Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction	Diaphragm Contraction Skeletal Muscle Contraction Regulation Of Muscle Contraction Response To Metal Ion Transition Between Fast And Slow Fiber Muscle Filament Sliding Regulation Of Muscle Filament Sliding Speed Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction Cardiac Muscle Cell Contraction
Pathways		Striated Muscle Contraction	Striated Muscle Contraction
Drugs			Trifluoperazine Levosimendan Felodipine Bepridil Calcium Aluminium monostearate 5-[1-(3,4-Dimethoxy-Benzoyl)-1,2,3,4-Tetrahydro-Quinolin-6-Yl]-6-Methyl-3,6-Dihydro-[1,3,4]Thiadiazin-2-One N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide
Diseases		Dilated cardiomyopathy (DCM) Hypertrophic cardiomyopathy (HCM)
GWAS		Cardiac Troponin-T levels ( 23247143) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Height ( 28552196) Neurofibrillary tangles ( 25188341)	Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Feeling worry ( 29500382) Schizophrenia ( 23974872) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		16 interacting genes: APP KDM1A MAP3K5 MLX MORF4L1 MORF4L2 MST1 NOTCH3 PPP2R5A PRKCA TNNC1 TNNI1 TNNI3 TNNT1 TPM1 TRIM69	13 interacting genes: CDK1 MST1 POLR2G RBM15B TCP10L TNNI1 TNNI2 TNNI3 TNNT1 TNNT2 TRIM63 UBC UBE2C
Entrez ID		7139	7134
HPRD ID		01844	08930
Ensembl ID		ENSG00000118194	ENSG00000114854
Uniprot IDs		A0AAQ5BHX3 P45379 Q15607	P63316 Q6FH91
PDB IDs		1J1D 1J1E 4Y99 6KN7 6KN8 7UTI 7UTL 8FMM 8FMN 8FMO 8FMP 8FMQ 8FMR 8FMS 8FMT	1AP4 1IH0 1J1D 1J1E 1LXF 1MXL 1OZS 1SPY 1WRK 1WRL 2JT0 2JT3 2JT8 2JTZ 2JXL 2KDH 2KFX 2KGB 2KRD 2L1R 2L98 2MKP 2MLE 2MLF 2MZP 2N79 2N7L 3RV5 3SD6 3SWB 4GJE 4GJF 4GJG 4Y99 5VLN 5W88 5WCL 6KN7 6KN8 6MV3 7JGI 7SC2 7SC3 7SUP 7SVC 7SWG 7SWI 7SXC 7SXD 7UH9 7UHA 7UTI 7UTL 8FMM 8FMN 8FMO 8FMP 8FMQ 8FMR 8FMS 8FMT
Enriched GO Terms of Interacting Partners?		Troponin Complex Troponin T Binding Striated Muscle Contraction Skeletal Muscle Contraction Transition Between Fast And Slow Fiber Regulation Of Muscle System Process Cardiac Muscle Contraction Ventricular Cardiac Muscle Tissue Morphogenesis Regulation Of Skeletal Muscle Adaptation Cardiac Muscle Tissue Morphogenesis Regulation Of System Process Muscle Filament Sliding Regulation Of Muscle Contraction Actin-myosin Filament Sliding Muscle Tissue Morphogenesis Muscle Contraction Cardiac Troponin Complex Muscle System Process Actin-mediated Cell Contraction Regulation Of Smooth Muscle Cell Proliferation Sarcomere Actin Filament-based Movement Regulation Of Double-strand Break Repair Via Homologous Recombination Contractile Muscle Fiber Positive Regulation Of Smooth Muscle Cell Proliferation Anatomical Structure Morphogenesis System Process Regulation Of DNA Recombination NuA4 Histone Acetyltransferase Complex Regulation Of Double-strand Break Repair Protein Homodimerization Activity Neuron Maturation Positive Regulation Of RNA Biosynthetic Process Enzyme Binding Cytosol Positive Regulation Of DNA-templated Transcription Response To Reactive Oxygen Species Tissue Morphogenesis Actin Filament-based Process Sarcomere Organization Amyloid-beta Complex Growth Cone Lamellipodium Chromatin Organization Regulation Of Response To Calcium Ion Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Amylin Binding Positive Regulation Of RNA Metabolic Process Positive Regulation Of Toll Signaling Pathway Regulation Of Muscle Filament Sliding Speed Actin Filament Binding	Troponin Complex Troponin T Binding Striated Muscle Contraction Muscle Contraction Skeletal Muscle Contraction Muscle System Process Cardiac Muscle Contraction Regulation Of Muscle System Process Cardiac Troponin Complex Troponin C Binding Ventricular Cardiac Muscle Tissue Morphogenesis Regulation Of Muscle Contraction Cardiac Muscle Tissue Morphogenesis Transition Between Fast And Slow Fiber Cardiac Myofibril Muscle Tissue Morphogenesis Regulation Of Skeletal Muscle Adaptation Negative Regulation Of ATP-dependent Activity Contractile Muscle Fiber Tropomyosin Binding Regulation Of System Process Muscle Filament Sliding Actin-myosin Filament Sliding Actin Binding Regulation Of ATP-dependent Activity Actin-mediated Cell Contraction Sarcomere Organization System Process Pronuclear Fusion Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Slow-twitch Skeletal Muscle Fiber Contraction Sarcomere Actin Filament-based Movement Mitotic DNA-templated DNA Replication Cyclin B1-CDK1 Complex Cyclin A1-CDK1 Complex Cyclin A2-CDK1 Complex Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Spermatocyte Division Protein Polymerization Mitotic DNA Replication DNA Synthesis Involved In Mitotic DNA Replication Cyclin-dependent Protein Kinase Activity Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Schwann Cell Differentiation Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Regulation Of Striated Muscle Contraction Troponin I Binding Positive Regulation Of Exit From Mitosis LncRNA Transcription
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