TNNT2 and TNNC1

Number of citations of the paper that reports this interaction (PMID 12840750)
160

Data Source:
BioGRID (two hybrid)
HPRD (in vitro)

		TNNT2	TNNC1
Gene Name		troponin T type 2 (cardiac)	troponin C type 1 (slow)
Image
Gene Ontology Annotations	Cellular Component	Cytosol Troponin Complex Striated Muscle Thin Filament Sarcomere	Nucleoplasm Mitochondrion Cytosol Troponin Complex Actin Cytoskeleton
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Tropomyosin Binding ATPase Activity Troponin C Binding Troponin I Binding	Calcium Ion Binding Protein Binding Troponin I Binding Troponin T Binding Protein Homodimerization Activity Calcium-dependent Protein Binding Actin Filament Binding
	Biological Process	Regulation Of Muscle Contraction Regulation Of Heart Contraction Metabolic Process Muscle Filament Sliding Negative Regulation Of ATPase Activity Positive Regulation Of ATPase Activity Sarcomere Organization Response To Calcium Ion Atrial Cardiac Muscle Tissue Morphogenesis Ventricular Cardiac Muscle Tissue Morphogenesis	Diaphragm Contraction Regulation Of Muscle Contraction Response To Metal Ion Muscle Filament Sliding Regulation Of Muscle Filament Sliding Speed Regulation Of ATPase Activity Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction
Pathways		Striated Muscle Contraction	Striated Muscle Contraction
Drugs			Trifluoperazine Levosimendan Felodipine Bepridil Calcium Dihydroxyaluminium 5-[1-(3,4-Dimethoxy-Benzoyl)-1,2,3,4-Tetrahydro-Quinolin-6-Yl]-6-Methyl-3,6-Dihydro-[1,3,4]Thiadiazin-2-One N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide
Diseases
GWAS		Cardiac Troponin-T levels ( 23247143)	Bipolar disorder ( 21926972)
Protein-Protein Interactions		10 interactors: APP KDM1A MAP3K5 MORF4L2 NOTCH3 PRKCA TNNC1 TNNI1 TNNI3 TPM1	11 interactors: CDK1 POLR2G RBM15B TCP10L TNNI1 TNNI2 TNNI3 TNNT1 TNNT2 TRIM63 UBE2C
Entrez ID		7139	7134
HPRD ID		01844	08930
Ensembl ID		ENSG00000118194	ENSG00000114854
Uniprot IDs		P45379 Q15607	P63316 Q6FH91
PDB IDs		1J1D 1J1E	1AP4 1IH0 1J1D 1J1E 1LXF 1MXL 1OZS 1SPY 1WRK 1WRL 2JT0 2JT3 2JT8 2JTZ 2JXL 2KDH 2KFX 2KGB 2KRD 2L1R 2L98 3RV5 3SD6 3SWB 4GJE 4GJF 4GJG
Enriched GO Terms of Interacting Partners?		Actin-myosin Filament Sliding Muscle Filament Sliding Ventricular Cardiac Muscle Tissue Morphogenesis Actin-mediated Cell Contraction Regulation Of Muscle Contraction Ventricular Cardiac Muscle Tissue Development Cardiac Muscle Tissue Morphogenesis Muscle Tissue Morphogenesis Actin Filament-based Movement Muscle Organ Morphogenesis Cardiac Ventricle Morphogenesis Cardiac Ventricle Development Cardiac Chamber Development Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Cardiovascular System Development Regulation Of ATPase Activity Cardiac Muscle Tissue Development Muscle Structure Development Cardiac Muscle Contraction Muscle Contraction Heart Morphogenesis Heart Contraction Organ Development Muscle System Process Muscle Organ Development Cellular Calcium Ion Homeostasis Striated Muscle Contraction Calcium Ion Homeostasis Striated Muscle Tissue Development Negative Regulation Of ATPase Activity Muscle Tissue Development Regulation Of Systemic Arterial Blood Pressure Movement Of Cell Or Subcellular Component Anatomical Structure Morphogenesis Cellular Metal Ion Homeostasis Blood Vessel Morphogenesis Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis System Development Neurological System Process Involved In Regulation Of Systemic Arterial Blood Pressure Heart Development Blood Vessel Development Cellular Chemical Homeostasis Regulation Of Blood Pressure Vasculature Development Ion Homeostasis Wound Healing Multicellular Organismal Development Anatomical Structure Development	Actin-myosin Filament Sliding Muscle Filament Sliding Actin-mediated Cell Contraction Actin Filament-based Movement Muscle Contraction Muscle System Process Regulation Of Muscle Contraction Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Tissue Development Ventricular Cardiac Muscle Tissue Development Cardiac Muscle Tissue Morphogenesis Muscle Tissue Morphogenesis Muscle Organ Morphogenesis Cardiac Ventricle Morphogenesis Negative Regulation Of ATPase Activity Actin Filament-based Process Striated Muscle Contraction Striated Muscle Tissue Development Muscle Tissue Development Cardiac Ventricle Development Movement Of Cell Or Subcellular Component Cardiac Chamber Development Muscle Structure Development Heart Development Skeletal Muscle Contraction Heart Morphogenesis Regulation Of ATPase Activity Musculoskeletal Movement Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Muscle Organ Development Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Cellular Macromolecule Catabolic Process Cardiovascular System Development Pronuclear Fusion Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of MRNA Processing Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Metabolic Process Free Ubiquitin Chain Polymerization Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Positive Regulation Of Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination
Tagcloud ?		apposition axin2 bending bf bfr bones canonical compromised csa determinant epsilon histomorphometric hz ko littermate loaded loading mar mechanical mineral nfatc1 periosteal periosteum reductions tibia unloaded wnt wnt16 wt
Tagcloud (Difference) ?		apposition axin2 bending bf bfr bones canonical compromised csa determinant epsilon histomorphometric hz ko littermate loaded loading mar mechanical mineral nfatc1 periosteal periosteum reductions tibia unloaded wnt wnt16 wt
Tagcloud (Intersection) ?