TNF and ADAM17

Number of citations of the paper that reports this interaction (PMID 10799478)
24

Data Source:
HPRD (in vitro, in vivo)

		TNF	ADAM17
Gene Name		tumor necrosis factor	ADAM metallopeptidase domain 17
Image
Gene Ontology Annotations	Cellular Component	Phagocytic Cup Extracellular Region Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Raft Recycling Endosome	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Focal Adhesion Cell Surface Actin Cytoskeleton Membrane Apical Plasma Membrane Ruffle Membrane Membrane Raft
	Molecular Function	Protease Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Identical Protein Binding Transcription Regulatory Region DNA Binding	Metalloendopeptidase Activity Notch Binding Interleukin-6 Receptor Binding Integrin Binding Protein Binding Metallopeptidase Activity Zinc Ion Binding SH3 Domain Binding PDZ Domain Binding
	Biological Process	Protein Import Into Nucleus, Translocation Negative Regulation Of Transcription From RNA Polymerase II Promoter MAPK Cascade Activation Of MAPKKK Activity Activation Of MAPK Activity Response To Hypoxia Cell Activation Positive Regulation Of Cytokine Production Positive Regulation Of Protein Phosphorylation Negative Regulation Of L-glutamate Transport Chronic Inflammatory Response To Antigenic Stimulus Negative Regulation Of Cytokine Secretion Involved In Immune Response Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Skeletal Muscle Contraction Glucose Metabolic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Transformed Cell Apoptotic Process Inflammatory Response Humoral Immune Response JNK Cascade Negative Regulation Of Cell Proliferation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Radiation Response To Virus Response To Salt Stress Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Alkaline Phosphatase Activity Negative Regulation Of Lipid Storage Response To Activity Calcium-mediated Signaling Extracellular Matrix Organization Osteoclast Differentiation Sequestering Of Triglyceride Positive Regulation Of Protein Complex Assembly Positive Regulation Of Fever Generation Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Interleukin-6 Production Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-18 Production Positive Regulation Of Interleukin-6 Production Receptor Biosynthetic Process Positive Regulation Of Peptidyl-serine Phosphorylation Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Heterotypic Cell-cell Adhesion Positive Regulation Of NF-kappaB Import Into Nucleus Response To Drug Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Protein Complex Disassembly Positive Regulation Of Protein Complex Disassembly Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of MAP Kinase Activity Protein Kinase B Signaling Positive Regulation Of JUN Kinase Activity Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Growth Of Symbiont In Host Negative Regulation Of Viral Genome Replication Positive Regulation Of Chemokine Biosynthetic Process Positive Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Myoblast Differentiation Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Action Potential Positive Regulation Of Mitotic Nuclear Division Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Translational Initiation By Iron Negative Regulation Of Glucose Import Embryonic Digestive Tract Development Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Cytokine Secretion Positive Regulation Of Phagocytosis Regulation Of Insulin Secretion Positive Regulation Of Synaptic Transmission Defense Response To Gram-positive Bacterium Leukocyte Tethering Or Rolling Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Negative Regulation Of Lipid Catabolic Process Regulation Of Immunoglobulin Secretion Positive Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Transport Response To Glucocorticoid Positive Regulation Of NFAT Protein Import Into Nucleus Positive Regulation Of Hair Follicle Development Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Vitamin D Biosynthetic Process Positive Regulation Of Calcidiol 1-monooxygenase Activity Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Regulation Of Branching Involved In Salivary Gland Morphogenesis Negative Regulation Of Branching Involved In Lung Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Amino Acid Stimulus Cellular Response To Nicotine Cellular Response To Organic Cyclic Compound Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Podosome Assembly Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Necroptotic Signaling Pathway Response To Gold Nanoparticle Positive Regulation Of Protein Localization To Cell Surface Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Response To Hypoxia Positive Regulation Of Protein Phosphorylation Neutrophil Mediated Immunity Germinal Center Formation Positive Regulation Of Leukocyte Chemotaxis Proteolysis Membrane Protein Ectodomain Proteolysis Cell Adhesion Epidermal Growth Factor Receptor Signaling Pathway Notch Signaling Pathway Notch Receptor Processing Positive Regulation Of Cell Proliferation Positive Regulation Of T Cell Chemotaxis Extracellular Matrix Disassembly B Cell Differentiation Extracellular Matrix Organization Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Collagen Catabolic Process Membrane Protein Intracellular Domain Proteolysis Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Response To Lipopolysaccharide Negative Regulation Of Interleukin-8 Production Positive Regulation Of Chemokine Production Regulation Of Mast Cell Apoptotic Process T Cell Differentiation In Thymus Cell Adhesion Mediated By Integrin Wound Healing, Spreading Of Epidermal Cells Epidermal Growth Factor-activated Receptor Transactivation By G-protein Coupled Receptor Signaling Pathway Response To Drug Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Neurotrophin TRK Receptor Signaling Pathway Spleen Development Cell Motility PMA-inducible Membrane Protein Ectodomain Proteolysis Positive Regulation Of Cellular Component Movement Response To High Density Lipoprotein Particle JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Apoptotic Signaling Pathway
Pathways		TNF signaling Death Receptor Signalling Transcriptional regulation of white adipocyte differentiation Programmed Cell Death Extrinsic Pathway	Signaling by NOTCH1 HD Domain Mutants in Cancer Constitutive Signaling by NOTCH1 HD Domain Mutants Hedgehog ligand biogenesis TNF signaling Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Death Receptor Signalling Signaling by EGFRvIII in Cancer Degradation of the extracellular matrix Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Release of Hh-Np from the secreting cell Signaling by NOTCH1 Programmed Cell Death Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer Regulated proteolysis of p75NTR Signalling by NGF Collagen degradation Signaling by NOTCH Processing-defective Hh variants abrogate ligand secretion Signaling by Ligand-Responsive EGFR Variants in Cancer Cytokine Signaling in Immune system p75 NTR receptor-mediated signalling Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by ERBB4 Signaling by EGFR Activated NOTCH1 Transmits Signal to the Nucleus Nuclear signaling by ERBB4 Signaling by EGFR in Cancer Signaling by Hedgehog Signaling by NOTCH1 PEST Domain Mutants in Cancer Constitutive Signaling by NOTCH1 PEST Domain Mutants Extrinsic Pathway Growth hormone receptor signaling
Drugs		Etanercept Adalimumab Infliximab Chloroquine Thalidomide Glucosamine Clenbuterol Pranlukast Amrinone golimumab Certolizumab pegol Pomalidomide
Diseases
GWAS		AIDS progression ( 19115949) Crohn's disease ( 21102463) Neonatal lupus ( 20662065)
Protein-Protein Interactions		21 interactors: ADAM17 ADAM9 BGN CSF1 DCN FYN IFNG LYN MMP17 NFKBIA PDIK1L POU2F1 PRTN3 RC3H1 RIPK1 TNFAIP3 TNFRSF1A TNFRSF1B TRADD TRAF2 YWHAQ	14 interactors: DLG1 ERBB4 FHL2 MAD2L1 MAD2L2 NOTCH1 PTPN3 SH3D19 TGFA TIMP3 TNF TNFRSF1A TNFRSF1B TNFSF11
Entrez ID		7124	6868
HPRD ID		01855	04703
Ensembl ID		ENSG00000232810	ENSG00000151694
Uniprot IDs		P01375 Q5STB3	B2RNB2 P78536
PDB IDs		1A8M 1TNF 2AZ5 2E7A 2TUN 2ZJC 2ZPX 3ALQ 3IT8 3L9J 3WD5 4G3Y 4TSV 5TSW	1BKC 1ZXC 2A8H 2DDF 2FV5 2FV9 2I47 2M2F 2OI0 3B92 3CKI 3E8R 3EDZ 3EWJ 3G42 3KMC 3KME 3L0T 3L0V 3LE9 3LEA 3LGP 3O64
Enriched GO Terms of Interacting Partners?		Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Positive Regulation Of Cellular Protein Metabolic Process Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Response To Bacterium Positive Regulation Of Intracellular Signal Transduction Response To Tumor Necrosis Factor Immune Response Immune System Process Apoptotic Process Regulation Of Protein Metabolic Process Cellular Response To Lipopolysaccharide Regulation Of Intracellular Signal Transduction Response To Other Organism Programmed Cell Death Regulation Of Signal Transduction Cellular Response To Molecule Of Bacterial Origin Response To Biotic Stimulus Cell Death Death Cellular Response To Organic Substance Regulation Of Apoptotic Process Regulation Of Cytokine Production Apoptotic Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Death Response To Lipid Regulation Of Signaling Response To Organic Substance Cellular Response To Tumor Necrosis Factor Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Immune System Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Extrinsic Apoptotic Signaling Pathway Regulation Of Immune System Process Cellular Response To Lipid Defense Response Positive Regulation Of Metabolic Process Response To Stress Positive Regulation Of Protein Phosphorylation Leukocyte Activation Regulation Of Protein Phosphorylation Positive Regulation Of Proteolysis Regulation Of Protein Localization Positive Regulation Of Membrane Protein Ectodomain Proteolysis Innate Immune Response Leukocyte Differentiation Positive Regulation Of Phosphorylation	Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Cellular Protein Metabolic Process Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Proteolysis Positive Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of Protein Phosphorylation Regulation Of Mitotic Cell Cycle Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Gland Development Positive Regulation Of Phosphorylation Cellular Response To Tumor Necrosis Factor Positive Regulation Of Protein Modification Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Negative Regulation Of Protein Catabolic Process Regulation Of Mitotic Nuclear Division Response To Tumor Necrosis Factor Regulation Of Protein Phosphorylation Regulation Of Catalytic Activity Negative Regulation Of APC-Cdc20 Complex Activity Cell Proliferation Regulation Of Cellular Amino Acid Metabolic Process Mammary Gland Lobule Development Mammary Gland Alveolus Development Regulation Of Phosphorylation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of Kinase Activity Positive Regulation Of JAK-STAT Cascade Regulation Of Cellular Ketone Metabolic Process Negative Regulation Of Mitotic Cell Cycle Regulation Of Apoptotic Process Regulation Of Cell Cycle Regulation Of Phosphorus Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Cell Death Positive Regulation Of Transferase Activity Regulation Of Cell Division Positive Regulation Of Cellular Biosynthetic Process Regulation Of Cellular Localization Positive Regulation Of Fever Generation Activation Of Protein Kinase Activity
Tagcloud ?		aminopurine ap catalytically cooperate cotreatment de elicit endothelial exert gamma ifn ikappabbeta inactive inducible involves kappab neuronal normally novo pkr possibility potentiate require stranded synergistic synergistically translocation ultimately	anchored apma arguing betacellulin bzatp cd23 cd62 chimeras constitutive convertase cytoplasmic disintegrin dispensable domain ectodomain influences influx ionomycin metalloprotease metalloproteinase motif negatively pro retention shedding tgfalpha translationally transmembrane
Tagcloud (Difference) ?		aminopurine ap catalytically cooperate cotreatment de elicit endothelial exert gamma ifn ikappabbeta inactive inducible involves kappab neuronal normally novo pkr possibility potentiate require stranded synergistic synergistically translocation ultimately	anchored apma arguing betacellulin bzatp cd23 cd62 chimeras constitutive convertase cytoplasmic disintegrin dispensable domain ectodomain influences influx ionomycin metalloprotease metalloproteinase motif negatively pro retention shedding tgfalpha translationally transmembrane
Tagcloud (Intersection) ?