TNF and RIPK1

Number of citations of the paper that reports this interaction (PMID 16603398)
208

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)

		TNF	RIPK1
Gene Name		tumor necrosis factor	receptor (TNFRSF)-interacting serine-threonine kinase 1
Image
Gene Ontology Annotations	Cellular Component	Phagocytic Cup Extracellular Region Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Raft Recycling Endosome	Cytoplasm Mitochondrion Cytosol Death-inducing Signaling Complex Receptor Complex Membrane Raft Ripoptosome
	Molecular Function	Protease Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Identical Protein Binding Transcription Regulatory Region DNA Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Death Receptor Binding Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Protein Complex Binding Identical Protein Binding Death Domain Binding
	Biological Process	Protein Import Into Nucleus, Translocation Negative Regulation Of Transcription From RNA Polymerase II Promoter MAPK Cascade Activation Of MAPKKK Activity Activation Of MAPK Activity Response To Hypoxia Cell Activation Positive Regulation Of Cytokine Production Positive Regulation Of Protein Phosphorylation Negative Regulation Of L-glutamate Transport Chronic Inflammatory Response To Antigenic Stimulus Negative Regulation Of Cytokine Secretion Involved In Immune Response Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Skeletal Muscle Contraction Glucose Metabolic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Transformed Cell Apoptotic Process Inflammatory Response Humoral Immune Response JNK Cascade Negative Regulation Of Cell Proliferation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Radiation Response To Virus Response To Salt Stress Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Alkaline Phosphatase Activity Negative Regulation Of Lipid Storage Response To Activity Calcium-mediated Signaling Extracellular Matrix Organization Osteoclast Differentiation Sequestering Of Triglyceride Positive Regulation Of Protein Complex Assembly Positive Regulation Of Fever Generation Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Interleukin-6 Production Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-18 Production Positive Regulation Of Interleukin-6 Production Receptor Biosynthetic Process Positive Regulation Of Peptidyl-serine Phosphorylation Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Heterotypic Cell-cell Adhesion Positive Regulation Of NF-kappaB Import Into Nucleus Response To Drug Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Protein Complex Disassembly Positive Regulation Of Protein Complex Disassembly Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of MAP Kinase Activity Protein Kinase B Signaling Positive Regulation Of JUN Kinase Activity Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Growth Of Symbiont In Host Negative Regulation Of Viral Genome Replication Positive Regulation Of Chemokine Biosynthetic Process Positive Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Myoblast Differentiation Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Action Potential Positive Regulation Of Mitotic Nuclear Division Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Translational Initiation By Iron Negative Regulation Of Glucose Import Embryonic Digestive Tract Development Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Cytokine Secretion Positive Regulation Of Phagocytosis Regulation Of Insulin Secretion Positive Regulation Of Synaptic Transmission Defense Response To Gram-positive Bacterium Leukocyte Tethering Or Rolling Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Negative Regulation Of Lipid Catabolic Process Regulation Of Immunoglobulin Secretion Positive Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Transport Response To Glucocorticoid Positive Regulation Of NFAT Protein Import Into Nucleus Positive Regulation Of Hair Follicle Development Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Vitamin D Biosynthetic Process Positive Regulation Of Calcidiol 1-monooxygenase Activity Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Regulation Of Branching Involved In Salivary Gland Morphogenesis Negative Regulation Of Branching Involved In Lung Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Amino Acid Stimulus Cellular Response To Nicotine Cellular Response To Organic Cyclic Compound Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Podosome Assembly Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Necroptotic Signaling Pathway Response To Gold Nanoparticle Positive Regulation Of Protein Localization To Cell Surface Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Positive Regulation Of Protein Phosphorylation Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of JUN Kinase Activity Positive Regulation Of Type I Interferon Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Tumor Necrosis Factor-mediated Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Response To Tumor Necrosis Factor TRIF-dependent Toll-like Receptor Signaling Pathway Peptidyl-serine Autophosphorylation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Protein Catabolic Process Innate Immune Response Positive Regulation Of Macrophage Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of JNK Cascade Protein Autophosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homooligomerization Protein Heterooligomerization Positive Regulation Of Necroptotic Process T Cell Apoptotic Process Necroptotic Process Regulation Of ATP:ADP Antiporter Activity Cellular Response To Tumor Necrosis Factor Cellular Response To Growth Factor Stimulus Extrinsic Apoptotic Signaling Pathway Ripoptosome Assembly Necroptotic Signaling Pathway Ripoptosome Assembly Involved In Necroptotic Process Amyloid Fibril Formation Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		TNF signaling Death Receptor Signalling Transcriptional regulation of white adipocyte differentiation Programmed Cell Death Extrinsic Pathway	Regulation by c-FLIP Caspase-8 activation by cleavage Dimerization of procaspase-8 IKK complex recruitment mediated by RIP1 TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA MyD88-independent cascade RIP-mediated NFkB activation via ZBP1 Activated TLR4 signalling RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades ZBP1(DAI) mediated induction of type I IFNs Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Programmed Cell Death NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 TRIF-mediated programmed cell death Innate Immune System
Drugs		Etanercept Adalimumab Infliximab Chloroquine Thalidomide Glucosamine Clenbuterol Pranlukast Amrinone golimumab Certolizumab pegol Pomalidomide
Diseases
GWAS		AIDS progression ( 19115949) Crohn's disease ( 21102463) Neonatal lupus ( 20662065)
Protein-Protein Interactions		21 interactors: ADAM17 ADAM9 BGN CSF1 DCN FYN IFNG LYN MMP17 NFKBIA PDIK1L POU2F1 PRTN3 RC3H1 RIPK1 TNFAIP3 TNFRSF1A TNFRSF1B TRADD TRAF2 YWHAQ	45 interactors: BIRC2 BIRC3 CASP8 CCDC50 CDC42BPB CFLAR CRADD EGFR FADD FAS HSP90AA1 IKBKB IKBKG ITCH MAP3K14 MAP3K3 MAP3K8 NFKB1 NUMBL OTUD1 PELI1 PTK2 RIPK3 RNF11 RNF216 SQSTM1 TAX1BP1 TICAM1 TNF TNFAIP3 TNFRSF10A TNFRSF10B TNFRSF1A TRADD TRAF1 TRAF2 TRAF3 TRAF5 TRIM38 TRPC4AP UBE2N USP2 XIAP YOD1 ZFAND5
Entrez ID		7124	8737
HPRD ID		01855	04583
Ensembl ID		ENSG00000232810	ENSG00000137275
Uniprot IDs		P01375 Q5STB3	Q13546
PDB IDs		1A8M 1TNF 2AZ5 2E7A 2TUN 2ZJC 2ZPX 3ALQ 3IT8 3L9J 3WD5 4G3Y 4TSV 5TSW	4ITH 4ITI 4ITJ
Enriched GO Terms of Interacting Partners?		Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Positive Regulation Of Cellular Protein Metabolic Process Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Response To Bacterium Positive Regulation Of Intracellular Signal Transduction Response To Tumor Necrosis Factor Immune Response Immune System Process Apoptotic Process Regulation Of Protein Metabolic Process Cellular Response To Lipopolysaccharide Regulation Of Intracellular Signal Transduction Response To Other Organism Programmed Cell Death Regulation Of Signal Transduction Cellular Response To Molecule Of Bacterial Origin Response To Biotic Stimulus Cell Death Death Cellular Response To Organic Substance Regulation Of Apoptotic Process Regulation Of Cytokine Production Apoptotic Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Death Response To Lipid Regulation Of Signaling Response To Organic Substance Cellular Response To Tumor Necrosis Factor Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Immune System Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Extrinsic Apoptotic Signaling Pathway Regulation Of Immune System Process Cellular Response To Lipid Defense Response Positive Regulation Of Metabolic Process Response To Stress Positive Regulation Of Protein Phosphorylation Leukocyte Activation Regulation Of Protein Phosphorylation Positive Regulation Of Proteolysis Regulation Of Protein Localization Positive Regulation Of Membrane Protein Ectodomain Proteolysis Innate Immune Response Leukocyte Differentiation Positive Regulation Of Phosphorylation	Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apoptotic Process Programmed Cell Death Cell Death Death Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Toll-like Receptor 4 Signaling Pathway Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Innate Immune Response Regulation Of Innate Immune Response Regulation Of Signal Transduction Toll-like Receptor Signaling Pathway Regulation Of Immune System Process Positive Regulation Of NF-kappaB Transcription Factor Activity Immune Response-regulating Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Signaling MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Protein Metabolic Process Innate Immune Response Positive Regulation Of Cellular Metabolic Process Signal Transduction Immune Response NIK/NF-kappaB Signaling Regulation Of Immune Response Positive Regulation Of Immune System Process Positive Regulation Of Immune Response Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signaling Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Type I Interferon Production Cellular Response To Mechanical Stimulus Cell Communication Defense Response Positive Regulation Of Protein Modification Process
Tagcloud ?		aminopurine ap catalytically cooperate cotreatment de elicit endothelial exert gamma ifn ikappabbeta inactive inducible involves kappab neuronal normally novo pkr possibility potentiate require stranded synergistic synergistically translocation ultimately	allowed autocrine back deficient endoplasmic er instead interacting intrinsic kills l929 lineage lymphotoxin mlkl necroptosis necrosis opportunities pathologies protect remarkably repression rescue reticulum ripk3 stress stressors switch tnfr1 unresolved
Tagcloud (Difference) ?		aminopurine ap catalytically cooperate cotreatment de elicit endothelial exert gamma ifn ikappabbeta inactive inducible involves kappab neuronal normally novo pkr possibility potentiate require stranded synergistic synergistically translocation ultimately	allowed autocrine back deficient endoplasmic er instead interacting intrinsic kills l929 lineage lymphotoxin mlkl necroptosis necrosis opportunities pathologies protect remarkably repression rescue reticulum ripk3 stress stressors switch tnfr1 unresolved
Tagcloud (Intersection) ?