TNF and FYN

Number of citations of the paper that reports this interaction (PMID 9230816)
1

Data Source:
BioGRID (pull down)

		TNF	FYN
Gene Name		tumor necrosis factor	FYN proto-oncogene, Src family tyrosine kinase
Image
Gene Ontology Annotations	Cellular Component	Phagocytic Cup Extracellular Region Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Raft Recycling Endosome	Nucleus Mitochondrion Endosome Cytosol Actin Filament Plasma Membrane Postsynaptic Density Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Membrane Raft
	Molecular Function	Protease Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Identical Protein Binding Transcription Regulatory Region DNA Binding	G-protein Coupled Receptor Binding Glycoprotein Binding Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Tubulin Binding T Cell Receptor Binding CD4 Receptor Binding CD8 Receptor Binding Phosphatidylinositol 3-kinase Binding Ion Channel Binding Metal Ion Binding Ephrin Receptor Binding Peptide Hormone Receptor Binding Growth Factor Receptor Binding
	Biological Process	Protein Import Into Nucleus, Translocation Negative Regulation Of Transcription From RNA Polymerase II Promoter MAPK Cascade Activation Of MAPKKK Activity Activation Of MAPK Activity Response To Hypoxia Cell Activation Positive Regulation Of Cytokine Production Positive Regulation Of Protein Phosphorylation Negative Regulation Of L-glutamate Transport Chronic Inflammatory Response To Antigenic Stimulus Negative Regulation Of Cytokine Secretion Involved In Immune Response Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Skeletal Muscle Contraction Glucose Metabolic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Transformed Cell Apoptotic Process Inflammatory Response Humoral Immune Response JNK Cascade Negative Regulation Of Cell Proliferation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Radiation Response To Virus Response To Salt Stress Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Alkaline Phosphatase Activity Negative Regulation Of Lipid Storage Response To Activity Calcium-mediated Signaling Extracellular Matrix Organization Osteoclast Differentiation Sequestering Of Triglyceride Positive Regulation Of Protein Complex Assembly Positive Regulation Of Fever Generation Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Interleukin-6 Production Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-18 Production Positive Regulation Of Interleukin-6 Production Receptor Biosynthetic Process Positive Regulation Of Peptidyl-serine Phosphorylation Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Heterotypic Cell-cell Adhesion Positive Regulation Of NF-kappaB Import Into Nucleus Response To Drug Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Protein Complex Disassembly Positive Regulation Of Protein Complex Disassembly Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of MAP Kinase Activity Protein Kinase B Signaling Positive Regulation Of JUN Kinase Activity Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Growth Of Symbiont In Host Negative Regulation Of Viral Genome Replication Positive Regulation Of Chemokine Biosynthetic Process Positive Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Myoblast Differentiation Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Action Potential Positive Regulation Of Mitotic Nuclear Division Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Translational Initiation By Iron Negative Regulation Of Glucose Import Embryonic Digestive Tract Development Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Cytokine Secretion Positive Regulation Of Phagocytosis Regulation Of Insulin Secretion Positive Regulation Of Synaptic Transmission Defense Response To Gram-positive Bacterium Leukocyte Tethering Or Rolling Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Negative Regulation Of Lipid Catabolic Process Regulation Of Immunoglobulin Secretion Positive Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Transport Response To Glucocorticoid Positive Regulation Of NFAT Protein Import Into Nucleus Positive Regulation Of Hair Follicle Development Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Vitamin D Biosynthetic Process Positive Regulation Of Calcidiol 1-monooxygenase Activity Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Regulation Of Branching Involved In Salivary Gland Morphogenesis Negative Regulation Of Branching Involved In Lung Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Amino Acid Stimulus Cellular Response To Nicotine Cellular Response To Organic Cyclic Compound Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Podosome Assembly Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Necroptotic Signaling Pathway Response To Gold Nanoparticle Positive Regulation Of Protein Localization To Cell Surface Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Neuron Migration Protein Phosphorylation Calcium Ion Transport Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Axon Guidance Central Nervous System Development Blood Coagulation Learning Feeding Behavior Regulation Of Cell Shape Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process Cell Migration Cell Differentiation Platelet Activation Forebrain Development T Cell Costimulation Intracellular Signal Transduction Cellular Response To Platelet-derived Growth Factor Stimulus Peptidyl-tyrosine Autophosphorylation Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis T Cell Activation Regulation Of Cell Proliferation Negative Regulation Of Protein Catabolic Process Response To Drug Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Neuron Apoptotic Process Innate Immune Response Response To Ethanol Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Dendrite Morphogenesis Regulation Of Defense Response To Virus By Virus Activated T Cell Proliferation T Cell Receptor Signaling Pathway Leukocyte Migration Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		TNF signaling Death Receptor Signalling Transcriptional regulation of white adipocyte differentiation Programmed Cell Death Extrinsic Pathway	Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease DCC mediated attractive signaling Netrin mediated repulsion signals Signaling by EGFRvIII in Cancer Nef and signal transduction Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) Regulation of KIT signaling PI3K/AKT activation PI-3K cascade EPH-Ephrin signaling Fcgamma receptor (FCGR) dependent phagocytosis FCGR activation Signaling by PDGF DAP12 interactions GAB1 signalosome Host Interactions of HIV factors CD28 co-stimulation CD28 dependent PI3K/Akt signaling The role of Nef in HIV-1 replication and disease pathogenesis Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins Signaling by VEGF Downstream signal transduction Sema3A PAK dependent Axon repulsion Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Nephrin interactions SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling PI3K/AKT Signaling in Cancer Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling Adaptive Immune System Platelet Adhesion to exposed collagen Axon guidance Costimulation by the CD28 family PIP3 activates AKT signaling HIV Infection VEGFA-VEGFR2 Pathway EPHB-mediated forward signaling EPHA-mediated growth cone collapse Ephrin signaling EPH-ephrin mediated repulsion of cells PI3K events in ERBB2 signaling Regulation of signaling by CBL Downstream signaling of activated FGFR NCAM signaling for neurite out-growth Netrin-1 signaling Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Innate Immune System Signalling by NGF Semaphorin interactions CTLA4 inhibitory signaling Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer PECAM1 interactions CD28 dependent Vav1 pathway Signaling by FGFR Cell surface interactions at the vascular wall GPVI-mediated activation cascade
Drugs		Etanercept Adalimumab Infliximab Chloroquine Thalidomide Glucosamine Clenbuterol Pranlukast Amrinone golimumab Certolizumab pegol Pomalidomide	Dasatinib 1-Methoxy-2-[2-(2-Methoxy-Ethoxy]-Ethane
Diseases
GWAS		AIDS progression ( 19115949) Crohn's disease ( 21102463) Neonatal lupus ( 20662065)	Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		21 interactors: ADAM17 ADAM9 BGN CSF1 DCN FYN IFNG LYN MMP17 NFKBIA PDIK1L POU2F1 PRTN3 RC3H1 RIPK1 TNFAIP3 TNFRSF1A TNFRSF1B TRADD TRAF2 YWHAQ	182 interactors: ACP1 ADAM15 ADD2 ARHGAP32 ARHGAP33 ATXN1 BCAR1 BCL3 BTK C7orf25 C8orf33 CASP3 CASP8 CAV1 CBL CBLB CBLC CD19 CD2 CD226 CD247 CD2AP CD36 CD44 CD48 CD5 CD55 CD79A CD79B CDH1 CDK1 CDK5 CLTC CMA1 CNN1 CNN3 CNTN1 CNTNAP1 CRK CSF1R CSF2RB CSK CTLA4 CTNNB1 CTNND2 DAG1 DLG4 DOK1 DOK3 DOK4 EFS ENO1 EPHA3 EPHA4 EPHA8 EPHB3 EVL FAS FASLG FCER2 FCGR2A FLOT1 FLOT2 FLT1 FNBP4 FYB GAB3 GNB2L1 GP6 GRAP GRB10 GRB2 GRIN1 GRIN2A GRIN2B HNRNPK HRAS HSP90AA1 HTR6 IL1B IL2RB IL7R IRS1 ITCH ITGB4 ITK ITPR1 JAK2 JUP KDM1A KDR KHDRBS1 KIT LAT LCP2 MAG MAP2 MAPT MCAM MED28 MS4A1 NCAM1 NEDD4 NEDD9 NMT1 NPHS1 NR3C1 NTRK2 PAG1 PAK2 PDE4D PDGFRB PECAM1 PIK3R1 PIK3R2 PLAUR PLCG1 PLCG2 PLD2 PRKCD PRKCE PRKCH PRKCQ PRKCZ PRMT6 PTK2 PTK2B PTPN11 PTPN5 PTPRA PTPRC PTPRE PTPRF PTPRZ1 PXN RAF1 RPL10 SDC3 SH2B2 SH2D1A SH3BP2 SHC1 SIT1 SKAP1 SKAP2 SLAMF1 SNCA SOCS1 SOS1 SPHK1 SPHK2 SPN STAT1 STAT3 SUV39H1 SYK TCAP THY1 TNF TNK2 TNNT1 TOM1L1 TRAF6 TRAT1 TRPC6 TRPV4 TUBA1B TUBA3C TUBA4A TXK TYK2 TYRO3 UHRF2 UNC119 VAV1 VAV2 WAS WASF1 WASF2 WBP11 YTHDC1 ZAP70
Entrez ID		7124	2534
HPRD ID		01855	00655
Ensembl ID		ENSG00000232810	ENSG00000010810
Uniprot IDs		P01375 Q5STB3	P06241 Q5R3A8
PDB IDs		1A8M 1TNF 2AZ5 2E7A 2TUN 2ZJC 2ZPX 3ALQ 3IT8 3L9J 3WD5 4G3Y 4TSV 5TSW	1A0N 1AOT 1AOU 1AVZ 1AZG 1EFN 1FYN 1G83 1M27 1NYF 1NYG 1SHF 1ZBJ 2DQ7 3H0F 3H0H 3H0I 3UA6 3UA7 4D8D 4EIK
Enriched GO Terms of Interacting Partners?		Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Positive Regulation Of Cellular Protein Metabolic Process Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Response To Bacterium Positive Regulation Of Intracellular Signal Transduction Response To Tumor Necrosis Factor Immune Response Immune System Process Apoptotic Process Regulation Of Protein Metabolic Process Cellular Response To Lipopolysaccharide Regulation Of Intracellular Signal Transduction Response To Other Organism Programmed Cell Death Regulation Of Signal Transduction Cellular Response To Molecule Of Bacterial Origin Response To Biotic Stimulus Cell Death Death Cellular Response To Organic Substance Regulation Of Apoptotic Process Regulation Of Cytokine Production Apoptotic Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Death Response To Lipid Regulation Of Signaling Response To Organic Substance Cellular Response To Tumor Necrosis Factor Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Immune System Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Extrinsic Apoptotic Signaling Pathway Regulation Of Immune System Process Cellular Response To Lipid Defense Response Positive Regulation Of Metabolic Process Response To Stress Positive Regulation Of Protein Phosphorylation Leukocyte Activation Regulation Of Protein Phosphorylation Positive Regulation Of Proteolysis Regulation Of Protein Localization Positive Regulation Of Membrane Protein Ectodomain Proteolysis Innate Immune Response Leukocyte Differentiation Positive Regulation Of Phosphorylation	Signaling Signal Transduction Cell Communication Regulation Of Immune System Process Response To Stimulus Cellular Response To Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Immune System Process Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of Immune System Process Locomotion Regulation Of Signal Transduction Regulation Of Signaling Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response Movement Of Cell Or Subcellular Component Positive Regulation Of Immune Response Defense Response Positive Regulation Of Signal Transduction Innate Immune Response Cell Activation Blood Coagulation Antigen Receptor-mediated Signaling Pathway Hemostasis Fc Receptor Signaling Pathway Response To Wounding Response To Stress Wound Healing Response To Organic Substance Cell Migration Cell Differentiation Intracellular Signal Transduction Cell Motility Regulation Of Body Fluid Levels Response To External Stimulus Regulation Of Cellular Process Developmental Process Regulation Of Cell-cell Adhesion Regulation Of Intracellular Signal Transduction Regulation Of Cell Adhesion Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Response To Organic Substance Regulation Of Phosphorylation Anatomical Structure Development Regulation Of Cell Activation Regulation Of Cellular Component Organization
Tagcloud ?		aminopurine ap catalytically cooperate cotreatment de elicit endothelial exert gamma ifn ikappabbeta inactive inducible involves kappab neuronal normally novo pkr possibility potentiate require stranded synergistic synergistically translocation ultimately	293t analyzing anchoring aspartate binds coclusters coexpressed family implicated involves learning lyn mediate member nmda nr2a participates plasticity promotes psd ptk ptks scaffold serving src substrate synaptic tyrosine yes
Tagcloud (Difference) ?		aminopurine ap catalytically cooperate cotreatment de elicit endothelial exert gamma ifn ikappabbeta inactive inducible kappab neuronal normally novo pkr possibility potentiate require stranded synergistic synergistically translocation ultimately	293t analyzing anchoring aspartate binds coclusters coexpressed family implicated learning lyn mediate member nmda nr2a participates plasticity promotes psd ptk ptks scaffold serving src substrate synaptic tyrosine yes
Tagcloud (Intersection) ?		involves