TNF and CYB5R3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TNF	CYB5R3
Description		tumor necrosis factor	cytochrome b5 reductase 3
Image
GO Annotations	Cellular Component	Phagocytic Cup Extracellular Region Extracellular Space Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Protein-containing Complex Neuronal Cell Body Membrane Raft Recycling Endosome	Extracellular Region Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Cytosol Hemoglobin Complex Membrane Mitochondrial Membrane Azurophil Granule Lumen Nitric-oxide Synthase Complex
	Molecular Function	Transcription Cis-regulatory Region Binding Protease Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Death Receptor Agonist Activity Identical Protein Binding Receptor Ligand Activity	Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Protein Binding Oxidoreductase Activity Nitrite Reductase (NO-forming) Activity FAD Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Hypoxia Microglial Cell Activation Positive Regulation Of Cytokine Production Positive Regulation Of Protein Phosphorylation Negative Regulation Of Endothelial Cell Proliferation Negative Regulation Of L-glutamate Import Across Plasma Membrane Macrophage Activation Involved In Immune Response Chronic Inflammatory Response To Antigenic Stimulus Regulation Of Immunoglobulin Production Positive Regulation Of Immunoglobulin Production Negative Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Skeletal Muscle Contraction Negative Regulation Of Systemic Arterial Blood Pressure Glucose Metabolic Process Defense Response Inflammatory Response Immune Response Humoral Immune Response JNK Cascade Cell Surface Receptor Signaling Pathway Via JAK-STAT Circadian Rhythm Negative Regulation Of Cell Population Proliferation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Xenobiotic Stimulus Response To Mechanical Stimulus Response To Virus Response To Bacterium Response To Salt Stress Response To Fructose Animal Organ Morphogenesis Negative Regulation Of Heart Rate Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Lipid Storage Response To Activity Regulation Of Metabolic Process Calcium-mediated Signaling Extracellular Matrix Organization Osteoclast Differentiation Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Defense Response Positive Regulation Of Fever Generation Negative Regulation Of Myelination Response To Nutrient Levels Response To Lipopolysaccharide Negative Regulation Of Interleukin-6 Production Positive Regulation Of Chemokine Production Positive Regulation Of Fractalkine Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-18 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Heterotypic Cell-cell Adhesion Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Amide Metabolic Process Response To Isolation Stress Response To Macrophage Colony-stimulating Factor Non-canonical NF-kappaB Signal Transduction Regulation Of Cell Population Proliferation Vasodilation Defense Response To Bacterium Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Protein-containing Complex Disassembly Positive Regulation Of Protein-containing Complex Disassembly Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of JUN Kinase Activity Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Viral Genome Replication Innate Immune Response Cellular Extravasation Positive Regulation Of Nitric Oxide Biosynthetic Process Response To Ethanol Regulation Of Fat Cell Differentiation Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Myoblast Differentiation Negative Regulation Of Osteoblast Differentiation Regulation Of Osteoclast Differentiation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Protein Catabolic Process Positive Regulation Of Action Potential Positive Regulation Of Cell Adhesion Positive Regulation Of Lipid Metabolic Process Positive Regulation Of Mitotic Nuclear Division Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Translational Initiation By Iron Negative Regulation Of D-glucose Import Positive Regulation Of JNK Cascade Astrocyte Activation Embryonic Digestive Tract Development Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Protein Secretion Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Negative Regulation Of Neurogenesis Regulation Of Developmental Process Regulation Of Insulin Secretion Modulation Of Chemical Synaptic Transmission Positive Regulation Of Synaptic Transmission Regulation Of Synapse Organization Defense Response To Gram-positive Bacterium Cognition Leukocyte Migration Leukocyte Tethering Or Rolling Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Secretion Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Transport Regulation Of Multicellular Organismal Process Response To Glucocorticoid Positive Regulation Of Hair Follicle Development Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Glial Cell Proliferation Positive Regulation Of Vitamin D Biosynthetic Process Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Regulation Of Branching Involved In Salivary Gland Morphogenesis Negative Regulation Of Vascular Wound Healing Negative Regulation Of Branching Involved In Lung Morphogenesis Regulation Of Biological Quality Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Molecule Of Bacterial Origin Cellular Response To Lipopolysaccharide Cellular Response To Amino Acid Stimulus Cellular Response To Retinoic Acid Cellular Response To Nicotine Cellular Response To Type II Interferon Cellular Response To Ionizing Radiation Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Podosome Assembly Endothelial Cell Apoptotic Process Protein Localization To Plasma Membrane Negative Regulation Of Oxidative Phosphorylation Inflammatory Response To Wounding Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Cellular Response To Toxic Substance Liver Regeneration Necroptotic Signaling Pathway Negative Regulation Of Bile Acid Secretion Antiviral Innate Immune Response Response To Gram-negative Bacterium Positive Regulation Of Neuroinflammatory Response Positive Regulation Of Interleukin-33 Production Positive Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Amyloid-beta Clearance Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Synoviocyte Proliferation Positive Regulation Of Amyloid-beta Formation Response To L-glutamate Positive Regulation Of Neutrophil Activation Negative Regulation Of MiRNA Transcription Positive Regulation Of MiRNA Transcription Positive Regulation Of Protein Localization To Plasma Membrane Regulation Of Establishment Of Endothelial Barrier Negative Regulation Of Bicellular Tight Junction Assembly Positive Regulation Of Protein Localization Cellular Response To Amyloid-beta Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Regulation Of Membrane Lipid Metabolic Process Response To 3,3',5-triiodo-L-thyronine Response To Gold Nanoparticle Positive Regulation Of Protein Localization To Cell Surface Positive Regulation Of Blood Microparticle Formation Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Positive Regulation Of Hepatocyte Proliferation Regulation Of Endothelial Cell Apoptotic Process Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of DNA Biosynthetic Process Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Nitric Oxide Biosynthetic Process Blood Circulation Steroid Metabolic Process Cholesterol Metabolic Process Sterol Biosynthetic Process
Pathways		Transcriptional regulation of white adipocyte differentiation TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway TNFR1-mediated ceramide production TNFR2 non-canonical NF-kB pathway Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling TNF signaling Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	Vitamin C (ascorbate) metabolism Phase I - Functionalization of compounds Neutrophil degranulation
Drugs		Etanercept Adalimumab Infliximab Chloroquine Epinephrine Pseudoephedrine Clenbuterol Pranlukast Amrinone Trichostatin A Afelimomab YSIL6 SD118 PN0621 OMS-103HP Talmapimod VX-702 Atiprimod CRx-139 CYT007-TNFQb Andrographolide Ethyl pyruvate AME-527 PR-104 Plinabulin Dexanabinol Onercept Golimumab Certolizumab pegol Pomalidomide Polaprezinc Foreskin fibroblast (neonatal) Foreskin keratinocyte (neonatal) Bryostatin 1 Binimetinib Dilmapimod Glycyrrhizic acid	NADH Flavin adenine dinucleotide Copper
Diseases		Graft-versus-host disease Systemic lupus erythematosus Allograft rejection Asthma	Methemoglobinemia
GWAS		AIDS progression ( 19115949) Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Cervical cancer ( 28806749) Crohn's disease ( 21102463) Inflammatory bowel disease ( 28067908) Malaria ( 31844061) Neonatal lupus ( 20662065) Psychosis (atypical) ( 24132900) Pulse pressure ( 30578418) Type 1 diabetes (age at diagnosis) ( 33179336) Ulcerative colitis ( 28067908) Waist-to-hip ratio adjusted for BMI ( 34021172)	Initial pursuit acceleration ( 29064472)
Interacting Genes		64 interacting genes: ADAM17 ADAM9 AQP3 BCL2L13 BGN BIRC2 BTNL9 C10orf67 CCDC107 CCDC70 CLDN7 CLEC10A CREB3L1 CSF1 CYB5R3 DCN FAM209A FFAR2 FNDC9 FYN HNRNPD IFNG IKBKG KASH5 LMNA LRRC25 LRRTM2 LYN MMP14 MMP17 MRM3 NFKBIA PAGE1 PANX1 PDIK1L PIP4P2 PLEKHO1 POU2F1 PRTN3 RBCK1 RC3H1 RIPK1 RNF19B RNF31 S100A11 S100A12 S100A13 SEC61A1 SGCB SHARPIN SLC14A2 SLC30A4 SSMEM1 STOM STX1A TMPRSS2 TNFRSF1A TNFRSF1B TRAF2 TSG101 VSIR YWHAQ ZCCHC12 ZFP36	78 interacting genes: ADAM33 AGTRAP AIG1 ALG8 APOL3 AQP6 ASGR1 ATP13A1 BET1 BNIP2 CDIPT CERS4 CNIH1 COL8A2 CSGALNACT2 CYB561D2 CYB5A CYCS ELOVL4 FAM210B FAM3C FAXDC2 FUNDC2 FXYD3 GAST GPR152 GRM2 HBG2 HSD17B13 LAPTM5 LNPEP LRCH4 MFSD6 NINJ1 NRM NSG1 NXPE3 ORMDL2 PEX16 PLLP PLP1 PNLIPRP1 RABAC1 REEP4 REEP6 SLC10A1 SLC10A6 SLC13A3 SLC22A2 SLC30A3 SLC35A4 SLC35B2 SLC38A7 SPP1 STOM TMEM115 TMEM147 TMEM14B TMEM14C TMEM201 TMEM31 TMEM51 TMEM60 TMEM79 TNF TNFRSF10C UBIAD1 UNC50 UNC93B1 UPK1B UPK2 VAMP1 VAMP4 VAMP5 VMP1 WFDC2 YIPF4 ZDHHC15
Entrez ID		7124	1727
HPRD ID		01855	08942
Ensembl ID		ENSG00000232810	ENSG00000100243
Uniprot IDs		P01375 Q5STB3	P00387
PDB IDs		1A8M 1TNF 2AZ5 2E7A 2TUN 2ZJC 2ZPX 3ALQ 3IT8 3L9J 3WD5 4G3Y 4TSV 4TWT 4Y6O 5M2I 5M2J 5M2M 5MU8 5TSW 5UUI 5WUX 5YOY 6OOY 6OOZ 6OP0 6RMJ 6X81 6X82 6X83 6X85 6X86 7ASY 7AT7 7ATB 7JRA 7KP9 7KPA 7KPB 7QLF 7TA3 7TA6 8Z8M	1UMK 7THG 7TNV 7TSW 7W3O
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor Binding Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Immune System Process Regulation Of Canonical NF-kappaB Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Immune System Process Response To External Biotic Stimulus Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Tumor Necrosis Factor Receptor Superfamily Complex LUBAC Complex Defense Response Protein Binding Negative Regulation Of Necroptotic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Inflammatory Response Activation Of Immune Response Negative Regulation Of Programmed Necrotic Cell Death Positive Regulation Of Cell Communication Positive Regulation Of Signaling Immune Response-activating Signaling Pathway Protein Linear Polyubiquitination Membrane Raft Response To Stress Ubiquitin Binding Canonical NF-kappaB Signal Transduction Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Cytokine Production T Cell Receptor Signaling Pathway Identical Protein Binding Regulation Of Immune Response Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Necroptotic Process Immune Response-regulating Signaling Pathway Non-canonical NF-kappaB Signal Transduction CD40 Receptor Complex Response To Other Organism Regulation Of DNA-binding Transcription Factor Activity Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Protein-containing Complex Binding Regulation Of Programmed Necrotic Cell Death Immune System Process Positive Regulation Of Immune Response Calcium-dependent Protein Binding Proteolysis Regulation Of Multicellular Organismal Process Positive Regulation Of Membrane Protein Ectodomain Proteolysis	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Cytoplasmic Vesicle Membrane Golgi Apparatus Protein Binding Establishment Of Protein Localization To Membrane Golgi Membrane Bile Acid:sodium Symporter Activity Cytoplasmic Vesicle Carboxylic Acid Transport Organic Acid Transport Organic Anion Transport
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