TNF and ADAM9

Number of citations of the paper that reports this interaction (PMID 9920899)
34

Data Source:
HPRD (in vitro)

		TNF	ADAM9
Gene Name		tumor necrosis factor	ADAM metallopeptidase domain 9
Image
Gene Ontology Annotations	Cellular Component	Phagocytic Cup Extracellular Region Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Raft Recycling Endosome	Extracellular Space Cytoplasm Focal Adhesion Cell Surface Integral Component Of Membrane Basolateral Plasma Membrane Intrinsic Component Of External Side Of Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Protease Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Identical Protein Binding Transcription Regulatory Region DNA Binding	Metalloendopeptidase Activity Protein Kinase C Binding Integrin Binding Protein Binding Collagen Binding Metallopeptidase Activity Zinc Ion Binding SH3 Domain Binding Laminin Binding
	Biological Process	Protein Import Into Nucleus, Translocation Negative Regulation Of Transcription From RNA Polymerase II Promoter MAPK Cascade Activation Of MAPKKK Activity Activation Of MAPK Activity Response To Hypoxia Cell Activation Positive Regulation Of Cytokine Production Positive Regulation Of Protein Phosphorylation Negative Regulation Of L-glutamate Transport Chronic Inflammatory Response To Antigenic Stimulus Negative Regulation Of Cytokine Secretion Involved In Immune Response Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Skeletal Muscle Contraction Glucose Metabolic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Transformed Cell Apoptotic Process Inflammatory Response Humoral Immune Response JNK Cascade Negative Regulation Of Cell Proliferation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Radiation Response To Virus Response To Salt Stress Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Alkaline Phosphatase Activity Negative Regulation Of Lipid Storage Response To Activity Calcium-mediated Signaling Extracellular Matrix Organization Osteoclast Differentiation Sequestering Of Triglyceride Positive Regulation Of Protein Complex Assembly Positive Regulation Of Fever Generation Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Interleukin-6 Production Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-18 Production Positive Regulation Of Interleukin-6 Production Receptor Biosynthetic Process Positive Regulation Of Peptidyl-serine Phosphorylation Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Heterotypic Cell-cell Adhesion Positive Regulation Of NF-kappaB Import Into Nucleus Response To Drug Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Protein Complex Disassembly Positive Regulation Of Protein Complex Disassembly Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of MAP Kinase Activity Protein Kinase B Signaling Positive Regulation Of JUN Kinase Activity Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Growth Of Symbiont In Host Negative Regulation Of Viral Genome Replication Positive Regulation Of Chemokine Biosynthetic Process Positive Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Myoblast Differentiation Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Action Potential Positive Regulation Of Mitotic Nuclear Division Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Translational Initiation By Iron Negative Regulation Of Glucose Import Embryonic Digestive Tract Development Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Cytokine Secretion Positive Regulation Of Phagocytosis Regulation Of Insulin Secretion Positive Regulation Of Synaptic Transmission Defense Response To Gram-positive Bacterium Leukocyte Tethering Or Rolling Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Negative Regulation Of Lipid Catabolic Process Regulation Of Immunoglobulin Secretion Positive Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Transport Response To Glucocorticoid Positive Regulation Of NFAT Protein Import Into Nucleus Positive Regulation Of Hair Follicle Development Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Vitamin D Biosynthetic Process Positive Regulation Of Calcidiol 1-monooxygenase Activity Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Regulation Of Branching Involved In Salivary Gland Morphogenesis Negative Regulation Of Branching Involved In Lung Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Amino Acid Stimulus Cellular Response To Nicotine Cellular Response To Organic Cyclic Compound Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Podosome Assembly Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Necroptotic Signaling Pathway Response To Gold Nanoparticle Positive Regulation Of Protein Localization To Cell Surface Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Activation Of MAPKK Activity Membrane Protein Ectodomain Proteolysis Cell Adhesion Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Response To Manganese Ion Extracellular Matrix Disassembly Extracellular Matrix Organization Keratinocyte Differentiation Collagen Catabolic Process Cell Adhesion Mediated By Integrin Positive Regulation Of Cell Adhesion Mediated By Integrin Cell-cell Adhesion Mediated By Integrin Positive Regulation Of Macrophage Fusion Response To Tumor Necrosis Factor Response To Laminar Fluid Shear Stress Monocyte Activation Response To Hydrogen Peroxide Positive Regulation Of Protein Secretion Positive Regulation Of Membrane Protein Ectodomain Proteolysis PMA-inducible Membrane Protein Ectodomain Proteolysis Response To Glucocorticoid Positive Regulation Of Keratinocyte Migration Response To Calcium Ion Cellular Response To Lipopolysaccharide
Pathways		TNF signaling Death Receptor Signalling Transcriptional regulation of white adipocyte differentiation Programmed Cell Death Extrinsic Pathway	Collagen degradation Degradation of the extracellular matrix
Drugs		Etanercept Adalimumab Infliximab Chloroquine Thalidomide Glucosamine Clenbuterol Pranlukast Amrinone golimumab Certolizumab pegol Pomalidomide
Diseases
GWAS		AIDS progression ( 19115949) Crohn's disease ( 21102463) Neonatal lupus ( 20662065)
Protein-Protein Interactions		21 interactors: ADAM17 ADAM9 BGN CSF1 DCN FYN IFNG LYN MMP17 NFKBIA PDIK1L POU2F1 PRTN3 RC3H1 RIPK1 TNFAIP3 TNFRSF1A TNFRSF1B TRADD TRAF2 YWHAQ	9 interactors: ITGA3 ITGA6 ITGAV MAD2L2 PRKCD SH3D19 SH3GLB1 SNX9 TNF
Entrez ID		7124	8754
HPRD ID		01855	04091
Ensembl ID		ENSG00000232810	ENSG00000168615
Uniprot IDs		P01375 Q5STB3	Q13443
PDB IDs		1A8M 1TNF 2AZ5 2E7A 2TUN 2ZJC 2ZPX 3ALQ 3IT8 3L9J 3WD5 4G3Y 4TSV 5TSW	1M1V
Enriched GO Terms of Interacting Partners?		Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Positive Regulation Of Cellular Protein Metabolic Process Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Response To Bacterium Positive Regulation Of Intracellular Signal Transduction Response To Tumor Necrosis Factor Immune Response Immune System Process Apoptotic Process Regulation Of Protein Metabolic Process Cellular Response To Lipopolysaccharide Regulation Of Intracellular Signal Transduction Response To Other Organism Programmed Cell Death Regulation Of Signal Transduction Cellular Response To Molecule Of Bacterial Origin Response To Biotic Stimulus Cell Death Death Cellular Response To Organic Substance Regulation Of Apoptotic Process Regulation Of Cytokine Production Apoptotic Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Death Response To Lipid Regulation Of Signaling Response To Organic Substance Cellular Response To Tumor Necrosis Factor Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Immune System Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Extrinsic Apoptotic Signaling Pathway Regulation Of Immune System Process Cellular Response To Lipid Defense Response Positive Regulation Of Metabolic Process Response To Stress Positive Regulation Of Protein Phosphorylation Leukocyte Activation Regulation Of Protein Phosphorylation Positive Regulation Of Proteolysis Regulation Of Protein Localization Positive Regulation Of Membrane Protein Ectodomain Proteolysis Innate Immune Response Leukocyte Differentiation Positive Regulation Of Phosphorylation	Positive Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Cellular Component Organization Regulation Of Cell Adhesion Negative Regulation Of Signal Transduction Leukocyte Migration Negative Regulation Of Signaling Regulation Of Protein Complex Assembly Extracellular Matrix Organization Regulation Of Cell-cell Adhesion Extracellular Structure Organization Positive Regulation Of Cell Adhesion Regulation Of Protein Catabolic Process Integrin-mediated Signaling Pathway Blood Coagulation Hemostasis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Lipid Storage Positive Regulation Of Protein Oligomerization Positive Regulation Of Cellular Protein Metabolic Process Cell-matrix Adhesion Positive Regulation Of Protein Complex Assembly Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Body Fluid Levels Regulation Of Protein Metabolic Process Wound Healing Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Protein Oligomerization Regulation Of Phosphorylation Cell-substrate Adhesion Positive Regulation Of Protein Catabolic Process Regulation Of Proteolysis Response To Wounding Regulation Of Phosphorus Metabolic Process Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Phagocytosis Positive Regulation Of Proteolysis Regulation Of Signal Transduction Cell Migration Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Phosphorylation Regulation Of Lipid Catabolic Process Positive Regulation Of Cell Migration Regulation Of Lipid Storage Positive Regulation Of Cell Motility Cell Motility Positive Regulation Of Protein Modification Process Positive Regulation Of Lipid Biosynthetic Process Negative Regulation Of Apoptotic Process
Tagcloud ?		aminopurine ap catalytically cooperate cotreatment de elicit endothelial exert gamma ifn ikappabbeta inactive inducible involves kappab neuronal normally novo pkr possibility potentiate require stranded synergistic synergistically translocation ultimately	aurka birc5 c11orf30 ccne1 cdc6 cdh1 cpd devoid emsy esr1 fgfr1 holland ikbkb mapt mathematical meaning med1 microdissection mlpa mrc mtdh multiplex numerical p078 prdm14 qiagen salsa top2a traf4
Tagcloud (Difference) ?		aminopurine ap catalytically cooperate cotreatment de elicit endothelial exert gamma ifn ikappabbeta inactive inducible involves kappab neuronal normally novo pkr possibility potentiate require stranded synergistic synergistically translocation ultimately	aurka birc5 c11orf30 ccne1 cdc6 cdh1 cpd devoid emsy esr1 fgfr1 holland ikbkb mapt mathematical meaning med1 microdissection mlpa mrc mtdh multiplex numerical p078 prdm14 qiagen salsa top2a traf4
Tagcloud (Intersection) ?