PTX3 and FGF5

Number of citations of the paper that reports this interaction (PubMedID 25912421)
45

Data Source:
BioGRID (pull down)

		PTX3	FGF5
Description		pentraxin 3	fibroblast growth factor 5
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Specific Granule Lumen Tertiary Granule Lumen	Extracellular Region Extracellular Space Cytoplasm
	Molecular Function	Complement Component C1q Complex Binding (1->3)-beta-D-glucan Binding Protein Binding Identical Protein Binding Virion Binding	Fibroblast Growth Factor Receptor Binding Growth Factor Activity
	Biological Process	Ovarian Cumulus Expansion Response To Yeast Immune System Process Inflammatory Response Immune Response Opsonization Extracellular Matrix Organization Host-mediated Suppression Of Viral Proces Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Host-mediated Suppression Of Symbiont Invasion Positive Regulation Of Phagocytosis Response To Other Organism Negative Regulation Of Glycoprotein Metabolic Process	Signal Transduction Cell-cell Signaling Nervous System Development Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Glial Cell Differentiation Neurogenesis Signal Transduction Involved In Regulation Of Gene Expression Regulation Of Cell Migration Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Division
Pathways		Neutrophil degranulation
Drugs
Diseases
GWAS		Body mass index ( 26426971)	Apolipoprotein B levels ( 32203549) Atrial fibrillation ( 29892015 30061737) Blond vs. brown/black hair color ( 30531825) Blood pressure ( 21909110 24954895) Blood urea nitrogen levels ( 29403010 31152163) Chronic kidney disease ( 31152163) Coronary artery disease ( 28714974 29212778 32469254 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Creatinine levels ( 29403010) Diastolic blood pressure ( 28871152 28135244 28739976 29403010 27841878 19430483 27736895 27618452 27618447 30487518 26390057 25249183 21909115) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Estimated glomerular filtration rate ( 31152163 30604766 31015462 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glomerular filtration rate ( 29403010) Gout (combined type) ( 32238385) Hemoglobin levels ( 32327693) Hypertension ( 32709000 30487518 25249183) LDL cholesterol levels ( 32203549) Male-pattern baldness ( 28196072 27182965 29146897) Mean arterial pressure ( 30487518 29403010 28871152 26390057) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Monobrow ( 27182965) Myocardial infarction ( 33532862) Potassium levels ( 29403010) PR interval ( 32439900) Pulse pressure ( 30487518 28739976 27841878 29403010 30578418) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Red blood cell count ( 29403010) Refractive error ( 32231278) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Serum uric acid levels ( 30993211 29403010) Systolic blood pressure ( 29403010 21909115 28871152 28135244 27841878 27736895 25249183 27618452 28739976 30487518 26390057 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Urate levels ( 31578528 31985003 23263486)
Interacting Genes		16 interacting genes: C1QA C1QB C1QC CFH FGF1 FGF16 FGF17 FGF18 FGF2 FGF20 FGF22 FGF5 FGF7 FGF8 MTNR1A SNCA	5 interacting genes: FGFR1 FGFR2 FGFR3 FGFR4 PTX3
Entrez ID		5806	2250
HPRD ID		03928	01307
Ensembl ID		ENSG00000163661	ENSG00000138675
Uniprot IDs		P26022	P12034 Q8NBG6
PDB IDs		7ZL1 8PVQ 8S50
Enriched GO Terms of Interacting Partners?		Fibroblast Growth Factor Receptor Signaling Pathway Neurogenesis Growth Factor Activity Fibroblast Growth Factor Receptor Binding Extracellular Region Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of MAPK Cascade Type 2 Fibroblast Growth Factor Receptor Binding Extracellular Space Cell-cell Signaling Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Signaling Enzyme-linked Receptor Protein Signaling Pathway Cell Communication Regulation Of MAPK Cascade Regulation Of Locomotion Complement Component C1q Complex Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Positive Regulation Of Cell Population Proliferation Symbiont Cell Surface Regulation Of Cell Migration Regulation Of Cell Motility IgM Binding Complement Component C1 Complex Positive Regulation Of Intracellular Signal Transduction Type 1 Fibroblast Growth Factor Receptor Binding Positive Regulation Of Cell Division Lung Development Postsynapse Positive Regulation Of Cell Communication Positive Regulation Of Signaling Synapse Pruning Complement Activation Regulation Of Sprouting Angiogenesis IgG Binding Positive Regulation Of Signal Transduction Positive Regulation Of Endothelial Cell Chemotaxis Regulation Of Cell Population Proliferation Regulation Of MAP Kinase Activity Regulation Of Cell Division Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Animal Organ Morphogenesis Organ Induction Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Animal Organ Formation Corticotropin Hormone Secreting Cell Differentiation Developmental Induction Chemoattractant Activity Positive Regulation Of Endothelial Cell Migration	Fibroblast Growth Factor Receptor Activity Fibroblast Growth Factor Binding Positive Regulation Of Phospholipase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Lipase Activity Fibroblast Growth Factor Receptor Signaling Pathway Protein Tyrosine Kinase Activity Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Receptor Complex Ventricular Zone Neuroblast Division Orbitofrontal Cortex Development Peptidyl-tyrosine Phosphorylation Positive Regulation Of Catalytic Activity Forebrain Neuroblast Division Forebrain Ventricular Zone Progenitor Cell Division Biomineral Tissue Development Lung-associated Mesenchyme Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of MAPK Cascade Endochondral Bone Growth Positive Regulation Of Hydrolase Activity Protein Autophosphorylation Protein Kinase Activity Branching Involved In Salivary Gland Morphogenesis Regulation Of Catalytic Activity Heparin Binding Kinase Activity Bone Growth Enzyme-linked Receptor Protein Signaling Pathway Regulation Of MAPK Cascade Positive Regulation Of ERK1 And ERK2 Cascade Mesenchymal Cell Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Extracellular Region Gland Morphogenesis Cellular Response To Fibroblast Growth Factor Stimulus Midbrain Development Positive Regulation Of Cell Population Proliferation Regulation Of Mesenchymal Cell Proliferation Bone Morphogenesis Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Heart Growth Response To Fibroblast Growth Factor Ureteric Bud Development Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Developmental Growth Mesonephric Tubule Development Mesonephric Epithelium Development Positive Regulation Of Organ Growth
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