PTX3 and FGF22

Number of citations of the paper that reports this interaction (PubMedID 25912421)
45

Data Source:
BioGRID (pull down)

		PTX3	FGF22
Description		pentraxin 3	fibroblast growth factor 22
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Specific Granule Lumen Tertiary Granule Lumen	Extracellular Region Extracellular Space Nucleolus Cytoplasm Golgi Apparatus Cell Surface Postsynapse Glutamatergic Synapse GABA-ergic Synapse Extrinsic Component Of Postsynaptic Density Membrane
	Molecular Function	Complement Component C1q Complex Binding (1->3)-beta-D-glucan Binding Protein Binding Identical Protein Binding Virion Binding	Fibroblast Growth Factor Receptor Binding Growth Factor Activity
	Biological Process	Ovarian Cumulus Expansion Response To Yeast Immune System Process Inflammatory Response Immune Response Opsonization Extracellular Matrix Organization Host-mediated Suppression Of Viral Proces Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Host-mediated Suppression Of Symbiont Invasion Positive Regulation Of Phagocytosis Response To Other Organism Negative Regulation Of Glycoprotein Metabolic Process	Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Neurogenesis Cell Differentiation Regulation Of Cell Migration Positive Regulation Of MAPK Cascade Regulation Of Synapse Maturation Trans-synaptic Signaling
Pathways		Neutrophil degranulation	PI3K Cascade PIP3 activates AKT signaling FGFR1b ligand binding and activation FGFR2b ligand binding and activation Activated point mutants of FGFR2 Constitutive Signaling by Aberrant PI3K in Cancer Phospholipase C-mediated cascade: FGFR1 Phospholipase C-mediated cascade; FGFR2 Downstream signaling of activated FGFR1 SHC-mediated cascade:FGFR1 PI-3K cascade:FGFR1 FRS-mediated FGFR1 signaling PI-3K cascade:FGFR2 SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Signaling by FGFR2 in disease FGFRL1 modulation of FGFR1 signaling RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs
Diseases
GWAS		Body mass index ( 26426971)
Interacting Genes		16 interacting genes: C1QA C1QB C1QC CFH FGF1 FGF16 FGF17 FGF18 FGF2 FGF20 FGF22 FGF5 FGF7 FGF8 MTNR1A SNCA	1 interacting genes: PTX3
Entrez ID		5806	27006
HPRD ID		03928	05784
Ensembl ID		ENSG00000163661	ENSG00000070388
Uniprot IDs		P26022	K7ELB9 Q9HCT0
PDB IDs		7ZL1 8PVQ 8S50
Enriched GO Terms of Interacting Partners?		Fibroblast Growth Factor Receptor Signaling Pathway Neurogenesis Growth Factor Activity Fibroblast Growth Factor Receptor Binding Extracellular Region Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of MAPK Cascade Type 2 Fibroblast Growth Factor Receptor Binding Extracellular Space Cell-cell Signaling Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Signaling Enzyme-linked Receptor Protein Signaling Pathway Cell Communication Regulation Of MAPK Cascade Regulation Of Locomotion Complement Component C1q Complex Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Positive Regulation Of Cell Population Proliferation Symbiont Cell Surface Regulation Of Cell Migration Regulation Of Cell Motility IgM Binding Complement Component C1 Complex Positive Regulation Of Intracellular Signal Transduction Type 1 Fibroblast Growth Factor Receptor Binding Positive Regulation Of Cell Division Lung Development Postsynapse Positive Regulation Of Cell Communication Positive Regulation Of Signaling Synapse Pruning Complement Activation Regulation Of Sprouting Angiogenesis IgG Binding Positive Regulation Of Signal Transduction Positive Regulation Of Endothelial Cell Chemotaxis Regulation Of Cell Population Proliferation Regulation Of MAP Kinase Activity Regulation Of Cell Division Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Animal Organ Morphogenesis Organ Induction Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Animal Organ Formation Corticotropin Hormone Secreting Cell Differentiation Developmental Induction Chemoattractant Activity Positive Regulation Of Endothelial Cell Migration	Negative Regulation By Host Of Viral Glycoprotein Metabolic Process (1->3)-beta-D-glucan Binding Ovarian Cumulus Expansion Complement Component C1q Complex Binding Virion Binding Negative Regulation Of Glycoprotein Metabolic Process Opsonization Host-mediated Suppression Of Viral Proces Response To Yeast Host-mediated Suppression Of Symbiont Invasion Ovulation Cycle Process Positive Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Specific Granule Lumen Tertiary Granule Lumen Response To Fungus Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Phagocytosis Host-mediated Perturbation Of Viral Process Negative Regulation Of Viral Process Regulation Of Phagocytosis Host-mediated Perturbation Of Symbiont Process Modulation Of Process Of Another Organism Regulation Of Viral Process Positive Regulation Of Endocytosis Extracellular Matrix Organization Rhythmic Process Extracellular Structure Organization Regulation Of Endocytosis
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