PTX3 and FGF8

Number of citations of the paper that reports this interaction (PubMedID 25912421)
45

Data Source:
BioGRID (pull down)

		PTX3	FGF8
Description		pentraxin 3	fibroblast growth factor 8
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Specific Granule Lumen Tertiary Granule Lumen	Extracellular Region Extracellular Space Cytoplasm External Side Of Plasma Membrane
	Molecular Function	Complement Component C1q Complex Binding (1->3)-beta-D-glucan Binding Protein Binding Identical Protein Binding Virion Binding	Type 1 Fibroblast Growth Factor Receptor Binding Type 2 Fibroblast Growth Factor Receptor Binding Growth Factor Activity Chemoattractant Activity
	Biological Process	Ovarian Cumulus Expansion Response To Yeast Immune System Process Inflammatory Response Immune Response Opsonization Extracellular Matrix Organization Host-mediated Suppression Of Viral Proces Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Host-mediated Suppression Of Symbiont Invasion Positive Regulation Of Phagocytosis Response To Other Organism Negative Regulation Of Glycoprotein Metabolic Process	MAPK Cascade Branching Involved In Blood Vessel Morphogenesis Metanephros Development Branching Involved In Ureteric Bud Morphogenesis Organ Induction Kidney Development Mesonephros Development Neural Plate Morphogenesis Heart Looping Blood Vessel Remodeling Heart Morphogenesis Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Apoptotic Process Response To Oxidative Stress Signal Transduction Determination Of Left/right Symmetry Gastrulation Heart Development Motor Neuron Axon Guidance Mesodermal Cell Migration Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Gonad Development Fibroblast Growth Factor Receptor Signaling Pathway Response To Xenobiotic Stimulus Anatomical Structure Morphogenesis Embryo Development Ending In Birth Or Egg Hatching Dorsal/ventral Pattern Formation Positive Regulation Of Gene Expression Telencephalon Development Pallium Development Subpallium Development Forebrain Dorsal/ventral Pattern Formation Cell Proliferation In Forebrain Forebrain Neuron Development Central Nervous System Neuron Development Neurogenesis Signal Transduction Involved In Regulation Of Gene Expression Cell Differentiation Lung Development Regulation Of Cell Migration Male Genitalia Development Thyroid Gland Development Otic Vesicle Formation Midbrain-hindbrain Boundary Development Dorsal/ventral Axon Guidance Embryonic Heart Tube Development Limb Morphogenesis Embryonic Hindlimb Morphogenesis Organ Growth Aorta Morphogenesis Inner Ear Morphogenesis Odontogenesis Regulation Of Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Cell Fate Commitment Positive Regulation Of Cell Differentiation Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Organ Growth Generation Of Neurons Embryonic Neurocranium Morphogenesis Forebrain Morphogenesis Positive Chemotaxis Neuron Apoptotic Process Positive Regulation Of Cell Division Negative Regulation Of Cardiac Muscle Tissue Development Pharyngeal System Development Corticotropin Hormone Secreting Cell Differentiation Thyroid-stimulating Hormone-secreting Cell Differentiation Bone Development Lung Morphogenesis Branching Involved In Salivary Gland Morphogenesis Neuroepithelial Cell Differentiation Positive Regulation Of ERK1 And ERK2 Cascade Dopaminergic Neuron Differentiation Stem Cell Proliferation Cell Migration Involved In Mesendoderm Migration Larynx Morphogenesis Mitotic Nuclear Division Positive Regulation Of Stem Cell Proliferation
Pathways		Neutrophil degranulation	Formation of the posterior neural plate
Drugs
Diseases			Hypogonadotropic hypogonadism; Kallmann syndrome (KAL)
GWAS		Body mass index ( 26426971)	General cognitive ability ( 29844566) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Systolic blood pressure ( 30578418)
Interacting Genes		16 interacting genes: C1QA C1QB C1QC CFH FGF1 FGF16 FGF17 FGF18 FGF2 FGF20 FGF22 FGF5 FGF7 FGF8 MTNR1A SNCA	5 interacting genes: FGFR1 FGFR2 FGFR3 FGFR4 PTX3
Entrez ID		5806	2253
HPRD ID		03928	02727
Ensembl ID		ENSG00000163661	ENSG00000107831
Uniprot IDs		P26022	A0A087X1S5 A1A515 P55075
PDB IDs		7ZL1 8PVQ 8S50	2FDB
Enriched GO Terms of Interacting Partners?		Fibroblast Growth Factor Receptor Signaling Pathway Neurogenesis Growth Factor Activity Fibroblast Growth Factor Receptor Binding Extracellular Region Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of MAPK Cascade Type 2 Fibroblast Growth Factor Receptor Binding Extracellular Space Cell-cell Signaling Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Signaling Enzyme-linked Receptor Protein Signaling Pathway Cell Communication Regulation Of MAPK Cascade Regulation Of Locomotion Complement Component C1q Complex Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Positive Regulation Of Cell Population Proliferation Symbiont Cell Surface Regulation Of Cell Migration Regulation Of Cell Motility IgM Binding Complement Component C1 Complex Positive Regulation Of Intracellular Signal Transduction Type 1 Fibroblast Growth Factor Receptor Binding Positive Regulation Of Cell Division Lung Development Postsynapse Positive Regulation Of Cell Communication Positive Regulation Of Signaling Synapse Pruning Complement Activation Regulation Of Sprouting Angiogenesis IgG Binding Positive Regulation Of Signal Transduction Positive Regulation Of Endothelial Cell Chemotaxis Regulation Of Cell Population Proliferation Regulation Of MAP Kinase Activity Regulation Of Cell Division Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Animal Organ Morphogenesis Organ Induction Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Animal Organ Formation Corticotropin Hormone Secreting Cell Differentiation Developmental Induction Chemoattractant Activity Positive Regulation Of Endothelial Cell Migration	Fibroblast Growth Factor Receptor Activity Fibroblast Growth Factor Binding Positive Regulation Of Phospholipase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Lipase Activity Fibroblast Growth Factor Receptor Signaling Pathway Protein Tyrosine Kinase Activity Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Receptor Complex Ventricular Zone Neuroblast Division Orbitofrontal Cortex Development Peptidyl-tyrosine Phosphorylation Positive Regulation Of Catalytic Activity Forebrain Neuroblast Division Forebrain Ventricular Zone Progenitor Cell Division Biomineral Tissue Development Lung-associated Mesenchyme Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of MAPK Cascade Endochondral Bone Growth Positive Regulation Of Hydrolase Activity Protein Autophosphorylation Protein Kinase Activity Branching Involved In Salivary Gland Morphogenesis Regulation Of Catalytic Activity Heparin Binding Kinase Activity Bone Growth Enzyme-linked Receptor Protein Signaling Pathway Regulation Of MAPK Cascade Positive Regulation Of ERK1 And ERK2 Cascade Mesenchymal Cell Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Extracellular Region Gland Morphogenesis Cellular Response To Fibroblast Growth Factor Stimulus Midbrain Development Positive Regulation Of Cell Population Proliferation Regulation Of Mesenchymal Cell Proliferation Bone Morphogenesis Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Heart Growth Response To Fibroblast Growth Factor Ureteric Bud Development Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Developmental Growth Mesonephric Tubule Development Mesonephric Epithelium Development Positive Regulation Of Organ Growth
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