EFEMP1 and TNIP1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		EFEMP1	TNIP1
Description		EGF-like fibulin extracellular matrix protein 1	TNFAIP3 interacting protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Epidermal Growth Factor Receptor Activity Epidermal Growth Factor Receptor Binding Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Growth Factor Activity	Protein Binding Identical Protein Binding Mitogen-activated Protein Kinase Binding
	Biological Process	Regulation Of DNA-templated Transcription Epidermal Growth Factor Receptor Signaling Pathway Visual Perception Peptidyl-tyrosine Phosphorylation Negative Regulation Of Chondrocyte Differentiation Camera-type Eye Development Embryonic Eye Morphogenesis Post-embryonic Eye Morphogenesis	MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Transcription By RNA Polymerase II Translation Defense Response Inflammatory Response Leukocyte Cell-cell Adhesion Glycoprotein Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Viral Genome Replication Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Inflammatory Response Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Regulation Of Primary Metabolic Process Positive Regulation Of Protein Deubiquitination
Pathways		Molecules associated with elastic fibres Molecules associated with elastic fibres	Ovarian tumor domain proteases
Drugs
Diseases		Familial flecked retina syndrome, including: Doyne honeycomb degeneration of retina (DHRD); Basal laminar drusen (BLD); Fundus albipunctatus (FA); Retinitis punctata albescens (RPA); Bietti crystalline corneoretinal dystrophy (BCD)
GWAS		A body shape index ( 34021172) Amyotrophic lateral sclerosis ( 19451621) Appendicular lean mass ( 33097823) Blood protein levels ( 30072576) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Carpal tunnel syndrome ( 30833571) Childhood ear infection ( 27182965 28928442) Chronic venous disease ( 28374850) Deep white matter hyperintensities ( 32517579) Diastolic blood pressure ( 30578418) Diverticular disease ( 30177863) FEV1 ( 30804560) Glaucoma (primary open-angle) ( 33627673) Height ( 18391952 31562340 28552196 33713608 34270706 25429064 18391951 19396169 19893584 20189936 20397748 20881960 23563607 25282103) Hip circumference adjusted for BMI ( 34021172 25673412) Inguinal hernia ( 26686553) Intraocular pressure ( 29235454 29617998 29785010 30054594) Joint mobility (Beighton score) ( 27182965) Lung function (FEV1/FVC) ( 30804560) Lung function (forced vital capacity) ( 24929828) Lung function (FVC) ( 30804560) Lung volume ( 34128465) Metabolite levels ( 23823483) Optic cup area ( 28073927 25631615) Pelvic organ prolapse ( 32184442) Pelvic organ prolapse (moderate/severe) ( 26545240) Periventricular white matter hyperintensities ( 32517579) Pulse pressure ( 27841878 30578418) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for BMI in smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 26785701 28552196 34021172 28448500) Waist-hip index ( 34021172) White matter hyperintensities ( 32358547) White matter hyperintensity burden ( 25663218) White matter hyperintensity volume ( 33293549 29752348 30659137) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549) Youthful appearance (self-reported) ( 32339537)	Amyotrophic lateral sclerosis ( 29566793) Autoimmune traits (pleiotropy) ( 30572963) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Cutaneous psoriasis ( 26626624) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Inflammatory bowel disease ( 23128233 28067908) Inflammatory skin disease ( 25574825) LDL cholesterol levels in HIV infection ( 33109212) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Myasthenia gravis ( 23055271) Neutrophil percentage of granulocytes ( 27863252) Psoriasis ( 25903422 25854761 25574825 23143594 19169254) Psoriasis vulgaris ( 26626624 29031612) Psoriatic arthritis ( 26626624) Rheumatoid arthritis ( 30572963) Rheumatoid arthritis (ACPA-positive) ( 23143596) Serum alkaline phosphatase levels ( 33547301) Sjögren's syndrome ( 24097067) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 28714469 27399966 26606652 26502338 23273568 19838195 33272962 19838193) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 29293537 30572963 31672989 21750679) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655)
Interacting Genes		49 interacting genes: ANAPC11 ARAF ATN1 ATXN7 BAG4 BAG5 BAG6 CACNA1A CACNA1C CLPP CRYBA4 CYSRT1 DDIAS DSCR9 DYRK1A ERRFI1 FAM110A GFI1B HOXA1 HSD3B7 IGFBP6 KHDRBS1 KRTAP19-2 KRTAP21-2 KRTAP6-1 LCE1C LCE2C LCE3A LCE3D MEOX2 MKRN3 MSRB3 NLGN3 NOS3 NR4A3 NUFIP2 RAF1 RERE RIC8A SGTA SHANK3 SLPI SOCS6 TIMP3 TMEM132D TNIP1 TRAF2 TXNDC5 UBQLN2	88 interacting genes: ABHD17A ADH6 AP1M1 BYSL C8orf33 CCDC112 CCDC121 CCNG1 CDC23 CDC37 CDIP1 CDKN1A CFAP53 CYSRT1 DAZAP2 DPPA4 EFEMP1 EHHADH ELOA FAM161A FAM168A GABARAP GABARAPL1 GABARAPL2 GIT2 GTF2B GTF2H1 IKBKG KIFC3 KRTAP19-3 KRTAP19-5 KRTAP19-7 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP8-1 LENG8 LITAF MAGEB18 MAGEH1 MAP1LC3A MAP1LC3B MAP1LC3C MAP3K1 MAPK1 MAPK10 MCM10 MCRS1 MOB1B MOB3C MORF4L1 MORF4L2 NIFK NME7 NOD2 PIBF1 PNKP RABAC1 RALBP1 RARA RARG RBFOX1 RNF11 RNF8 RPL5 S100B SELPLG SHTN1 SNIP1 SPATA2 SUMO2 SYT6 TBK1 TCEA2 TCEANC TCEANC2 TNFAIP3 TNIP3 TTC39A TTF2 TXLNA TYRO3 UBC VPS33B WTAP ZBTB25 ZMAT2 ZNHIT1
Entrez ID		2202	10318
HPRD ID		03331	09216
Ensembl ID		ENSG00000115380	ENSG00000145901
Uniprot IDs		A0A0S2Z3V1 A0A0S2Z4F1 B2R6M6 Q12805	A0A0A0MRZ4 A8K4N4 B7Z8K2 Q15025
PDB IDs			7EAL 7EAO 7EB9 8YFK 8YFL 8YFM 8YFN 9D34
Enriched GO Terms of Interacting Partners?		Keratinization Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Epidermis Development Regulation Of Protein Catabolic Process Identical Protein Binding Regulation Of Proteolysis Negative Regulation Of Apoptotic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Protein Metabolic Process Positive Regulation Of Glutamate Receptor Signaling Pathway Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Negative Regulation Of Protein Catabolic Process Regulation Of Type B Pancreatic Cell Proliferation Regulation Of Glutamate Receptor Signaling Pathway Protein Binding High Voltage-gated Calcium Channel Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process	Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Ubiquitin Protein Ligase Binding Autophagosome Maturation Protein Binding Autophagosome Membrane Mitophagy Autophagy Of Mitochondrion Autophagosome Cellular Response To Starvation Cellular Response To Nutrient Levels Autophagosome Assembly Protein-containing Complex Disassembly Autophagosome Organization Response To Starvation Macroautophagy Intermediate Filament Cytoplasmic Side Of Late Endosome Membrane Response To Nutrient Levels Phospholipid Binding Nucleoplasm Organelle Assembly Positive Regulation Of DNA Repair GABA Receptor Binding Regulation Of Protein Modification Process Positive Regulation Of DNA Metabolic Process Cellular Response To Stress Nucleic Acid Metabolic Process Trachea Cartilage Development Autophagy Negative Regulation Of Canonical NF-kappaB Signal Transduction Face Development Glandular Epithelial Cell Development Regulation Of Canonical NF-kappaB Signal Transduction Vacuole Organization DNA-templated Transcription Intestinal Stem Cell Homeostasis Regulation Of Cellular Response To Stress Cytosol Protein Modification Process Negative Regulation Of Cartilage Development Nucleus Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity DNA Damage Response Regulation Of Protein Phosphorylation Ciliary Basal Body Beta-tubulin Binding
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