EFEMP1 and TXNDC5

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		EFEMP1	TXNDC5
Gene Name		EGF containing fibulin-like extracellular matrix protein 1	thioredoxin domain containing 5 (endoplasmic reticulum)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Extracellular Matrix Extracellular Vesicular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Lysosomal Lumen Extracellular Vesicular Exosome
	Molecular Function	Epidermal Growth Factor-activated Receptor Activity Epidermal Growth Factor Receptor Binding Calcium Ion Binding Protein Binding Growth Factor Activity	Protein Disulfide Isomerase Activity Protein Binding
	Biological Process	Regulation Of Transcription, DNA-templated Epidermal Growth Factor Receptor Signaling Pathway Visual Perception Peptidyl-tyrosine Phosphorylation Extracellular Matrix Organization Negative Regulation Of Chondrocyte Differentiation	Protein Folding Post-Golgi Vesicle-mediated Transport Response To Endoplasmic Reticulum Stress Negative Regulation Of Apoptotic Process Apoptotic Cell Clearance Cell Redox Homeostasis Membrane Organization
Pathways		Molecules associated with elastic fibres Elastic fibre formation	Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding Lysosome Vesicle Biogenesis
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis ( 19451621) Height ( 20881960 19396169 19893584 23563607 18391951 18391952 20397748 20189936)
Protein-Protein Interactions		17 interactors: ARAF ATN1 ATXN7 BAG6 CACNA1A GFI1B KHDRBS1 NOS3 RAF1 RERE RIC8A SGTA SOCS6 TIMP3 TNIP1 TRAF2 TXNDC5	21 interactors: ALS2CR12 APP BLZF1 EFEMP1 GMPPB KRT38 KRT40 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-12 KRTAP4-2 LHX4 MGAT5B NOTCH2NL SPRY2 TRIM23 TRIM42 TRIP6
Entrez ID		2202	81567
HPRD ID		03331	18249
Ensembl ID		ENSG00000115380	ENSG00000239264
Uniprot IDs		B2R6M6 Q12805	Q6EHZ3 Q8NBS9
PDB IDs			2DIZ 3UJ1 3UVT
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Metabolic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cell Death Regulation Of Protein Metabolic Process Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Regulation Of Cell Death Regulation Of Proteolysis Regulation Of Signaling Regulation Of Cellular Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Phosphorylation Negative Regulation Of Cellular Protein Metabolic Process Cellular Response To Stimulus Regulation Of Signal Transduction Negative Regulation Of Protein Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Lyase Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Cell Death Regulation Of Nitrogen Compound Metabolic Process Death Chromatin Modification Negative Regulation Of Signal Transduction Cell-cell Adhesion Involved In Gastrulation Cerebellar Molecular Layer Development Modulation By Symbiont Of Host I-kappaB Kinase/NF-kappaB Cascade Death-inducing Signaling Complex Assembly Cellular Metabolic Process Signal Transduction Regulation Of Cyclase Activity Negative Regulation Of Signaling Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Intracellular Signal Transduction Response To Stress Chromatin Organization Positive Regulation Of Peptidyl-serine Phosphorylation Vestibular Nucleus Development Smooth Muscle Hyperplasia Positive Regulation Of RNA Export From Nucleus Positive Regulation Of Cyclic Nucleotide Metabolic Process Negative Regulation Of Proteolysis Signaling Negative Regulation Of Catalytic Activity Negative Regulation Of Biosynthetic Process Negative Regulation Of Protein Processing
Tagcloud ?		aberrant aza chip dac deacetylase deoxycytidine depth downregulation fibulin gc h3 histone immunoprecipitation invasion k9 loci markedly metastasis methylation methyltransferase modification node paired rapidly reactivated silenced silencing trichostatin trimethylation	aspects bio blotting cytoskeleton differentially dimensional downregulated downregulation electrophoresis eleven elucidate expressions gastric gastritis gel matched mucosa neuropolypeptide oxidation pebp1 phosphatidylethanolamine preliminarily rt ten thioredoxin upregulated upregulation validated varioliform
Tagcloud (Difference) ?		aberrant aza chip dac deacetylase deoxycytidine depth fibulin gc h3 histone immunoprecipitation invasion k9 loci markedly metastasis methylation methyltransferase modification node paired rapidly reactivated silenced silencing trichostatin trimethylation	aspects bio blotting cytoskeleton differentially dimensional downregulated electrophoresis eleven elucidate expressions gastric gastritis gel matched mucosa neuropolypeptide oxidation pebp1 phosphatidylethanolamine preliminarily rt ten thioredoxin upregulated upregulation validated varioliform
Tagcloud (Intersection) ?		downregulation