EFEMP1 and ARAF

Number of citations of the paper that reports this interaction (PMID 12620389)
9

Data Source:
HPRD (two hybrid)

		EFEMP1	ARAF
Gene Name		EGF containing fibulin-like extracellular matrix protein 1	A-Raf proto-oncogene, serine/threonine kinase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Extracellular Matrix Extracellular Vesicular Exosome	Cellular_component
	Molecular Function	Epidermal Growth Factor-activated Receptor Activity Epidermal Growth Factor Receptor Binding Calcium Ion Binding Protein Binding Growth Factor Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity Receptor Signaling Protein Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	Regulation Of Transcription, DNA-templated Epidermal Growth Factor Receptor Signaling Pathway Visual Perception Peptidyl-tyrosine Phosphorylation Extracellular Matrix Organization Negative Regulation Of Chondrocyte Differentiation	Cellular Protein Modification Process Protein Phosphorylation Regulation Of TOR Signaling Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Peptidyl-serine Phosphorylation Intracellular Signal Transduction Negative Regulation Of Apoptotic Process
Pathways		Molecules associated with elastic fibres Elastic fibre formation
Drugs			Adenosine triphosphate
Diseases
GWAS		Amyotrophic lateral sclerosis ( 19451621) Height ( 20881960 19396169 19893584 23563607 18391951 18391952 20397748 20189936)
Protein-Protein Interactions		17 interactors: ARAF ATN1 ATXN7 BAG6 CACNA1A GFI1B KHDRBS1 NOS3 RAF1 RERE RIC8A SGTA SOCS6 TIMP3 TNIP1 TRAF2 TXNDC5	38 interactors: AGTRAP ASS1 BAD CHD6 COPS3 CPS1 CSNK2B DIDO1 E2F6 EFEMP1 GNA12 HRAS IRAK2 IRF7 KLHL12 KRAS MAP2K1 MAP2K2 MLH1 MYO18A NELFCD NUDT14 PBK PDGFRB PIK3R1 PKM PRPF6 RABGGTB RGS12 RRAS RRAS2 TEKT4P2 TESK1 TIMM44 TIRAP WNK1 YWHAG YWHAZ
Entrez ID		2202	369
HPRD ID		03331	02405
Ensembl ID		ENSG00000115380	ENSG00000078061
Uniprot IDs		B2R6M6 Q12805	B4DV85 P10398 Q96II5
PDB IDs			1WXM
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Metabolic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cell Death Regulation Of Protein Metabolic Process Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Regulation Of Cell Death Regulation Of Proteolysis Regulation Of Signaling Regulation Of Cellular Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Phosphorylation Negative Regulation Of Cellular Protein Metabolic Process Cellular Response To Stimulus Regulation Of Signal Transduction Negative Regulation Of Protein Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Lyase Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Cell Death Regulation Of Nitrogen Compound Metabolic Process Death Chromatin Modification Negative Regulation Of Signal Transduction Cell-cell Adhesion Involved In Gastrulation Cerebellar Molecular Layer Development Modulation By Symbiont Of Host I-kappaB Kinase/NF-kappaB Cascade Death-inducing Signaling Complex Assembly Cellular Metabolic Process Signal Transduction Regulation Of Cyclase Activity Negative Regulation Of Signaling Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Intracellular Signal Transduction Response To Stress Chromatin Organization Positive Regulation Of Peptidyl-serine Phosphorylation Vestibular Nucleus Development Smooth Muscle Hyperplasia Positive Regulation Of RNA Export From Nucleus Positive Regulation Of Cyclic Nucleotide Metabolic Process Negative Regulation Of Proteolysis Signaling Negative Regulation Of Catalytic Activity Negative Regulation Of Biosynthetic Process Negative Regulation Of Protein Processing	Intracellular Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Immune Response-regulating Signaling Pathway Cellular Response To Stimulus Regulation Of Phosphorylation Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Kinase Activity Cellular Response To Peptide Hormone Stimulus Innate Immune Response Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cell Motility Regulation Of Signal Transduction Cellular Response To Peptide Cellular Response To Organonitrogen Compound Immune Response Neurotrophin TRK Receptor Signaling Pathway Ras Protein Signal Transduction Neurotrophin Signaling Pathway Regulation Of Locomotion Fc-epsilon Receptor Signaling Pathway Regulation Of Cellular Component Movement Signaling Response To Hormone Regulation Of Signaling Cell Communication Toll-like Receptor 4 Signaling Pathway Fc Receptor Signaling Pathway Cellular Response To Hormone Stimulus Regulation Of Cell Migration Phosphorylation Response To Stimulus Regulation Of MAPK Cascade Response To Oleic Acid Intrinsic Apoptotic Signaling Pathway Response To Peptide Hormone Defense Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Immune Response Response To Peptide Positive Regulation Of Cell Motility Toll-like Receptor Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of Cellular Component Movement Positive Regulation Of MAP Kinase Activity Cellular Response To Insulin Stimulus
Tagcloud ?		aberrant aza chip dac deacetylase deoxycytidine depth downregulation fibulin gc h3 histone immunoprecipitation invasion k9 loci markedly metastasis methylation methyltransferase modification node paired rapidly reactivated silenced silencing trichostatin trimethylation	al augmentation braf craf1 die differentiated disruption dramatically drosophila elegans embryos enlarged establish failed finding gestation interacts mek membranes mid mutagenesis programmed ras signalling unlike unpublished vessels w
Tagcloud (Difference) ?		aberrant aza chip dac deacetylase deoxycytidine depth downregulation fibulin gc h3 histone immunoprecipitation invasion k9 loci markedly metastasis methylation methyltransferase modification node paired rapidly reactivated silenced silencing trichostatin trimethylation	al augmentation braf craf1 die differentiated disruption dramatically drosophila elegans embryos enlarged establish failed finding gestation interacts mek membranes mid mutagenesis programmed ras signalling unlike unpublished vessels w
Tagcloud (Intersection) ?