EFEMP1 and CACNA1C

Number of citations of the paper that reports this interaction (PubMedID 21653829)
54

Data Source:
BioGRID (two hybrid)

		EFEMP1	CACNA1C
Description		EGF-like fibulin extracellular matrix protein 1	calcium voltage-gated channel subunit alpha1 C
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Extracellular Exosome	Nucleoplasm Cytoplasm Plasma Membrane Voltage-gated Calcium Channel Complex Cilium Postsynaptic Density Membrane Z Disc T-tubule Dendrite Monoatomic Ion Channel Complex Sarcolemma Cell Projection Perikaryon Synapse Postsynaptic Membrane Postsynaptic Density Membrane L-type Voltage-gated Calcium Channel Complex
	Molecular Function	Epidermal Growth Factor Receptor Activity Epidermal Growth Factor Receptor Binding Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Growth Factor Activity	Monoatomic Ion Channel Activity Voltage-gated Calcium Channel Activity Calcium Channel Activity Protein Binding Calmodulin Binding High Voltage-gated Calcium Channel Activity Metal Ion Binding Alpha-actinin Binding Voltage-gated Calcium Channel Activity Involved In Cardiac Muscle Cell Action Potential Voltage-gated Calcium Channel Activity Involved In AV Node Cell Action Potential
	Biological Process	Regulation Of DNA-templated Transcription Epidermal Growth Factor Receptor Signaling Pathway Visual Perception Peptidyl-tyrosine Phosphorylation Negative Regulation Of Chondrocyte Differentiation Camera-type Eye Development Embryonic Eye Morphogenesis Post-embryonic Eye Morphogenesis	Immune System Development Monoatomic Ion Transport Calcium Ion Transport Muscle Contraction Positive Regulation Of Cytosolic Calcium Ion Concentration Heart Development Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Monoatomic Ion Transmembrane Transport Embryonic Forelimb Morphogenesis Camera-type Eye Development Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Muscle Contraction Transmembrane Transport Calcium Ion Transport Into Cytosol Cardiac Conduction Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Calcium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Membrane Depolarization During Cardiac Muscle Cell Action Potential Membrane Depolarization During AV Node Cell Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Heart Rate By Cardiac Conduction Calcium Ion Import Across Plasma Membrane Regulation Of Ventricular Cardiac Muscle Cell Action Potential Membrane Depolarization During Atrial Cardiac Muscle Cell Action Potential
Pathways		Molecules associated with elastic fibres Molecules associated with elastic fibres	Adrenaline,noradrenaline inhibits insulin secretion NCAM1 interactions Regulation of insulin secretion Regulation of insulin secretion Phase 0 - rapid depolarisation Phase 2 - plateau phase
Drugs			Ergocalciferol Enflurane Ranolazine Phenytoin Isradipine Topiramate Ibutilide Diltiazem Amlodipine Nimodipine Nisoldipine Spironolactone Cinnarizine Nicardipine Nicardipine Magnesium sulfate Verapamil Verapamil Levomenthol Ethanol Felodipine Nitrendipine Nitrendipine Miconazole Nifedipine Amiodarone Calcium Mibefradil Dronedarone Clevidipine Nilvadipine Nilvadipine Drotaverine Trimebutine Barnidipine Aranidipine Benidipine Cilnidipine Efonidipine Efonidipine Efonidipine Lacidipine Levamlodipine Manidipine Butamben Isavuconazole Propiverine Bioallethrin Bioallethrin Fish oil
Diseases		Familial flecked retina syndrome, including: Doyne honeycomb degeneration of retina (DHRD); Basal laminar drusen (BLD); Fundus albipunctatus (FA); Retinitis punctata albescens (RPA); Bietti crystalline corneoretinal dystrophy (BCD)	Brugada syndrome (BRS) Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
GWAS		A body shape index ( 34021172) Amyotrophic lateral sclerosis ( 19451621) Appendicular lean mass ( 33097823) Blood protein levels ( 30072576) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Carpal tunnel syndrome ( 30833571) Childhood ear infection ( 27182965 28928442) Chronic venous disease ( 28374850) Deep white matter hyperintensities ( 32517579) Diastolic blood pressure ( 30578418) Diverticular disease ( 30177863) FEV1 ( 30804560) Glaucoma (primary open-angle) ( 33627673) Height ( 18391952 31562340 28552196 33713608 34270706 25429064 18391951 19396169 19893584 20189936 20397748 20881960 23563607 25282103) Hip circumference adjusted for BMI ( 34021172 25673412) Inguinal hernia ( 26686553) Intraocular pressure ( 29235454 29617998 29785010 30054594) Joint mobility (Beighton score) ( 27182965) Lung function (FEV1/FVC) ( 30804560) Lung function (forced vital capacity) ( 24929828) Lung function (FVC) ( 30804560) Lung volume ( 34128465) Metabolite levels ( 23823483) Optic cup area ( 28073927 25631615) Pelvic organ prolapse ( 32184442) Pelvic organ prolapse (moderate/severe) ( 26545240) Periventricular white matter hyperintensities ( 32517579) Pulse pressure ( 27841878 30578418) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for BMI in smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 26785701 28552196 34021172 28448500) Waist-hip index ( 34021172) White matter hyperintensities ( 32358547) White matter hyperintensity burden ( 25663218) White matter hyperintensity volume ( 33293549 29752348 30659137) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549) Youthful appearance (self-reported) ( 32339537)	Acoustic startle blink response ( 25387708) Adult body size ( 32376654) Adventurousness ( 30643258) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Aortic root size ( 28394258) Appendicular lean mass ( 33097823) Atypical femoral fracture in phosphonate treatment ( 31006051) Autism spectrum disorder or schizophrenia ( 28540026) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Bipolar disorder ( 18711365 34002096 33263727 31043756 28072414 20351715) Bipolar disorder or major depressive disorder ( 20351715) Bipolar I disorder ( 31043756) Broad depression or bipolar disorder ( 30626913) Broad depression or schizophrenia ( 30626913) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Diastolic blood pressure ( 30224653) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Exploratory eye movement dysfunction in schizophrenia (cognitive search score) ( 26242244) Fractional exhaled nitric oxide (childhood) ( 24315451) General risk tolerance (MTAG) ( 30643258) Heel bone mineral density ( 28869591 30598549) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Lumbar spine bone mineral density (integral) ( 27476799) Lumbar spine bone mineral density (trabecular) ( 27476799) Major depressive disorder and major depressive episode treated with electroconvulsive therapy ( 33483693) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Perceived intensity of aspartame ( 31005972) Platelet count ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Post bronchodilator FEV1/FVC ratio ( 26634245) Psychosis proneness (hypomanic personality scale and revised physical anhedonia scale) ( 28525603) Psychosis proneness (hypomanic personality scale) ( 28525603) Red blood cell count ( 27863252 32888494 29403010) Red blood cell traits ( 23222517) Response to olanzapine in schizophrenia ( 29503163) Resting heart rate ( 27798624 29769521) Schizophrenia ( 23974872 25056061 28991256 29483656 21926974 22688191 30285260) Schizophrenia or bipolar disorder ( 24280982) Sensorimotor dexterity ( 31596458) Short-term memory (digit-span task) ( 30741946) Sleep quality ( 23728906) Warfarin maintenance dose ( 18535201)
Interacting Genes		49 interacting genes: ANAPC11 ARAF ATN1 ATXN7 BAG4 BAG5 BAG6 CACNA1A CACNA1C CLPP CRYBA4 CYSRT1 DDIAS DSCR9 DYRK1A ERRFI1 FAM110A GFI1B HOXA1 HSD3B7 IGFBP6 KHDRBS1 KRTAP19-2 KRTAP21-2 KRTAP6-1 LCE1C LCE2C LCE3A LCE3D MEOX2 MKRN3 MSRB3 NLGN3 NOS3 NR4A3 NUFIP2 RAF1 RERE RIC8A SGTA SHANK3 SLPI SOCS6 TIMP3 TMEM132D TNIP1 TRAF2 TXNDC5 UBQLN2	25 interacting genes: ACTN2 ANKRD35 BSG C18orf32 CABP1 CACNB3 COPS5 DNAJA3 EFEMP1 FHL2 GNB1 HDAC4 IFT88 NUP133 PCBD1 PICK1 PPM1A PRKACA RIC3 RIMS1 RYR2 SRI SRRT TNIP2 VCP
Entrez ID		2202	775
HPRD ID		03331	00246
Ensembl ID		ENSG00000115380	ENSG00000151067
Uniprot IDs		A0A0S2Z3V1 A0A0S2Z4F1 B2R6M6 Q12805	A0A0A0MR67 A0A0A0MSA1 A0A804HI37 A0A804HIJ8 A0A804HJB6 A0A804HKC4 E9PDI6 F5H522 Q13936 Q59GU3 Q5V9X9
PDB IDs			1T0J 2BE6 2F3Y 2F3Z 2LQC 3G43 3OXQ 5V2P 5V2Q 6C0A 6DAD 6DAE 6DAF 6U39 6U3A 6U3B 6U3D 7L8V 8EOG 8EOI 8FD7 8FHS 8HLP 8HMA 8HMB 8UKO 8UKP 8WE6 8WE7 8WE8 8WE9 8WEA
Enriched GO Terms of Interacting Partners?		Keratinization Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Epidermis Development Regulation Of Protein Catabolic Process Identical Protein Binding Regulation Of Proteolysis Negative Regulation Of Apoptotic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Protein Metabolic Process Positive Regulation Of Glutamate Receptor Signaling Pathway Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Negative Regulation Of Protein Catabolic Process Regulation Of Type B Pancreatic Cell Proliferation Regulation Of Glutamate Receptor Signaling Pathway Protein Binding High Voltage-gated Calcium Channel Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process	Synapse Intracellular Protein Localization Regulation Of Protein Localization Cellular Localization Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Channel Activator Activity Z Disc Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Protein Transport Calcium Channel Regulator Activity Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Transport Protein Localization To Membrane Cellular Response To Epinephrine Stimulus Regulation Of Establishment Of Protein Localization Calcium Ion Transport Into Cytosol Intracellular Protein Transport Regulation Of ATP Metabolic Process Response To Epinephrine Positive Regulation Of Transport Regulation Of Cardiac Muscle Contraction Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Purine Nucleotide Metabolic Process Response To Heat Regulation Of Biological Quality Protein Domain Specific Binding Positive Regulation Of Protein Export From Nucleus Negative Regulation Of Glycolytic Process Regulation Of Monoatomic Ion Transport Establishment Of Localization In Cell Cell Communication By Electrical Coupling Regulation Of Striated Muscle Contraction Cell Communication Involved In Cardiac Conduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Membrane Potential Regulation Of Heart Rate Regulation Of Post-translational Protein Modification Positive Regulation Of Cation Channel Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Cardiac Muscle Hypertrophy Negative Regulation Of ATP Metabolic Process Protein Kinase A Regulatory Subunit Binding Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cation Transmembrane Transport Regulation Of Intracellular Transport Regulation Of Protein Secretion Regulation Of Cardiac Conduction Calcium Channel Complex Muscle Hypertrophy
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?