EFEMP1 and SOCS6

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		EFEMP1	SOCS6
Gene Name		EGF containing fibulin-like extracellular matrix protein 1	suppressor of cytokine signaling 6
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Extracellular Matrix Extracellular Vesicular Exosome	Immunological Synapse Cytoplasm
	Molecular Function	Epidermal Growth Factor-activated Receptor Activity Epidermal Growth Factor Receptor Binding Calcium Ion Binding Protein Binding Growth Factor Activity	Protein Kinase Inhibitor Activity Protein Binding
	Biological Process	Regulation Of Transcription, DNA-templated Epidermal Growth Factor Receptor Signaling Pathway Visual Perception Peptidyl-tyrosine Phosphorylation Extracellular Matrix Organization Negative Regulation Of Chondrocyte Differentiation	Negative Regulation Of Protein Kinase Activity Defense Response JAK-STAT Cascade Proteasomal Protein Catabolic Process Protein Ubiquitination Cytokine-mediated Signaling Pathway Regulation Of Growth Negative Regulation Of JAK-STAT Cascade Negative Regulation Of T Cell Activation
Pathways		Molecules associated with elastic fibres Elastic fibre formation	Signaling by SCF-KIT Regulation of KIT signaling
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis ( 19451621) Height ( 20881960 19396169 19893584 23563607 18391951 18391952 20397748 20189936)	Systemic lupus erythematosus ( 18204098)
Protein-Protein Interactions		17 interactors: ARAF ATN1 ATXN7 BAG6 CACNA1A GFI1B KHDRBS1 NOS3 RAF1 RERE RIC8A SGTA SOCS6 TIMP3 TNIP1 TRAF2 TXNDC5	22 interactors: ACVR1 BMPR1B EFEMP1 INSR IRS2 IRS4 KDM1A KIT PIK3R1 PIK3R2 RBCK1 RELA SMURF2 TCEB1 TCEB2 TGFBR1 TUBA1A TUBB4B UBE2D2 UBE2I WDR89 ZMIZ2
Entrez ID		2202	9306
HPRD ID		03331	05491
Ensembl ID		ENSG00000115380	ENSG00000170677
Uniprot IDs		B2R6M6 Q12805	O14544
PDB IDs			2VIF
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Metabolic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cell Death Regulation Of Protein Metabolic Process Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Regulation Of Cell Death Regulation Of Proteolysis Regulation Of Signaling Regulation Of Cellular Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Phosphorylation Negative Regulation Of Cellular Protein Metabolic Process Cellular Response To Stimulus Regulation Of Signal Transduction Negative Regulation Of Protein Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Lyase Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Cell Death Regulation Of Nitrogen Compound Metabolic Process Death Chromatin Modification Negative Regulation Of Signal Transduction Cell-cell Adhesion Involved In Gastrulation Cerebellar Molecular Layer Development Modulation By Symbiont Of Host I-kappaB Kinase/NF-kappaB Cascade Death-inducing Signaling Complex Assembly Cellular Metabolic Process Signal Transduction Regulation Of Cyclase Activity Negative Regulation Of Signaling Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Intracellular Signal Transduction Response To Stress Chromatin Organization Positive Regulation Of Peptidyl-serine Phosphorylation Vestibular Nucleus Development Smooth Muscle Hyperplasia Positive Regulation Of RNA Export From Nucleus Positive Regulation Of Cyclic Nucleotide Metabolic Process Negative Regulation Of Proteolysis Signaling Negative Regulation Of Catalytic Activity Negative Regulation Of Biosynthetic Process Negative Regulation Of Protein Processing	Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Growth Factor Stimulus Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Response To Growth Factor Regulation Of RNA Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Protein Metabolic Process Cellular Response To Hormone Stimulus Regulation Of Signaling Positive Regulation Of Cellular Biosynthetic Process Regulation Of Metabolic Process Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Signal Transduction Immune Response-regulating Signaling Pathway Cellular Response To Organic Substance Response To Insulin Response To Stimulus Insulin Receptor Signaling Pathway Positive Regulation Of Gene Expression Cellular Response To Peptide Hormone Stimulus Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Cellular Response To Peptide Viral Process ERBB Signaling Pathway Cellular Protein Modification Process Cellular Response To Stimulus Negative Regulation Of Programmed Cell Death Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Metabolic Process Response To Hormone Response To Stress Defense Response Regulation Of Cartilage Development Negative Regulation Of Cell Death Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Tagcloud ?		aberrant aza chip dac deacetylase deoxycytidine depth downregulation fibulin gc h3 histone immunoprecipitation invasion k9 loci markedly metastasis methylation methyltransferase modification node paired rapidly reactivated silenced silencing trichostatin trimethylation	6r c3 castration cis constitutively crpc erk1 exogenous express gp130 il jak1 jak2 jak3 lncap ned neuroendocrine s17 secretes sh2 slightly socs1 socs7 stat3 subline sublines suppressors though tyk2
Tagcloud (Difference) ?		aberrant aza chip dac deacetylase deoxycytidine depth downregulation fibulin gc h3 histone immunoprecipitation invasion k9 loci markedly metastasis methylation methyltransferase modification node paired rapidly reactivated silenced silencing trichostatin trimethylation	6r c3 castration cis constitutively crpc erk1 exogenous express gp130 il jak1 jak2 jak3 lncap ned neuroendocrine s17 secretes sh2 slightly socs1 socs7 stat3 subline sublines suppressors though tyk2
Tagcloud (Intersection) ?