TIMP2 and MMP2

Number of citations of the paper that reports this interaction (PMID 12032297)
26

Data Source:
HPRD (two hybrid, in vitro)

		TIMP2	MMP2
Gene Name		TIMP metallopeptidase inhibitor 2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Basement Membrane Extracellular Space Cell Surface Growth Cone Neuronal Cell Body Extracellular Vesicular Exosome	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Nucleus Mitochondrion Plasma Membrane Sarcomere
	Molecular Function	Protease Binding Integrin Binding Protein Binding Enzyme Activator Activity Metalloendopeptidase Inhibitor Activity Metal Ion Binding	Metalloendopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Zinc Ion Binding
	Biological Process	Central Nervous System Development Aging Negative Regulation Of Cell Proliferation Response To Hormone Negative Regulation Of Endopeptidase Activity Extracellular Matrix Disassembly Extracellular Matrix Organization Regulation Of Rap Protein Signal Transduction Response To Cytokine Response To Drug Positive Regulation Of MAPK Cascade Positive Regulation Of Neuron Differentiation Positive Regulation Of Adenylate Cyclase Activity Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Metalloenzyme Activity Negative Regulation Of Membrane Protein Ectodomain Proteolysis Cellular Response To Organic Substance	Angiogenesis Response To Hypoxia Blood Vessel Maturation Intramembranous Ossification Proteolysis Axon Guidance Embryo Implantation Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Endodermal Cell Differentiation Cellular Protein Metabolic Process Positive Regulation Of Innate Immune Response Ephrin Receptor Signaling Pathway Face Morphogenesis Bone Trabecula Formation Cellular Response To Amino Acid Stimulus
Pathways		Activation of Matrix Metalloproteinases Degradation of the extracellular matrix	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) EPH-ephrin mediated repulsion of cells Axon guidance Collagen degradation Activation of Matrix Metalloproteinases EPH-Ephrin signaling Degradation of the extracellular matrix
Drugs			Marimastat Captopril SC-74020
Diseases
GWAS		Dupuytren's disease ( 21732829) Obesity-related traits ( 23251661)
Protein-Protein Interactions		5 interactors: ITGA3 ITGB1 MMP14 MMP2 MMP8	34 interactors: A2M ACAN BACE1 BCAN CCL7 CLDN1 COL18A1 COL1A1 COL6A3 COL7A1 CXCL12 DCN EPHB2 FGFR1 HAPLN1 HSP90AA1 IGFBP3 IL1B ITGAV KISS1 LCN2 LGALS3 MMP14 MMP17 MMP25 PZP SPOCK1 TGFB1 THBS1 THBS2 TIMP1 TIMP2 TIMP3 TIMP4
Entrez ID		7077	4313
HPRD ID		01784	00386
Ensembl ID		ENSG00000035862	ENSG00000087245
Uniprot IDs		P16035	P08253
PDB IDs		1BR9 1GXD 2TMP	1CK7 1CXW 1EAK 1GEN 1GXD 1HOV 1J7M 1KS0 1QIB 1RTG 3AYU
Enriched GO Terms of Interacting Partners?		Formation Of Primary Germ Layer Gastrulation Extracellular Matrix Organization Extracellular Structure Organization Embryonic Morphogenesis Endodermal Cell Differentiation Endoderm Formation Collagen Catabolic Process Anatomical Structure Formation Involved In Morphogenesis Embryo Development Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Endoderm Development Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Tissue Development Negative Regulation Of Rho Protein Signal Transduction Regulation Of Cell-substrate Adhesion Cardiovascular System Development Female Pregnancy Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Plasma Membrane Anatomical Structure Morphogenesis Mesodermal Cell Differentiation Response To Gonadotropin Positive Regulation Of Cell Migration Angiogenesis Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Regulation Of Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Locomotion Single Organism Reproductive Process Locomotion Reproductive Process Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Small GTPase Mediated Signal Transduction Blood Vessel Morphogenesis Cell Differentiation Movement Of Cell Or Subcellular Component Blood Vessel Development Maternal Process Involved In Female Pregnancy Vasculature Development Neurogenesis Mesoderm Formation Regulation Of Cell Migration Mesoderm Morphogenesis Regulation Of Cell Adhesion Regulation Of Cell Motility Tissue Morphogenesis	Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Protein Metabolic Process Regulation Of Peptidase Activity Regulation Of Cell Migration Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Motility Negative Regulation Of Proteolysis Negative Regulation Of Metalloenzyme Activity Negative Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Protein Processing Regulation Of Proteolysis Developmental Process Regulation Of Locomotion Regulation Of Endopeptidase Activity Regulation Of Cellular Component Movement Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Cell Adhesion Locomotion Positive Regulation Of Cell Migration Response To External Stimulus Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Anatomical Structure Development Regulation Of Catalytic Activity Movement Of Cell Or Subcellular Component Negative Regulation Of Catalytic Activity Regulation Of Protein Metabolic Process Cell Migration Negative Regulation Of Cell Adhesion Multicellular Organismal Development Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Cell Motility Collagen Catabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Locomotion Skeletal System Development System Development Collagen Metabolic Process Chemotaxis Cell Differentiation Multicellular Organismal Macromolecule Metabolic Process Regulation Of Cell Adhesion Multicellular Organismal Metabolic Process
Tagcloud ?		achn acquired analyze bo5 bone determinants elucidate elucidated enhancer ex explore ezh2 homolog immunohistochemical metalloproteinase metastasis metastasized methylated methylation mmp2 newly parental rcc specimens subline tissues underlying upregulation zeste	5microm actin anxa2 beside depend depends evoked fibroblasts fro h2o2 likewise metalloproteinase mitogenic mmps nsmase2 p38mapk peroxide pretreated remodeling reorganization ro28 sb203580 shape smc sphingolipid sphingomyelinase src triggered unable
Tagcloud (Difference) ?		achn acquired analyze bo5 bone determinants elucidate elucidated enhancer ex explore ezh2 homolog immunohistochemical metastasis metastasized methylated methylation newly parental rcc specimens subline tissues underlying upregulation zeste	5microm actin anxa2 beside depend depends evoked fibroblasts fro h2o2 likewise mitogenic mmps nsmase2 p38mapk peroxide pretreated remodeling reorganization ro28 sb203580 shape smc sphingolipid sphingomyelinase src triggered unable
Tagcloud (Intersection) ?		metalloproteinase mmp2