TIMP2 and MMP2

Number of citations of the paper that reports this interaction (PubMedID 12032297)
44

Data Source:
HPRD (two hybrid, in vitro)

		TIMP2	MMP2
Description		TIMP metallopeptidase inhibitor 2	matrix metallopeptidase 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Secretory Granule Lumen Specific Granule Lumen Tertiary Granule Lumen Ficolin-1-rich Granule Lumen	Extracellular Region Extracellular Space Nucleus Cytoplasm Mitochondrion Plasma Membrane Membrane Sarcomere Extracellular Matrix
	Molecular Function	Protease Binding Enzyme Inhibitor Activity Protein Binding Metalloendopeptidase Inhibitor Activity Zinc Ion Binding Peptidase Inhibitor Activity Metal Ion Binding Molecular Function Inhibitor Activity	Fibronectin Binding Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Response To Hormone Response To Cytokine Negative Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Metallopeptidase Activity	Angiogenesis Ovarian Follicle Development Ovulation From Ovarian Follicle Luteinization Response To Hypoxia Blood Vessel Maturation Intramembranous Ossification Proteolysis Response To Oxidative Stress Negative Regulation Of Cell Adhesion Heart Development Female Pregnancy Embryo Implantation Parturition Response To Xenobiotic Stimulus Response To Mechanical Stimulus Peripheral Nervous System Axon Regeneration Response To Activity Cell Migration Extracellular Matrix Disassembly Protein Catabolic Process Extracellular Matrix Organization Positive Regulation Of Cell Migration Collagen Catabolic Process Response To Retinoic Acid Response To Cytokine Cellular Response To Reactive Oxygen Species Response To Nicotine Endodermal Cell Differentiation Response To Hydrogen Peroxide Positive Regulation Of Apoptotic Process Response To Estrogen Negative Regulation Of Vasoconstriction Ephrin Receptor Signaling Pathway Macrophage Chemotaxis Positive Regulation Of Smooth Muscle Cell Proliferation Skeletal System Morphogenesis Tissue Remodeling Response To Electrical Stimulus Response To Hyperoxia Face Morphogenesis Bone Trabecula Formation Prostate Gland Epithelium Morphogenesis Trophoblast Cell Migration Cellular Response To Amino Acid Stimulus Cellular Response To Cytokine Stimulus Cellular Response To Interleukin-1 Cellular Response To Estradiol Stimulus Cellular Response To UV-A Cellular Response To Fluid Shear Stress Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Response To Amyloid-beta Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Pathways		Activation of Matrix Metalloproteinases Neutrophil degranulation TGFBR3 PTM regulation	Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) EPH-ephrin mediated repulsion of cells Interleukin-4 and Interleukin-13 signaling Extra-nuclear estrogen signaling
Drugs			Marimastat Captopril SC-74020 Halofuginone AE-941 Endostatin Oleandrin
Diseases			Choriocarcinoma Penile cancer Torg-Winchester syndrome
GWAS		Blood protein levels ( 30072576) Dupuytren's disease ( 21732829) Heel bone mineral density ( 30598549) Late-onset Alzheimer's disease ( 27770636) Obesity-related traits ( 23251661) Periodontitis (CDC/AAP) ( 24024966)	Heel bone mineral density ( 30598549) Lack of premeditation ( 30718321) Refractive error ( 32231278)
Interacting Genes		6 interacting genes: ITGA3 ITGB1 MMP14 MMP2 MMP8 UBQLN2	40 interacting genes: A2M ACAN BACE1 BCAN CAPN3 CCL7 CCN5 CLDN1 COL18A1 COL1A1 COL6A3 COL7A1 CXCL12 DCN EPHB2 FGFR1 HAPLN1 HSP90AA1 IGFBP3 IL1B ITGAV KISS1 LCN2 LGALS3 MMP14 MMP17 MMP25 MTDH MTNR1A MTNR1B PZP REL SPOCK1 TGFB1 THBS1 THBS2 TIMP1 TIMP2 TIMP3 TIMP4
Entrez ID		7077	4313
HPRD ID		01784	00386
Ensembl ID		ENSG00000035862	ENSG00000087245
Uniprot IDs		A0A140VK57 P16035	P08253
PDB IDs		1BR9 1GXD 2TMP 4ILW	1CK7 1CXW 1EAK 1GEN 1GXD 1HOV 1J7M 1KS0 1QIB 1RTG 3AYU 7XGJ 7XJO 8H78
Enriched GO Terms of Interacting Partners?		Fibronectin Binding Integrin Alpha3-beta1 Complex Endodermal Cell Differentiation Collagen Catabolic Process Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Collagen Metabolic Process Endopeptidase Activity Metalloendopeptidase Activity Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Vasoconstriction Metallopeptidase Activity Mesodermal Cell Differentiation Integrin Binding Serine-type Endopeptidase Activity Regulation Of Protein Localization To Cell Periphery Positive Regulation Of Cell Migration Laminin Binding Positive Regulation Of Cell Motility Regulation Of Protein Localization To Membrane Positive Regulation Of Locomotion Negative Regulation Of Rho Protein Signal Transduction Regulation Of Signal Transduction Integrin Complex Regulation Of Cell Communication Regulation Of Signaling Cell Migration Angiogenesis Ovarian Follicle Development Regulation Of Cell Migration Regulation Of Cell Motility Negative Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Locomotion Synaptic Membrane Cell Motility Regulation Of Vasoconstriction Response To Estrogen Positive Regulation Of Protein Localization To Plasma Membrane Cell Differentiation Extracellular Matrix Positive Regulation Of Protein Localization To Cell Periphery Focal Adhesion Neuromuscular Junction Myoblast Fate Specification Response To Activity Integrin Alpha7-beta1 Complex Peptidase Activity Proteolysis Cellular Response To Genistein	Extracellular Matrix Extracellular Space Extracellular Region Peptidase Inhibitor Activity Protease Binding Metalloendopeptidase Inhibitor Activity Regulation Of Cell Migration Positive Regulation Of Cell Migration Regulation Of Cell Motility Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Locomotion Negative Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Membrane Protein Ectodomain Proteolysis Cell Adhesion Positive Regulation Of Developmental Process Response To Cytokine Response To Peptide Positive Regulation Of Mononuclear Cell Migration Response To Hormone Skeletal System Development Regulation Of Apoptotic Process Endoplasmic Reticulum Lumen Response To Mechanical Stimulus Regulation Of Multicellular Organismal Process Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Adhesion Regulation Of Programmed Cell Death Cell Migration Extracellular Matrix Binding Regulation Of Mononuclear Cell Migration Integrin Binding Positive Regulation Of Leukocyte Migration Perineuronal Net Negative Regulation Of Multicellular Organismal Process Serine-type Endopeptidase Inhibitor Activity Extracellular Matrix Structural Constituent Conferring Tensile Strength Response To Carbohydrate Regulation Of Proteolysis Regulation Of Developmental Process Basement Membrane Regulation Of Cell Junction Assembly Regulation Of Anatomical Structure Morphogenesis Cell Motility Extracellular Matrix Structural Constituent Conferring Compression Resistance Developmental Process Golgi Lumen Response To Xenobiotic Stimulus Negative Regulation Of Metallopeptidase Activity Angiogenesis
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