TIMP2 and ITGA3

Number of citations of the paper that reports this interaction (PMID 12887919)
89

Data Source:
HPRD (in vivo)

		TIMP2	ITGA3
Gene Name		TIMP metallopeptidase inhibitor 2	integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Basement Membrane Extracellular Space Cell Surface Growth Cone Neuronal Cell Body Extracellular Vesicular Exosome	Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Basolateral Plasma Membrane Growth Cone Filopodium Membrane Integrin Alpha3-beta1 Complex Receptor Complex Perinuclear Region Of Cytoplasm Excitatory Synapse Extracellular Vesicular Exosome Invadopodium Membrane Cell Periphery Synaptic Membrane
	Molecular Function	Protease Binding Integrin Binding Protein Binding Enzyme Activator Activity Metalloendopeptidase Inhibitor Activity Metal Ion Binding	Glycoprotein Binding Fibronectin Binding Protease Binding Integrin Binding Protein Binding Collagen Binding Protein Domain Specific Binding Laminin Binding Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Central Nervous System Development Aging Negative Regulation Of Cell Proliferation Response To Hormone Negative Regulation Of Endopeptidase Activity Extracellular Matrix Disassembly Extracellular Matrix Organization Regulation Of Rap Protein Signal Transduction Response To Cytokine Response To Drug Positive Regulation Of MAPK Cascade Positive Regulation Of Neuron Differentiation Positive Regulation Of Adenylate Cyclase Activity Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Metalloenzyme Activity Negative Regulation Of Membrane Protein Ectodomain Proteolysis Cellular Response To Organic Substance	Neuron Migration Cell-matrix Adhesion Integrin-mediated Signaling Pathway Heart Development Blood Coagulation Memory Positive Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Neuron Projection Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Wnt Signaling Pathway Extracellular Matrix Organization Lung Development Regulation Of BMP Signaling Pathway Negative Regulation Of Cell Projection Organization Response To Gonadotropin Negative Regulation Of Rho Protein Signal Transduction Exploration Behavior Response To Drug Skin Development Mesodermal Cell Differentiation Leukocyte Migration Maternal Process Involved In Female Pregnancy Nephron Development Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Dendritic Spine Maintenance Renal Filtration
Pathways		Activation of Matrix Metalloproteinases Degradation of the extracellular matrix	Laminin interactions Integrin cell surface interactions Basigin interactions Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS		Dupuytren's disease ( 21732829) Obesity-related traits ( 23251661)
Protein-Protein Interactions		5 interactors: ITGA3 ITGB1 MMP14 MMP2 MMP8	15 interactors: ADAM9 BIN1 CALR CD151 CD82 CD9 FHL2 FN1 HPS5 HSPD1 ITGB1 LGALS8 RABIF TIMP2 TSPAN4
Entrez ID		7077	3675
HPRD ID		01784	05431
Ensembl ID		ENSG00000035862	ENSG00000005884
Uniprot IDs		P16035	P26006
PDB IDs		1BR9 1GXD 2TMP
Enriched GO Terms of Interacting Partners?		Formation Of Primary Germ Layer Gastrulation Extracellular Matrix Organization Extracellular Structure Organization Embryonic Morphogenesis Endodermal Cell Differentiation Endoderm Formation Collagen Catabolic Process Anatomical Structure Formation Involved In Morphogenesis Embryo Development Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Endoderm Development Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Tissue Development Negative Regulation Of Rho Protein Signal Transduction Regulation Of Cell-substrate Adhesion Cardiovascular System Development Female Pregnancy Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Plasma Membrane Anatomical Structure Morphogenesis Mesodermal Cell Differentiation Response To Gonadotropin Positive Regulation Of Cell Migration Angiogenesis Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Regulation Of Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Locomotion Single Organism Reproductive Process Locomotion Reproductive Process Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Small GTPase Mediated Signal Transduction Blood Vessel Morphogenesis Cell Differentiation Movement Of Cell Or Subcellular Component Blood Vessel Development Maternal Process Involved In Female Pregnancy Vasculature Development Neurogenesis Mesoderm Formation Regulation Of Cell Migration Mesoderm Morphogenesis Regulation Of Cell Adhesion Regulation Of Cell Motility Tissue Morphogenesis	Cell Activation Positive Regulation Of Cell Adhesion Extracellular Matrix Organization Extracellular Structure Organization Calcium-independent Cell-matrix Adhesion Cellular Component Assembly Cell Junction Assembly Leukocyte Activation Positive Regulation Of Cell Development Cell-cell Adhesion Mediated By Integrin Regulation Of Neuron Differentiation Positive Regulation Of Catalytic Activity System Development Regulation Of Cell Adhesion Extracellular Matrix Disassembly Cell Differentiation Positive Regulation Of Endocytosis Positive Regulation Of Metabolic Process Cell Adhesion Mediated By Integrin Muscle Cell Differentiation Cardiac Muscle Cell Differentiation Cell Adhesion Regulation Of Neurogenesis Multicellular Organismal Development Cardiocyte Differentiation Anatomical Structure Development Lymphocyte Activation Positive Regulation Of Neurogenesis Blood Coagulation Regulation Of Cell Development Positive Regulation Of Cell Differentiation Hemostasis Immune System Process B Cell Activation Cell-matrix Adhesion Response To Hormone Regulation Of Endocytosis Cardiac Muscle Tissue Development Muscle Structure Development Developmental Process Regulation Of Catalytic Activity Single Organismal Cell-cell Adhesion Neurogenesis Cell-substrate Adhesion Positive Regulation Of Hydrolase Activity Protein Maturation Striated Muscle Cell Differentiation Regulation Of Body Fluid Levels Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		achn acquired analyze bo5 bone determinants elucidate elucidated enhancer ex explore ezh2 homolog immunohistochemical metalloproteinase metastasis metastasized methylated methylation mmp2 newly parental rcc specimens subline tissues underlying upregulation zeste
Tagcloud (Difference) ?		achn acquired analyze bo5 bone determinants elucidate elucidated enhancer ex explore ezh2 homolog immunohistochemical metalloproteinase metastasis metastasized methylated methylation mmp2 newly parental rcc specimens subline tissues underlying upregulation zeste
Tagcloud (Intersection) ?