TIMP2 and MMP14

Number of citations of the paper that reports this interaction (PubMedID 39238192)
65

Data Source:
BioGRID (imaging technique)
HPRD (in vitro, in vivo)

		TIMP2	MMP14
Description		TIMP metallopeptidase inhibitor 2	matrix metallopeptidase 14
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Secretory Granule Lumen Specific Granule Lumen Tertiary Granule Lumen Ficolin-1-rich Granule Lumen	Extracellular Space Nucleus Cytoplasm Golgi Lumen Cytosol Plasma Membrane Focal Adhesion Membrane Extracellular Matrix Cytoplasmic Vesicle Melanosome Macropinosome Intermediate Filament Cytoskeleton
	Molecular Function	Protease Binding Enzyme Inhibitor Activity Protein Binding Metalloendopeptidase Inhibitor Activity Zinc Ion Binding Peptidase Inhibitor Activity Metal Ion Binding Molecular Function Inhibitor Activity	Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Integrin Binding Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding Metalloaminopeptidase Activity
	Biological Process	Response To Hormone Response To Cytokine Negative Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Metallopeptidase Activity	Skeletal System Development Ossification Angiogenesis Ovarian Follicle Development Response To Hypoxia Endothelial Cell Proliferation Endochondral Ossification Proteolysis Response To Oxidative Stress Male Gonad Development Response To Mechanical Stimulus Anatomical Structure Morphogenesis Response To Hormone Positive Regulation Of Myotube Differentiation Positive Regulation Of Protein Processing Cell Migration Protein Processing Extracellular Matrix Disassembly Protein Catabolic Process Extracellular Matrix Organization Positive Regulation Of Cell Growth Lung Development Positive Regulation Of Cell Migration Collagen Catabolic Process Zymogen Activation Endodermal Cell Differentiation Chondrocyte Proliferation Astrocyte Cell Migration Response To Estrogen Positive Regulation Of B Cell Differentiation Negative Regulation Of Notch Signaling Pathway Embryonic Cranial Skeleton Morphogenesis Branching Morphogenesis Of An Epithelial Tube Tissue Remodeling Cell Motility Negative Regulation Of Focal Adhesion Assembly Head Development Bone Development Cellular Response To Genistein Craniofacial Suture Morphogenesis GDF15-GFRAL Signaling Pathway Negative Regulation Of GDF15-GFRAL Signaling Pathway Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Macrophage Migration Response To Odorant
Pathways		Activation of Matrix Metalloproteinases Neutrophil degranulation TGFBR3 PTM regulation	Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases TGFBR3 PTM regulation High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs			Marimastat
Diseases
GWAS		Blood protein levels ( 30072576) Dupuytren's disease ( 21732829) Heel bone mineral density ( 30598549) Late-onset Alzheimer's disease ( 27770636) Obesity-related traits ( 23251661) Periodontitis (CDC/AAP) ( 24024966)	Appendicular lean mass ( 33097823) Cardiovascular death, myocardial infarction or stroke in response to clopidogrel treatment ( 32472697) Diastolic blood pressure ( 30224653) Dupuytren's disease ( 28886342) Heel bone mineral density ( 28869591 30598549) Prostate cancer ( 29892016) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		6 interacting genes: ITGA3 ITGB1 MMP14 MMP2 MMP8 UBQLN2	44 interacting genes: ACAN ACE2 ADI1 AQP6 BCAR1 C1QBP CAV1 CCL7 CCN2 CCN5 CLDN1 CORO1C CXCL8 EBP ELOVL4 F11R F12 FHL3 FURIN HSD17B13 ITGAV KASH5 KISS1 LRP1 LUM MMP13 MMP2 MMP3 MSMO1 PLLP RRAD SDC1 SLPI SPOCK1 SPOCK3 STOM TGM2 TIMP2 TIMP3 TIMP4 TMEM31 TNF TNFRSF21 ZUP1
Entrez ID		7077	4323
HPRD ID		01784	02856
Ensembl ID		ENSG00000035862	ENSG00000157227
Uniprot IDs		A0A140VK57 P16035	P50281
PDB IDs		1BR9 1GXD 2TMP 4ILW	1BQQ 1BUV 2MQS 3C7X 3MA2 3X23 4P3C 4P3D 4QXU 5H0U 6CLZ 6CM1
Enriched GO Terms of Interacting Partners?		Fibronectin Binding Integrin Alpha3-beta1 Complex Endodermal Cell Differentiation Collagen Catabolic Process Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Collagen Metabolic Process Endopeptidase Activity Metalloendopeptidase Activity Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Vasoconstriction Metallopeptidase Activity Mesodermal Cell Differentiation Integrin Binding Serine-type Endopeptidase Activity Regulation Of Protein Localization To Cell Periphery Positive Regulation Of Cell Migration Laminin Binding Positive Regulation Of Cell Motility Regulation Of Protein Localization To Membrane Positive Regulation Of Locomotion Negative Regulation Of Rho Protein Signal Transduction Regulation Of Signal Transduction Integrin Complex Regulation Of Cell Communication Regulation Of Signaling Cell Migration Angiogenesis Ovarian Follicle Development Regulation Of Cell Migration Regulation Of Cell Motility Negative Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Locomotion Synaptic Membrane Cell Motility Regulation Of Vasoconstriction Response To Estrogen Positive Regulation Of Protein Localization To Plasma Membrane Cell Differentiation Extracellular Matrix Positive Regulation Of Protein Localization To Cell Periphery Focal Adhesion Neuromuscular Junction Myoblast Fate Specification Response To Activity Integrin Alpha7-beta1 Complex Peptidase Activity Proteolysis Cellular Response To Genistein	Extracellular Matrix Extracellular Space Extracellular Region Metalloendopeptidase Inhibitor Activity Regulation Of Membrane Protein Ectodomain Proteolysis Enzyme Inhibitor Activity Regulation Of Entry Of Bacterium Into Host Cell Symbiont Entry Into Host Cell Response To Amyloid-beta Negative Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Cell Motility Regulation Of Locomotion Biological Process Involved In Interaction With Host Extracellular Matrix Organization Extracellular Structure Organization Collagen Catabolic Process Endopeptidase Activity Regulation Of Cell Migration Regulation Of Cell Adhesion Regulation Of Proteolysis Regulation Of Transcytosis Extracellular Matrix Disassembly Peptidase Inhibitor Activity Positive Regulation Of Cell Migration Cell Migration Positive Regulation Of Cell Motility Endocytosis Membrane Raft Positive Regulation Of Locomotion Collagen Binding Collagen Metabolic Process Regulation Of Viral Process Leukocyte Migration Regulation Of Bicellular Tight Junction Assembly Apoptotic Cell Clearance Negative Regulation Of Proteolysis Viral Translation Viral Life Cycle Regulation Of Protein Catabolic Process Serine-type Endopeptidase Activity Regulation Of Multicellular Organismal Process Humoral Immune Response Heparin Binding Cell Motility Regulation Of Cell Junction Assembly Virus Receptor Activity Extracellular Matrix Binding Response To Cytokine Response To Peptide Receptor-mediated Endocytosis
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