SLC7A9

Description		solute carrier family 7 member 9
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GO Annotations	Cellular Component	Plasma Membrane Membrane Apical Plasma Membrane Brush Border Membrane
	Molecular Function	Protein Binding Amino Acid Transmembrane Transporter Activity Neutral L-amino Acid Transmembrane Transporter Activity L-cystine Transmembrane Transporter Activity Antiporter Activity Transmembrane Transporter Activity Peptide Antigen Binding Protein Heterodimerization Activity Broad Specificity Neutral L-amino Acid:basic L-amino Acid Antiporter Activity
	Biological Process	Amino Acid Transmembrane Transport Amino Acid Transport Neutral Amino Acid Transport L-cystine Transport Transmembrane Transport Protein-containing Complex Assembly L-alpha-amino Acid Transmembrane Transport Basic Amino Acid Transmembrane Transport
Pathways		Basigin interactions Amino acid transport across the plasma membrane Defective SLC3A1 causes cystinuria (CSNU) Defective SLC7A9 causes cystinuria (CSNU)
Drugs
Diseases		Cystinuria
GWAS		Chronic kidney disease ( 20383146) Creatinine levels ( 20383145 29403010 31015462) Estimated glomerular filtration rate ( 31015462 30604766) Fractional excretion of metabolites in chronic kidney disease ( 29545352) Glomerular filtration rate (creatinine) ( 26831199 28452372) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) L1-L4 bone mineral density x serum urate levels interaction ( 34046847) Serum metabolite levels ( 33031748) Urate levels ( 31578528) Urinary metabolite levels in chronic kidney disease ( 29545352 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995) Urinary metabolite ratios in chronic kidney disease ( 29545352) Urinary metabolites ( 21572414) Urinary metabolites (H-NMR features) ( 24586186)
Novel Interacting Genes		1 novel interacting genes: PUM3
Interacting Genes		3 interacting genes: CREB3 HSPB1 TGM2
Entrez ID		11136
HPRD ID		04997
Ensembl ID		ENSG00000021488
Uniprot IDs		P82251
PDB IDs		6LI9 6LID 6YUP 6YV1
Enriched GO Terms of Interacting Partners?		Response To Unfolded Protein Negative Regulation Of Protein Kinase C Signaling Peptide Dopaminyltransferase Activity Histone Serotonyltransferase Activity Peptide Histaminyltransferase Activity Protein-glutamine Glutaminase Activity Regulation Of Catalytic Activity Peptide Noradrenalinyltransferase Activity Peptide Serotonyltransferase Activity Histone Dopaminyltransferase Activity Positive Regulation Of Deacetylase Activity Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Chemotaxis Protein Deamination Positive Regulation Of Vasculature Development Positive Regulation Of Angiogenesis Protein Kinase C Inhibitor Activity Regulation Of Intrinsic Apoptotic Signaling Pathway Cellular Response To Serotonin Regulation Of Chemotaxis Regulation Of Protein Kinase C Signaling Negative Regulation Of Apoptotic Signaling Pathway Salivary Gland Cavitation Release From Viral Latency Dopamine Secretion Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Regulation Of Protein ADP-ribosylation CCR1 Chemokine Receptor Binding Cellular Response To Dopamine Positive Regulation Of Mitochondrial Calcium Ion Concentration Protein-glutamine Gamma-glutamyltransferase Activity Regulation Of Vasculature Development Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Angiogenesis Anterograde Axonal Protein Transport Positive Regulation Of Catalytic Activity Regulation Of Apoptotic Cell Clearance Cellular Response To Cocaine Response To Dopamine Catecholamine Secretion CAMP Response Element Binding Protein Binding Endoplasmic Reticulum Branching Involved In Salivary Gland Morphogenesis Regulation Of Apoptotic Signaling Pathway Protein Transport Along Microtubule Contractile Muscle Fiber Positive Regulation Of Endothelial Cell Chemotaxis Regulation Of Translation Focal Adhesion
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