DYNLT4 and ACVR2A

Number of citations: 0 (PubMedID 16982625)
Data Source: HPRD (two hybrid)

		DYNLT4	ACVR2A
Name		dynein light chain Tctex-type 4	activin A receptor type 2A
Structure		No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Nucleus Nucleolus Cytoplasm Microtubule Organizing Center Cytoskeleton Cytoplasmic Dynein Complex Cilium Axoneme Cytoplasmic Vesicle Motile Cilium Sperm Flagellum Cell Projection	Cytoplasm Plasma Membrane Cell Surface Membrane Inhibin-betaglycan-ActRII Complex Receptor Complex Activin Receptor Complex
	Molecular Function	Protein Binding Protein Phosphatase 1 Binding Dynein Intermediate Chain Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Coreceptor Activity Kinase Activity Activin Receptor Activity, Type I Activin Receptor Activity, Type II Transferase Activity Activin Receptor Activity Growth Factor Binding PDZ Domain Binding Inhibin Binding Identical Protein Binding Metal Ion Binding Activin Binding BMP Receptor Activity
	Biological Process	Microtubule-based Movement	Osteoblast Differentiation Gastrulation With Mouth Forming Second Positive Regulation Of Protein Phosphorylation Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Spermatogenesis Determination Of Left/right Symmetry Pattern Specification Process Mesoderm Development Male Gonad Development Anterior/posterior Pattern Specification Regulation Of Signal Transduction Negative Regulation Of Ossification Positive Regulation Of Bone Mineralization BMP Signaling Pathway Developmental Process Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Odontogenesis Of Dentin-containing Tooth Sperm Ejaculation Penile Erection Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Embryonic Skeletal System Development Sertoli Cell Proliferation Positive Regulation Of SMAD Protein Signal Transduction Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus
Pathways		None	Signaling by NODAL Regulation of signaling by NODAL Signaling by Activin Signaling by Activin Signaling by BMP TGFBR3 regulates activin signaling
Drugs		None	Sotatercept
GWAS		No GWAS studies recorded	Adult body size ( 32376654 ) Adventurousness ( 30643258 ) Arterial stiffness index ( 31235810 ) Asthma (adult onset) ( 31036433 ) Basophil count ( 32888494 ) Basophil percentage of granulocytes ( 27863252 ) Basophil percentage of white cells ( 27863252 ) Cerebrospinal T-tau levels ( 28247064 ) Diastolic blood pressure ( 30224653 ) Eosinophil count ( 32888494 ) Estimated glomerular filtration rate ( 31015462 ) Feeling hurt ( 29500382 ) Feeling miserable ( 29500382 ) Feeling nervous ( 29500382 ) Feeling tense ( 29500382 ) General risk tolerance (MTAG) ( 30643258 ) Glomerular filtration rate (creatinine) ( 26831199 ) Haemorrhoidal disease ( 33888516 ) HDL cholesterol levels ( 32203549 ) High myopia ( 31816047 ) Loneliness (MTAG) ( 29970889 ) Neutrophil percentage of granulocytes ( 27863252 ) Photic sneeze reflex ( 30899065 ) Refractive error ( 32231278 ) Response to statin therapy ( 20339536 ) Retinal detachment or retinal break ( 31816047 ) Urate levels ( 31985003 23263486 ) White blood cell count (basophil) ( 27863252 )
Interacting Genes		7 interacting genes: ACVR2A ENG MDFI PPP1CA PPP1CC TGFBR2 TGFBR3	23 interacting genes: ACVRL1 BMP10 BMP2 BMP4 BMP6 BMP7 CRIPTO DAXX DYNLT4 ENG ERBIN GDF2 GDF5 GDF9 IGSF1 INHBA INHBB INHBC MAGI2 NODAL PRSS50 SYNJ2BP TGFBR3
Entrez ID		343521	92
HPRD ID		15762	00025
Ensembl ID		ENSG00000188396	ENSG00000121989
Uniprot IDs		Q5JR98	P27037
PDB IDs		Not available	3Q4T 3SOC 4ASX 5NH3 7U5P
GO Terms Enriched among Interactors		Activin Binding Positive Regulation Of SMAD Protein Signal Transduction Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Binding Glycosaminoglycan Binding Inhibin-betaglycan-ActRII Complex Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Receptor Complex Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Coreceptor Activity Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Vasculogenesis Activin Receptor Complex Activin Receptor Activity, Type I Cardiac Septum Morphogenesis PTW/PP1 Phosphatase Complex Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Activity BMP Signaling Pathway Epithelial To Mesenchymal Transition Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Type II Transforming Growth Factor Beta Receptor Binding Anatomical Structure Morphogenesis Type I Transforming Growth Factor Beta Receptor Binding Transforming Growth Factor Beta Receptor Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Activity Mesenchymal Cell Differentiation Secondary Palate Development Tissue Morphogenesis Branching Morphogenesis Of An Epithelial Tube Embryonic Morphogenesis Endocardial Cushion Morphogenesis Morphogenesis Of A Branching Epithelium Heart Trabecula Morphogenesis BMP Binding Morphogenesis Of A Branching Structure Entrainment Of Circadian Clock By Photoperiod Animal Organ Morphogenesis Aorta Morphogenesis Protein Phosphatase 1 Binding Outflow Tract Septum Morphogenesis Negative Regulation Of SMAD Protein Signal Transduction Cardiac Epithelial To Mesenchymal Transition Photoperiodism Entrainment Of Circadian Clock Activin Receptor Signaling Pathway Cardiac Ventricle Morphogenesis Branching Involved In Blood Vessel Morphogenesis	Positive Regulation Of SMAD Protein Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of SMAD Protein Signal Transduction Growth Factor Activity Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway Cytokine Activity Activin Receptor Signaling Pathway Positive Regulation Of Cartilage Development Cell Surface Receptor Signaling Pathway Cellular Response To BMP Stimulus Regulation Of Cartilage Development Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Heart Development Extracellular Space Cellular Response To Growth Factor Stimulus Signal Transduction Response To Growth Factor Positive Regulation Of Epithelial Cell Differentiation Regulation Of Intracellular Signal Transduction Cardiac Epithelial To Mesenchymal Transition Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Animal Organ Development Positive Regulation Of Intracellular Signal Transduction Regulation Of Multicellular Organismal Development Negative Regulation Of Locomotion Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Epithelial Cell Proliferation Regulation Of Epithelial Cell Proliferation Regulation Of Signal Transduction Regulation Of Cell Migration Epithelial To Mesenchymal Transition Regulation Of Epithelial Cell Differentiation BMP Receptor Binding Positive Regulation Of BMP Signaling Pathway Tissue Morphogenesis Enzyme Activator Complex Regulation Of Cell Motility Positive Regulation Of Signal Transduction Positive Regulation Of Endothelial Cell Differentiation Regulation Of Locomotion Transforming Growth Factor Beta Receptor Signaling Pathway Cartilage Development Mesenchymal Cell Differentiation