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TCTEX1D4 and ACVR2A
Number of citations of the paper that reports this interaction (PMID
16982625
)
11
Data Source:
HPRD
(two hybrid)
TCTEX1D4
ACVR2A
Gene Name
Tctex1 domain containing 4
activin A receptor, type IIA
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Acrosomal Vesicle
Nucleus
Microtubule Organizing Center
Axoneme
Sperm Flagellum
Cytoplasm
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Surface
Inhibin-betaglycan-ActRII Complex
Receptor Complex
Molecular Function
Protein Binding
Protein Serine/threonine Kinase Activity
Transmembrane Receptor Protein Serine/threonine Kinase Activity
Receptor Signaling Protein Serine/threonine Kinase Activity
Transforming Growth Factor Beta-activated Receptor Activity
Protein Binding
ATP Binding
Coreceptor Activity
Activin-activated Receptor Activity
Growth Factor Binding
PDZ Domain Binding
Inhibin Binding
Protein Self-association
Metal Ion Binding
Activin Binding
Biological Process
Gastrulation With Mouth Forming Second
Positive Regulation Of Protein Phosphorylation
Protein Phosphorylation
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Spermatogenesis
Determination Of Left/right Symmetry
Mesoderm Development
Anterior/posterior Pattern Specification
Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Signal Transduction By Phosphorylation
Positive Regulation Of Bone Mineralization
BMP Signaling Pathway
Regulation Of BMP Signaling Pathway
Activin Receptor Signaling Pathway
Positive Regulation Of Activin Receptor Signaling Pathway
Sperm Ejaculation
Penile Erection
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of Osteoblast Differentiation
Embryonic Skeletal System Development
Regulation Of Nitric-oxide Synthase Activity
Sertoli Cell Proliferation
Cellular Response To BMP Stimulus
Pathways
Signaling by Activin
Regulation of signaling by NODAL
Signaling by BMP
Signaling by NODAL
Drugs
Diseases
GWAS
Response to statin therapy (
20339536
)
Urate levels (
23263486
)
Protein-Protein Interactions
6 interactors:
ACVR2A
ENG
PPP1CA
PPP1CC
TGFBR2
TGFBR3
17 interactors:
ACVRL1
BMP10
BMP6
BMP7
ENG
ERBB2IP
GDF2
GDF5
GDF9
IGSF1
INHBA
INHBB
INHBC
MAGI2
SYNJ2BP
TCTEX1D4
TGFBR3
Entrez ID
343521
92
HPRD ID
15762
00025
Ensembl ID
ENSG00000188396
ENSG00000121989
Uniprot IDs
Q5JR98
B4DWQ2
P27037
PDB IDs
3Q4T
3SOC
4ASX
Enriched GO Terms of Interacting Partners
?
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Cellular Response To Growth Factor Stimulus
Cellular Response To Transforming Growth Factor Beta Stimulus
Response To Transforming Growth Factor Beta
Cellular Response To Growth Factor Stimulus
Response To Growth Factor
Enzyme Linked Receptor Protein Signaling Pathway
Cellular Response To Organic Substance
BMP Signaling Pathway
Negative Regulation Of Signal Transduction
Response To Abiotic Stimulus
Response To Organic Substance
Negative Regulation Of Signaling
Regulation Of Signal Transduction
Phosphate-containing Compound Metabolic Process
Pathway-restricted SMAD Protein Phosphorylation
Regulation Of Signaling
Cell Surface Receptor Signaling Pathway
Cellular Protein Modification Process
Tissue Morphogenesis
Triglyceride Catabolic Process
Tissue Development
Branching Morphogenesis Of An Epithelial Tube
Entrainment Of Circadian Clock By Photoperiod
Photoperiodism
Entrainment Of Circadian Clock
Acylglycerol Catabolic Process
Morphogenesis Of A Branching Epithelium
Morphogenesis Of A Branching Structure
Regulation Of Nitric-oxide Synthase Activity
Cellular Protein Metabolic Process
Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Patterning Of Blood Vessels
Anatomical Structure Morphogenesis
Embryo Development
Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Epithelial Tube Morphogenesis
Regulation Of Gene Expression
Glycogen Metabolic Process
Positive Regulation Of Signal Transduction
Tube Morphogenesis
Signal Transduction
Protein Phosphorylation
Organ Regeneration
Regulation Of Oxidoreductase Activity
Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
SMAD Protein Signal Transduction
BMP Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Growth
Positive Regulation Of Signal Transduction
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Phosphorylation
Positive Regulation Of Protein Modification Process
Regulation Of Phosphorus Metabolic Process
Regulation Of Protein Phosphorylation
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of Signal Transduction
Activin Receptor Signaling Pathway
Positive Regulation Of Protein Metabolic Process
Regulation Of Signaling
Regulation Of Phosphorylation
Cell Surface Receptor Signaling Pathway
Regulation Of MAPK Cascade
Cell Development
Positive Regulation Of Cellular Metabolic Process
Regulation Of Cell Proliferation
Signal Transduction
Negative Regulation Of Cell Migration
Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Cell Motility
Cell Differentiation
Negative Regulation Of Cell Proliferation
Positive Regulation Of Metabolic Process
Negative Regulation Of Cellular Component Movement
Signaling
Cell Communication
Negative Regulation Of Locomotion
Regulation Of Protein Metabolic Process
Negative Regulation Of Epithelial Cell Proliferation
Tissue Development
Regulation Of Epithelial Cell Proliferation
Negative Regulation Of Epithelial Cell Migration
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Cell Differentiation
Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Cell Growth
Cellular Response To Growth Factor Stimulus
Cellular Response To Organic Substance
Response To Organic Substance
Cellular Response To Stimulus
Response To Growth Factor
Tagcloud
?
5p
alters
applying
bmp
bmp1a
cleaves
cluster
copyright
dies1
furin
impairs
interferes
mapk3
micrornas
mineralization
mir
osteoblast
osteoblasts
protected
reprogramming
reserved
rights
ski
smad
smad5
smurf1
systematically
tgfbr3
zfp423
Tagcloud (Difference)
?
5p
alters
applying
bmp
bmp1a
cleaves
cluster
copyright
dies1
furin
impairs
interferes
mapk3
micrornas
mineralization
mir
osteoblast
osteoblasts
protected
reprogramming
reserved
rights
ski
smad
smad5
smurf1
systematically
tgfbr3
zfp423
Tagcloud (Intersection)
?