DYNLT4 and ENG

Number of citations: 0 (PubMedID 16982625)
Data Source: HPRD (two hybrid, in vivo)

		DYNLT4	ENG
Name		dynein light chain Tctex-type 4	endoglin
Structure		No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Nucleus Nucleolus Cytoplasm Microtubule Organizing Center Cytoskeleton Cytoplasmic Dynein Complex Cilium Axoneme Cytoplasmic Vesicle Motile Cilium Sperm Flagellum Cell Projection	Extracellular Space Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Membrane Nuclear Body Receptor Complex Endothelial Microparticle
	Molecular Function	Protein Binding Protein Phosphatase 1 Binding Dynein Intermediate Chain Binding	Transmembrane Signaling Receptor Activity Type II Transforming Growth Factor Beta Receptor Binding Protein Binding Galactose Binding Glycosaminoglycan Binding Coreceptor Activity Signaling Receptor Activator Activity Type I Transforming Growth Factor Beta Receptor Binding BMP Binding Identical Protein Binding Protein Homodimerization Activity Activin Binding Transforming Growth Factor Beta Binding
	Biological Process	Microtubule-based Movement	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Branching Involved In Blood Vessel Morphogenesis Vasculogenesis Response To Hypoxia Negative Regulation Of Endothelial Cell Proliferation Heart Looping Sprouting Angiogenesis Positive Regulation Of Systemic Arterial Blood Pressure Outflow Tract Septum Morphogenesis Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Endocardial Cushion Morphogenesis Cardiac Ventricle Morphogenesis Cardiac Atrium Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Cell Migration Involved In Endocardial Cushion Formation Regulation Of DNA-templated Transcription Cell Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Heart Development Negative Regulation Of Gene Expression Regulation Of Cardiac Muscle Cell Apoptotic Process Cell Migration Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Central Nervous System Vasculogenesis Extracellular Matrix Disassembly Regulation Of Cell Adhesion Negative Regulation Of Cell Migration BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of BMP Signaling Pathway Dorsal Aorta Morphogenesis Wound Healing Regulation Of Cell Population Proliferation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Smooth Muscle Tissue Development Artery Morphogenesis Venous Blood Vessel Morphogenesis Cell Motility Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Atrial Cardiac Muscle Tissue Morphogenesis Cell Chemotaxis Positive Regulation Of SMAD Protein Signal Transduction Negative Regulation Of SMAD Protein Signal Transduction Detection Of Hypoxia Endocardial Cushion To Mesenchymal Transition Vascular Associated Smooth Muscle Cell Development Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Atrioventricular Canal Morphogenesis Regulation Of Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Regulation Of Cell Proliferation Involved In Heart Morphogenesis
Drugs		None	Carotuximab
Diseases		None	Hereditary hemorrhagic telangiectasia (HHT)
GWAS		No GWAS studies recorded	Blood protein levels ( 30072576 ) Body mass index ( 26426971 ) Metabolic syndrome ( 20694148 ) Monocyte count ( 32888494 )
Interacting Genes		7 interacting genes: ACVR2A ENG MDFI PPP1CA PPP1CC TGFBR2 TGFBR3	13 interacting genes: ACVR1 ACVR2A BMP2 BMP7 DYNLT4 GDF2 INHBA TGFB1 TGFB2 TGFB3 TGFBR1 TGFBR2 TGFBR3
Entrez ID		343521	2022
HPRD ID		15762	00565
Ensembl ID		ENSG00000188396	ENSG00000106991
Uniprot IDs		Q5JR98	B7Z6Y5 F5GX88 P17813 Q5T9B9 Q96CG0
PDB IDs		Not available	5HZV 5HZW 5I04
GO Terms Enriched among Interactors		Activin Binding Positive Regulation Of SMAD Protein Signal Transduction Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Binding Glycosaminoglycan Binding Inhibin-betaglycan-ActRII Complex Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Receptor Complex Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Coreceptor Activity Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Vasculogenesis Activin Receptor Complex Activin Receptor Activity, Type I Cardiac Septum Morphogenesis PTW/PP1 Phosphatase Complex Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Activity BMP Signaling Pathway Epithelial To Mesenchymal Transition Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Type II Transforming Growth Factor Beta Receptor Binding Anatomical Structure Morphogenesis Type I Transforming Growth Factor Beta Receptor Binding Transforming Growth Factor Beta Receptor Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Activity Mesenchymal Cell Differentiation Secondary Palate Development Tissue Morphogenesis Branching Morphogenesis Of An Epithelial Tube Embryonic Morphogenesis Endocardial Cushion Morphogenesis Morphogenesis Of A Branching Epithelium Heart Trabecula Morphogenesis BMP Binding Morphogenesis Of A Branching Structure Entrainment Of Circadian Clock By Photoperiod Animal Organ Morphogenesis Aorta Morphogenesis Protein Phosphatase 1 Binding Outflow Tract Septum Morphogenesis Negative Regulation Of SMAD Protein Signal Transduction Cardiac Epithelial To Mesenchymal Transition Photoperiodism Entrainment Of Circadian Clock Activin Receptor Signaling Pathway Cardiac Ventricle Morphogenesis Branching Involved In Blood Vessel Morphogenesis	Positive Regulation Of SMAD Protein Signal Transduction Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Response To Growth Factor Stimulus Positive Regulation Of Epithelial To Mesenchymal Transition Response To Growth Factor Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Animal Organ Development Type II Transforming Growth Factor Beta Receptor Binding Activin Receptor Signaling Pathway Activin Binding Type III Transforming Growth Factor Beta Receptor Binding Epithelial To Mesenchymal Transition Odontogenesis Transforming Growth Factor Beta Receptor Signaling Pathway Mesenchymal Cell Differentiation Animal Organ Morphogenesis Transforming Growth Factor Beta Binding Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Intracellular Signal Transduction Activin Receptor Complex Activin Receptor Activity, Type I Positive Regulation Of Cell Differentiation Tissue Morphogenesis Heart Development Cardiac Septum Morphogenesis Gland Morphogenesis Growth Factor Activity Cellular Response To BMP Stimulus Positive Regulation Of Developmental Process Roof Of Mouth Development Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition BMP Signaling Pathway Tube Morphogenesis Salivary Gland Morphogenesis Regulation Of Multicellular Organismal Development Anatomical Structure Morphogenesis Ventricular Septum Morphogenesis Transmembrane Receptor Protein Serine/threonine Kinase Activity Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Secondary Palate Development Regulation Of Cell Differentiation Cytokine Activity Positive Regulation Of Signal Transduction