DYNLT4 and TGFBR3

Number of citations: 0 (PubMedID 16982625)
Data Source: HPRD (two hybrid)

		DYNLT4	TGFBR3
Name		dynein light chain Tctex-type 4	transforming growth factor beta receptor 3
Structure		No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Nucleus Nucleolus Cytoplasm Microtubule Organizing Center Cytoskeleton Cytoplasmic Dynein Complex Cilium Axoneme Cytoplasmic Vesicle Motile Cilium Sperm Flagellum Cell Projection	Extracellular Region Extracellular Space Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Inhibin-betaglycan-ActRII Complex Receptor Complex Extracellular Exosome Cell Periphery
	Molecular Function	Protein Binding Protein Phosphatase 1 Binding Dynein Intermediate Chain Binding	Transmembrane Signaling Receptor Activity Transforming Growth Factor Beta Receptor Activity Type II Transforming Growth Factor Beta Receptor Binding Transforming Growth Factor Beta Receptor Binding Protein Binding Glycosaminoglycan Binding Heparin Binding Coreceptor Activity Fibroblast Growth Factor Binding PDZ Domain Binding BMP Binding SMAD Binding Activin Binding Transforming Growth Factor Beta Binding Transforming Growth Factor Beta Receptor Activity, Type III
	Biological Process	Microtubule-based Movement	Response To Hypoxia Epithelial To Mesenchymal Transition Liver Development Heart Morphogenesis Muscular Septum Morphogenesis Outflow Tract Morphogenesis Ventricular Compact Myocardium Morphogenesis Immune Response Transforming Growth Factor Beta Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Complex Assembly Positive Regulation Of Gene Expression Cell Migration Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Migration BMP Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Animal Organ Regeneration Response To Follicle-stimulating Hormone Response To Prostaglandin E Response To Luteinizing Hormone Intracellular Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of JNK Cascade Negative Regulation Of Epithelial Cell Proliferation Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Definitive Hemopoiesis Cardiac Epithelial To Mesenchymal Transition Definitive Erythrocyte Differentiation Heart Trabecula Formation Positive Regulation Of SMAD Protein Signal Transduction Negative Regulation Of SMAD Protein Signal Transduction Ventricular Septum Morphogenesis Epicardium-derived Cardiac Fibroblast Cell Development Vasculogenesis Involved In Coronary Vascular Morphogenesis Heart Trabecula Morphogenesis Secondary Palate Development Protein-containing Complex Assembly Regulation Of ERK1 And ERK2 Cascade Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Extracellular Matrix Assembly
Pathways		None	Signaling by Activin Signaling by Activin FGFR1b ligand binding and activation FGFR1c ligand binding and activation Signaling by BMP TGF-beta receptor signaling activates SMADs TGFBR3 PTM regulation TGFBR3 regulates TGF-beta signaling TGFBR3 expression TGFBR3 regulates FGF2 signaling TGFBR3 regulates activin signaling
GWAS		No GWAS studies recorded	Appendicular lean mass ( 33097823 ) Bone mineral density ( 19249006 ) Carotid plaque burden ( 28282560 ) dexamethasone sensitivity in B-cell precursor acute lymphoblastic leukaemia ( 33002292 ) Gestational age at birth (maternal effect) ( 28877031 ) Glaucoma (primary open-angle) ( 33627673 25861811 ) HDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931 ) Heel bone mineral density ( 30598549 ) HOMA-B (corrected for HOMA-IR) ( 30369944 ) Lung function (FEV1/FVC) ( 30804560 28166213 ) Lung function (FVC) ( 26635082 30804560 ) Metamizole-induced agranulocytosis or neutropenia ( 33138277 ) Multiple sclerosis ( 31604244 ) Optic disc area ( 25631615 21307088 28073927 31798171 ) Optic disc parameters ( 20548946 ) Optic disc size ( 31809533 ) Optic nerve measurement (cup-to-disc ratio) ( 28061514 ) Peak expiratory flow ( 30804560 ) Pulse pressure ( 30224653 ) QT interval (tricyclic/tetracyclic antidepressant use interaction) ( 28039329 ) Type 2 diabetes ( 23209189 ) Vertical cup-disc ratio ( 31798171 28073927 25241763 ) Vertical cup-disc ratio (multi-trait analysis) ( 31959993 )
Novel Interactors		1 novel interactors: CCDC24	None recorded
Interacting Genes		7 interacting genes: ACVR2A ENG MDFI PPP1CA PPP1CC TGFBR2 TGFBR3	13 interacting genes: ACVR2A ARRB2 DYNLT4 ENG GIPC1 INHA INHBA NRP1 SDC2 TGFB1 TGFB2 TGFB3 TGFBR2
Entrez ID		343521	7049
HPRD ID		15762	02846
Ensembl ID		ENSG00000188396	ENSG00000069702
Uniprot IDs		Q5JR98	A0A0A8KWK3 Q03167
PDB IDs		Not available	7LBG
GO Terms Enriched among Interactors		Activin Binding Positive Regulation Of SMAD Protein Signal Transduction Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Binding Glycosaminoglycan Binding Inhibin-betaglycan-ActRII Complex Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Receptor Complex Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Coreceptor Activity Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Vasculogenesis Activin Receptor Complex Activin Receptor Activity, Type I Cardiac Septum Morphogenesis PTW/PP1 Phosphatase Complex Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Activity BMP Signaling Pathway Epithelial To Mesenchymal Transition Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Type II Transforming Growth Factor Beta Receptor Binding Anatomical Structure Morphogenesis Type I Transforming Growth Factor Beta Receptor Binding Transforming Growth Factor Beta Receptor Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Activity Mesenchymal Cell Differentiation Secondary Palate Development Tissue Morphogenesis Branching Morphogenesis Of An Epithelial Tube Embryonic Morphogenesis Endocardial Cushion Morphogenesis Morphogenesis Of A Branching Epithelium Heart Trabecula Morphogenesis BMP Binding Morphogenesis Of A Branching Structure Entrainment Of Circadian Clock By Photoperiod Animal Organ Morphogenesis Aorta Morphogenesis Protein Phosphatase 1 Binding Outflow Tract Septum Morphogenesis Negative Regulation Of SMAD Protein Signal Transduction Cardiac Epithelial To Mesenchymal Transition Photoperiodism Entrainment Of Circadian Clock Activin Receptor Signaling Pathway Cardiac Ventricle Morphogenesis Branching Involved In Blood Vessel Morphogenesis	Positive Regulation Of SMAD Protein Signal Transduction Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of SMAD Protein Signal Transduction Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Type III Transforming Growth Factor Beta Receptor Binding Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Type II Transforming Growth Factor Beta Receptor Binding Transforming Growth Factor Beta Receptor Signaling Pathway Type I Transforming Growth Factor Beta Receptor Binding Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Cell Differentiation Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Outflow Tract Septum Morphogenesis Gland Morphogenesis Odontogenesis Regulation Of Cell Differentiation Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Multicellular Organismal Process Heart Development Regulation Of Developmental Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Animal Organ Morphogenesis Salivary Gland Morphogenesis Positive Regulation Of Developmental Process Activin Binding Response To Growth Factor Growth Factor Activity Negative Regulation Of Macrophage Cytokine Production Cell Surface Receptor Signaling Pathway Animal Organ Development Negative Regulation Of Cytokine Production Secondary Palate Development Anatomical Structure Morphogenesis Artery Morphogenesis Vasculogenesis Positive Regulation Of Cardiocyte Differentiation Transforming Growth Factor Beta Receptor Binding System Development Cardiac Septum Morphogenesis Response To Wounding Roof Of Mouth Development Cytokine Activity