TGFBI and S100P

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TGFBI	S100P
Description		transforming growth factor beta induced	S100 calcium binding protein P
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GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space Trans-Golgi Network Plasma Membrane Extracellular Matrix Extracellular Exosome Cell Periphery	Extracellular Region Nucleus Nucleoplasm Cytoplasm Plasma Membrane Membrane Microvillus Membrane Secretory Granule Lumen Cell Projection Extracellular Exosome
	Molecular Function	Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Collagen Binding Identical Protein Binding Cell Adhesion Molecule Binding Extracellular Matrix Binding	Magnesium Ion Binding Calcium Ion Binding Protein Binding Identical Protein Binding Protein Homodimerization Activity Cadherin Binding Metal Ion Binding Transition Metal Ion Binding Calcium-dependent Protein Binding
	Biological Process	Angiogenesis Chondrocyte Differentiation Cell Adhesion Negative Regulation Of Cell Adhesion Visual Perception Cell Population Proliferation Extracellular Matrix Organization	Endothelial Cell Migration
Pathways		Amyloid fiber formation	Neutrophil degranulation
Drugs			Cromoglicic acid
Diseases		Reis-Bucklers corneal dystrophy (RBCD); Corneal dystrophy of Bowman's type I; Granular corneal dystrophy type III Lattice corneal dystrophies (LCD), including: Biber-Haab-Dimmer dystrophy; Familial amyloid polyneuropathy type IV; Meretoja syndrome Thiel-Behnke dystrophies (TBCD); Corneal dystrophy of Bowman layer type II; Honeycomb corneal dystrophy; Anterior limiting membrane dystrophy type II; Curly fibers corneal dystrophy; Waardenburg-Jonker corneal dystrophy Granular corneal dystrophies (GCD), including: Corneal dystrophy Groenouw type I; Avellino corneal dystrophy; Granular-lattice dystrophy
GWAS		Blood protein levels ( 30072576) Insomnia ( 27992416) Response to cytidine analogues (gemcitabine) ( 24483146) Stroke ( 26089329)	Obesity-related traits ( 23251661)
Interacting Genes		15 interacting genes: A2M COL1A1 COL1A2 COL2A1 COL4A1 COL4A2 COL4A3 COL4A4 FAM9B FBXL17 FN1 LINC00632 LINC01554 MMP9 S100P	46 interacting genes: AGER ARC CACYBP CEBPA CLCF1 CNTF CSF2 CSF3 CTF1 EBI3 EPO EZR GH1 GH2 IFNB1 IFNW1 IL10 IL11 IL12A IL13 IL15 IL20 IL21 IL22 IL24 IL26 IL27 IL3 IL31 IL5 IL9 LEP OSM PRL S100A1 S100A2 S100A4 S100B S100Z STUB1 SUGT1 TERF2IP TFIP11 TGFBI THPO UBL4A
Entrez ID		7045	6286
HPRD ID		03409	02792
Ensembl ID		ENSG00000120708	ENSG00000163993
Uniprot IDs		A0A0S2Z4Q2 Q15582	P25815
PDB IDs		1X3B 2LTB 2LTC 2VXP 5NV6 7AS7 7ASC 7ASG 8HGA 8HIA	1J55 1OZO 2MJW 7NMI
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Structural Constituent Conferring Tensile Strength Extracellular Matrix Structural Constituent Collagen Trimer Extracellular Matrix Collagen Type IV Trimer Extracellular Matrix Organization Extracellular Structure Organization Endoplasmic Reticulum Lumen Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Platelet-derived Growth Factor Binding Basement Membrane Collagen-activated Signaling Pathway Fibrillar Collagen Trimer Extracellular Region Collagen Type I Trimer Protease Binding Endodermal Cell Differentiation Enzyme-linked Receptor Protein Signaling Pathway Skeletal System Development Collagen Fibril Organization Collagen Metabolic Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Glomerular Basement Membrane Development Cellular Response To Amino Acid Stimulus Skin Morphogenesis Proteoglycan Binding Cartilage Development Involved In Endochondral Bone Morphogenesis Response To Amino Acid Cell Surface Receptor Signaling Pathway Developmental Process System Development Sensory Perception Of Sound Endochondral Ossification Sensory Perception Of Mechanical Stimulus Cellular Developmental Process Cell Differentiation Anatomical Structure Formation Involved In Morphogenesis Cellular Response To Vitamin E Protein Heterotrimerization Iron-cytochrome-c Reductase Activity Positive Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Nitric Oxide Dioxygenase NAD(P)H Activity Nitrate Catabolic Process Extracellular Space Cellular Response To Transforming Growth Factor Beta Stimulus Platelet Alpha Granule Lumen Collagen Binding Negative Regulation Of Complement Activation, Lectin Pathway Cellular Response To Fluoride Nitric Oxide Catabolic Process	Cytokine Activity Extracellular Space Cytokine-mediated Signaling Pathway Extracellular Region Growth Factor Activity Positive Regulation Of Cell Population Proliferation Regulation Of Cell Population Proliferation Signal Transduction Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Leukocyte Proliferation Regulation Of Mononuclear Cell Proliferation Cytokine Receptor Binding Cell Surface Receptor Signaling Pathway Positive Regulation Of Leukocyte Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Multicellular Organismal Process Regulation Of Receptor Signaling Pathway Via JAK-STAT Leukocyte Differentiation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Receptor Signaling Pathway Via STAT Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Lymphocyte Activation Positive Regulation Of Developmental Process Regulation Of Cell Activation Immune System Process Cell Activation Positive Regulation Of Metabolic Process Leukocyte Activation S100 Protein Binding Positive Regulation Of Protein Modification Process Positive Regulation Of Cell Activation Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cytokine Production Immune Response Positive Regulation Of Phosphorylation Positive Regulation Of Gene Expression Positive Regulation Of Lymphocyte Activation Regulation Of T Cell Proliferation Positive Regulation Of Protein Metabolic Process Regulation Of Cytokine Production Regulation Of Developmental Process Regulation Of Protein Phosphorylation Regulation Of T Cell Activation
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