TGFBI and COL4A3

Number of citations of the paper that reports this interaction (PMID 11867580)
19

Data Source:
HPRD (in vitro)

		TGFBI	COL4A3
Gene Name		transforming growth factor, beta-induced, 68kDa	collagen, type IV, alpha 3 (Goodpasture antigen)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Basement Membrane Extracellular Space Trans-Golgi Network Plasma Membrane Extracellular Matrix Extracellular Vesicular Exosome	Extracellular Region Collagen Type IV Trimer Basement Membrane Endoplasmic Reticulum Lumen
	Molecular Function	Integrin Binding Protein Binding Collagen Binding Extracellular Matrix Binding	Integrin Binding Structural Molecule Activity Extracellular Matrix Structural Constituent Protein Binding Metalloendopeptidase Inhibitor Activity
	Biological Process	Angiogenesis Chondrocyte Differentiation Cell Adhesion Negative Regulation Of Cell Adhesion Visual Perception Cell Proliferation Extracellular Matrix Organization Response To Stimulus	Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Adhesion Cell Surface Receptor Signaling Pathway Axon Guidance Sensory Perception Of Sound Blood Circulation Cell Proliferation Negative Regulation Of Cell Proliferation Negative Regulation Of Endopeptidase Activity Negative Regulation Of Angiogenesis Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Glomerular Basement Membrane Development Endothelial Cell Apoptotic Process
Pathways		Amyloids	Signaling by PDGF NCAM1 interactions Collagen formation Axon guidance Collagen degradation Anchoring fibril formation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Laminin interactions ECM proteoglycans Integrin cell surface interactions Collagen biosynthesis and modifying enzymes NCAM signaling for neurite out-growth
Drugs
Diseases
GWAS			Corneal structure ( 23291589) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000)
Protein-Protein Interactions		10 interactors: A2M COL1A1 COL1A2 COL2A1 COL4A1 COL4A2 COL4A3 COL4A4 FAM9B FN1	17 interactors: ANTXR2 APP CAMK2B CD93 COL4A3BP DCN FBLN2 FN1 HABP2 MATN2 MFAP2 MMP9 OSM SAA1 SERPINE2 TGFBI USH2A
Entrez ID		7045	1285
HPRD ID		03409	00354
Ensembl ID		ENSG00000120708	ENSG00000169031
Uniprot IDs		Q15582	Q01955
PDB IDs		1X3B 2LTB 2VXP
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Disassembly Collagen Catabolic Process Extracellular Matrix Organization Extracellular Structure Organization Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Locomotion Movement Of Cell Or Subcellular Component Cell Morphogenesis Involved In Differentiation Anatomical Structure Morphogenesis Axon Guidance Cardiovascular System Development Catabolic Process Platelet Activation Blood Vessel Development Cell Morphogenesis Axonogenesis Vasculature Development Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Cellular Response To Amino Acid Stimulus Collagen Fibril Organization Cell Differentiation Neuron Projection Morphogenesis Developmental Process Vesicle-mediated Transport Neuron Projection Development Receptor-mediated Endocytosis Generation Of Neurons Cell Projection Morphogenesis Cell Part Morphogenesis System Development Protein Heterotrimerization Neurogenesis Response To Amino Acid Blood Coagulation Neuron Development Hemostasis Cell Development Response To External Stimulus Glomerular Basement Membrane Development Anatomical Structure Formation Involved In Morphogenesis Multicellular Organismal Development Sensory Perception Of Sound Anatomical Structure Development Neuron Differentiation Cell Projection Organization Cellular Response To Acid Chemical	Extracellular Matrix Organization Extracellular Structure Organization System Development Immune System Process Response To Wounding Multicellular Organismal Development Anatomical Structure Development Anatomical Structure Morphogenesis Extracellular Matrix Disassembly Developmental Process Wound Healing Generation Of Neurons Cell Morphogenesis Nervous System Development Neurogenesis Cell Activation Cell Morphogenesis Involved In Differentiation Blood Coagulation Cell Differentiation Reproductive Process Hemostasis Response To Stress Platelet Activation Endodermal Cell Differentiation Acute-phase Response Regulation Of Meiosis Peptide Cross-linking Organ Development Leukocyte Migration Mating Regulation Of Body Fluid Levels Regulation Of Meiotic Cell Cycle Chemotaxis Endoderm Formation Response To Abiotic Stimulus Regulation Of Growth Seminal Vesicle Epithelium Development Dendrite Regeneration Inhibitory G-protein Coupled Receptor Phosphorylation Regulation Of Cell Adhesion Tissue Development Neurological System Process Response To External Stimulus Cell Adhesion Platelet Degranulation Regulation Of Neurogenesis Acute Inflammatory Response Locomotion Neuromuscular Process Controlling Balance Synaptic Growth At Neuromuscular Junction
Tagcloud ?		alignment arrangements articular bigh3 biglycan cartilage chondrocytic collagen collagens crossing decorin forming healing heterozygous knockout maintaining matrix metalloproteinase mineral mmp13 plates preparation safranin skeletal smaller transforming trichrome tumorigenesis wound	alport amplified aras ascending audiological audiometric august autosomal certainly curves descending drop eighty exons fibroblast flat groove hearing impairment inheritance moderate oae recessive sensorineural sequenced sixteen wherein xlas
Tagcloud (Difference) ?		alignment arrangements articular bigh3 biglycan cartilage chondrocytic collagen collagens crossing decorin forming healing heterozygous knockout maintaining matrix metalloproteinase mineral mmp13 plates preparation safranin skeletal smaller transforming trichrome tumorigenesis wound	alport amplified aras ascending audiological audiometric august autosomal certainly curves descending drop eighty exons fibroblast flat groove hearing impairment inheritance moderate oae recessive sensorineural sequenced sixteen wherein xlas
Tagcloud (Intersection) ?