SDCBP and CALM3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SDCBP	CALM3
Description		syndecan binding protein	calmodulin 3
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Plasma Membrane Interleukin-5 Receptor Complex Adherens Junction Focal Adhesion Membrane Nuclear Membrane Azurophil Granule Lumen Melanosome Membrane Raft Synapse Extracellular Exosome Anchoring Junction Blood Microparticle Extracellular Vesicle	Spindle Pole Nucleus Cytoplasm Mitochondrion Centrosome Spindle Cytoskeleton Spindle Microtubule Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Sarcomere Growth Cone Synaptic Vesicle Membrane Mitochondrial Membrane Vesicle Protein-containing Complex Calcium Channel Complex Myelin Sheath Calyx Of Held Sperm Midpiece Schaffer Collateral - CA1 Synapse Presynaptic Cytosol Postsynaptic Cytosol Catalytic Complex
	Molecular Function	Frizzled Binding Interleukin-5 Receptor Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Cytoskeletal Anchor Activity Lipid Binding Identical Protein Binding Syndecan Binding Protein Heterodimerization Activity Protein Sequestering Activity	Calcium Channel Regulator Activity Calcium Ion Binding Protein Binding Adenylate Cyclase Binding Adenylate Cyclase Activator Activity Protein Kinase Binding Protein Domain Specific Binding Nitric-oxide Synthase Regulator Activity Titin Binding Type 3 Metabotropic Glutamate Receptor Binding Protein Serine/threonine Kinase Activator Activity Phosphatidylinositol 3-kinase Binding Transmembrane Transporter Binding Metal Ion Binding Calcium-dependent Protein Binding Nitric-oxide Synthase Binding Protein Phosphatase Activator Activity Transporter Inhibitor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Receptor Internalization Protein Targeting To Membrane Substrate-dependent Cell Migration, Cell Extension Ras Protein Signal Transduction Chemical Synaptic Transmission Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Population Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Actin Cytoskeleton Organization Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Phosphorylation Positive Regulation Of JNK Cascade Positive Regulation Of Exosomal Secretion Positive Regulation Of Extracellular Exosome Assembly	G2/M Transition Of Mitotic Cell Cycle Response To Amphetamine Regulation Of Heart Rate Detection Of Calcium Ion G Protein-coupled Receptor Signaling Pathway Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Substantia Nigra Development Regulation Of Cytokinesis Regulation Of Calcium-mediated Signaling Response To Corticosterone Response To Calcium Ion Regulation Of Cardiac Muscle Contraction Long-term Synaptic Potentiation Establishment Of Protein Localization To Membrane Establishment Of Protein Localization To Mitochondrial Membrane Calcineurin-mediated Signaling Regulation Of Cardiac Muscle Cell Action Potential Presynaptic Endocytosis Regulation Of Synaptic Vesicle Endocytosis Negative Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Synaptic Vesicle Exocytosis
Pathways		Ephrin signaling Neurofascin interactions RIPK1-mediated regulated necrosis Regulation of necroptotic cell death Neutrophil degranulation	CaMK IV-mediated phosphorylation of CREB CaMK IV-mediated phosphorylation of CREB Calmodulin induced events Cam-PDE 1 activation CaM pathway Platelet degranulation Translocation of SLC2A4 (GLUT4) to the plasma membrane Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation PKA activation DARPP-32 events Synthesis of IP3 and IP4 in the cytosol Calcineurin activates NFAT Calcineurin activates NFAT eNOS activation Transcriptional activation of mitochondrial biogenesis Inactivation, recovery and regulation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Stimuli-sensing channels FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization Ca2+ pathway Reduction of cytosolic Ca++ levels Sodium/Calcium exchangers Unblocking of NMDA receptors, glutamate binding and activation CREB1 phosphorylation through the activation of Adenylate Cyclase CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Ras activation upon Ca2+ influx through NMDA receptor Smooth Muscle Contraction Smooth Muscle Contraction Activation of Ca-permeable Kainate Receptor Uptake and function of anthrax toxins VEGFR2 mediated vascular permeability VEGFR2 mediated cell proliferation Phase 0 - rapid depolarisation Ion homeostasis CLEC7A (Dectin-1) induces NFAT activation CLEC7A (Dectin-1) induces NFAT activation RHO GTPases activate IQGAPs RHO GTPases activate PAKs RHO GTPases activate PAKs RAF activation RAF/MAP kinase cascade Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Glycogen breakdown (glycogenolysis) Glycogen breakdown (glycogenolysis) Protein methylation Extra-nuclear estrogen signaling Loss of phosphorylation of MECP2 at T308 Regulation of MECP2 expression and activity Ion transport by P-type ATPases Negative regulation of NMDA receptor-mediated neuronal transmission Activation of RAC1 downstream of NMDARs Activation of RAC1 downstream of NMDARs Activation of AMPK downstream of NMDARs Long-term potentiation Long-term potentiation RAS processing Signaling downstream of RAS mutants Signaling by RAF1 mutants FCGR3A-mediated IL10 synthesis FCGR3A-mediated IL10 synthesis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells CASP4 inflammasome assembly Microbial factors inhibit CASP4 activity CASP4 inflammasome assembly Microbial factors inhibit CASP4 activity CASP4 inflammasome assembly Microbial factors inhibit CASP4 activity
Drugs			Chlorpromazine Cinchocaine Nicardipine Fluphenazine Isoflurane Trifluoperazine Loperamide Perphenazine Phenoxybenzamine Felodipine Melatonin Promethazine Pimozide Nifedipine Bepridil Calcium Aprindine Deacetoxyvinzolidine tert-butanol Trimethyllysine Dequalinium N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide Prenylamine Flunarizine (3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-INDOL-2-YLMETHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-5-SULFONAMIDE Myristic acid Calcium citrate Calcium citrate Calcium citrate Calcium Phosphate Calcium Phosphate Calcium Phosphate Calcium levulinate Calcium phosphate dihydrate Calcium phosphate dihydrate Calcium phosphate dihydrate
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Fasting insulin ( 34074324) Low density lipoprotein cholesterol levels ( 32154731) Lymphocyte count ( 32888494) Monocyte count ( 32888494) Triglyceride levels ( 32154731)	Crohn's disease ( 28067908) Immature fraction of reticulocytes ( 32888494) Ulcerative colitis ( 23128233)
Interacting Genes		308 interacting genes: - ABI2 AIRIM ANKRD33 ANKRD36B ANKRD40 ANP32B APIP ARFIP2 ARL6IP1 BCL2L15 BEND7 C11orf68 C1orf35 C2CD2L CABP5 CADM1 CADPS CALCOCO2 CALM1 CALM2 CALM3 CAV2 CBR3 CBY2 CCDC102B CCDC106 CD6 CD63 CDA CDC34 CDCP1 CDIPT CDKN2D CEP55 CEP85 CGGBP1 CHIC2 CHMP1A CLK2 CLK3 CMTM5 COX4I1 CRX CRYAA CT45A1 CT45A10 CT45A3 CT45A5 CTBP2 CTDSP1 CUTC DCTD DCTPP1 DDX39B DERL3 DMC1 DNM2 DRAP1 DTNBP1 DYNLT1 EAF1 EDARADD EFNB1 EFNB2 EIF1AD EIF5A EIF5A2 ELAVL1 EMILIN3 ENOX1 ENTR1 EPHB2 ERICH2 EXOSC4 FADD FAM118A FAM118B FAM9A FAM9B FHL3 FHL5 FLAD1 FOXP2 FTH1 FTL GET4 GGPS1 GKAP1 GNMT GOLT1B GPATCH11 GPR37 GRIA1 GRIA2 GRIA3 GRIA4 GRIK1 GRIK2 GRM2 GRM3 GRM7 GRXCR1 GSC2 GSG1 HEXIM2 HHAT HIVEP1 HMBOX1 HMGB3 HNRNPC HOMER3 HOMEZ HOXA1 HOXA7 HPRT1 HSBP1 HSF2BP HUS1 ID3 IGFBP6 IHO1 IKZF1 IL5RA INO80E KATNBL1 KCNH1 KCNJ2 KCTD1 KCTD6 KCTD9 KHDRBS2 KLHL12 KLHL2 KRT14 KRTAP1-3 KRTAP1-5 KRTAP10-3 KRTAP10-7 KRTAP5-9 LCOR LDB2 LDHB LDOC1 LEPROTL1 LGALS2 LSM6 LURAP1L LZTFL1 MAD2L1 MAPK9 MAPRE3 MATN4 MBD3 MED4 MEOX1 MEOX2 MGLL MID2 MINDY3 MKRN1 MOBP MRFAP1 MRFAP1L1 MTUS2 MYBPC2 MYLIP N4BP3 NADK NAGK NAPB NECAB2 NF2 NFASC NKAPD1 NOTCH2NLA NT5C2 OCM ODAM OPTN OSTF1 PCBD1 PCYT1A PDCD6IP PDE4DIP PDE9A PDLIM4 PDZK1IP1 PFDN5 PHC2 PHF11 PIH1D2 PNMA1 PNMA2 POLR2J POLR3K PPARA PRPF38A PRPF40A PRR13 PSMB3 PSMC6 PSTPIP1 PTEN PTPRJ PTS PUF60 PYCR3 RAB5A RALY RBM39 REEP6 REL RIC8A RNF11 RNH1 ROPN1 RP9 RP9P RPIA RPL22 RPRD1A RPRM RPS26 RRM2 RRS1 RTL8B RTN1 RUNDC3A S100B SCG3 SCML1 SDC1 SDC2 SDC4 SDCBP2 SEPTIN1 SEPTIN3 SET SFT2D1 SIAH1 SLC50A1 SLC6A5 SMARCA2 SNRPA SNX1 SOX4 SPANXN3 SREK1IP1 SRSF11 SRSF3 SRSF7 SSC5D SSNA1 STX1A SUB1 SULT1B1 SYNGR1 SYPL1 SYS1 TCF21 TCF4 TDO2 TEKT1 TFCP2 TGFA THG1L TIFA TKFC TLE5 TMCO2 TMEM17 TMEM239 TNFAIP8 TNFAIP8L3 TNKS TRAF5 TRARG1 TRIM27 TRIM32 TRIM38 TRIM54 TRIP13 TSN UBB UBC UBE2A UBE2K UBE2R2 ULK1 WASHC1 WASHC3 WASL WDR91 YAP1 YIF1A ZBTB14 ZBTB8A ZCCHC10 ZCCHC17 ZFTRAF1 ZMYND12 ZNF343 ZNF485 ZNF660 ZNF768 ZRANB1 ZSCAN23	49 interacting genes: AKAP9 APPBP2 ASCL2 C11orf65 C5AR2 CACNA1A CALD1 CAMTA2 CCND2 CCP110 CHRM3 CLEC7A DDIT4L DRC9 DRD2 EDF1 EGFR ESR1 ESR2 GRM5 GRM7 GSC2 INSR IQCE IQCN IQSEC2 KCNN1 KCNQ2 KCNQ3 KCNQ5 MINK1 MYF5 MYF6 MYOD1 MYOG NEUROD1 NSMF PLCB3 POC5 PPEF1 PPEF2 RAB3B SDCBP SPATA17 TBC1D1 TCF3 TCF4 TRIM54 ZNF280A
Entrez ID		6386	808
HPRD ID		03741	00243
Ensembl ID		ENSG00000137575	ENSG00000160014
Uniprot IDs		B4DHN5 G5EA09 O00560	B4DJ51 P0DP23 P0DP24 P0DP25 Q96HY3 Q9BRL5
PDB IDs		1N99 1NTE 1OBX 1OBY 1OBZ 1R6J 1V1T 1W9E 1W9O 1W9Q 1YBO 4Z33 6R9H 6RLC 7FSG 7FSH 7FSI 7FSJ 7FSK 7FSL 7FSM 7FSN 7FSO 7FSP 7FSQ 7FSR 7FSS 7FST 7FSU 7FSV 7FSW 7FSX 7FSY 7FSZ 7FT0 7FT1 7FT2 7FT3 7FT4 7FT5 7FT6 7FT7 7FT8 7FT9 7FTA 7FTB 7FTC 7FTD 8AAI 8AAK 8AAO 8AAP 8BLU 8BLV 8HCK	1CDL 1CLL 1CTR 1IWQ 1J7O 1J7P 1K90 1K93 1L7Z 1LVC 1NKF 1PK0 1S26 1SK6 1SW8 1UP5 1WRZ 1XFU 1XFV 1XFW 1XFX 1XFY 1XFZ 1Y6W 1YR5 1YRT 1YRU 1ZOT 1ZUZ 2BE6 2F3Y 2F3Z 2HF5 2I08 2JZI 2K0E 2K0F 2K0J 2K61 2KNE 2KUG 2KUH 2L53 2L7L 2LGF 2LL6 2LL7 2LQC 2LQP 2LV6 2M0J 2M0K 2M55 2MG5 2N27 2N6A 2N77 2N8J 2R28 2V01 2V02 2VAY 2W73 2WEL 2X0G 2Y4V 3BYA 3DVE 3DVJ 3DVK 3DVM 3EVV 3EWT 3EWV 3G43 3HR4 3J41 3O77 3O78 3OXQ 3SUI 3UCT 3UCW 3UCY 4BW7 4BW8 4BYF 4DCK 4DJC 4GOW 4JPZ 4JQ0 4L79 4LZX 4M1L 4OVN 4Q57 4Q5U 4UMO 4UPU 4V0C 5COC 5DBR 5DOW 5DSU 5GGM 5I0I 5J03 5J8H 5JQA 5JTH 5K7L 5K8Q 5NIN 5OEO 5TP5 5TP6 5V02 5V03 5V7X 5VMS 5WBX 5WC5 5WSU 5WSV 6B8L 6B8M 6B8N 6B8P 6B8Q 6BUT 6C1D 6C1G 6C1H 6CNM 6CNN 6CNO 6DAD 6DAE 6DAF 6DAH 6E2F 6E2G 6EEB 6FEG 6FEH 6GDK 6GDL 6HCS 6HR1 6JI8 6JII 6JIU 6JIY 6JRS 6JV2 6K4K 6K4L 6K4R 6K67 6M2W 6M7H 6MUD 6MUE 6N5W 6O5G 6OS4 6PAW 6PBX 6PBY 6PLM 6S5T 6SZ5 6TV7 6U39 6U3A 6U3B 6U3D 6UZZ 6V00 6V01 6X32 6X33 6X35 6X36 6XXF 6XXX 6XY3 6XYR 6Y4O 6Y4P 6Y94 6Y95 6YA9 6YNS 6YNU 6ZBI 7AUG 7BF1 7BF2 7BYL 7BYM 7BYN 7CR3 7CR4 7CR7 7KL5 7L8V 7MIR 7MIS 7PPO 7PQE 7PSZ 7PU9 7SHQ 7SX3 7SX4 7T2Q 7TCI 7TCP 7TZC 7U9T 7UA3 7UA4 7VMB 7VNP 7VNQ 7VNR 7VUO 7VUR 7VUS 7VUT 7VUU 7VVD 7VVH 7WJI 7WR3 7WR4 7WR5 7WZS 7XN4 7XN5 7XN6 7XNI 7XNK 7XNL 7XNN 7ZRP 7ZRQ 8AHS 8B6Q 8BD2 8BFG 8DGH 8DGK 8DUJ 8DVE 8EOW 8EP0 8EP1 8FNY 8FO6 8GM4 8GM5 8IJK 8J00 8J01 8J02 8J03 8J04 8J05 8J07 8JFK 8K9Z 8KA0 8KA1 8ODZ 8OE0 8OE4 8PB1 8SIK 8SIM 8SIN 8UXL 8UXM 8W4U 8X43 8XJI 8XKH 8XLF 8XLH 8XO1 8XYA 8XYB 8Y40 9CUI 9CUK 9E17 9JQI 9K8W 9K8X
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Protein Binding Glutamate-gated Receptor Activity Glutamate Receptor Signaling Pathway AMPA Glutamate Receptor Activity Nucleus Glutamate-gated Calcium Ion Channel Activity Synaptic Transmission, Glutamatergic Ionotropic Glutamate Receptor Signaling Pathway Cytosol Postsynaptic Membrane Ligand-gated Monoatomic Ion Channel Activity Positive Regulation Of Extracellular Exosome Assembly Regulation Of Actin Nucleation Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Positive Regulation Of Synaptic Transmission Endocytic Vesicle Membrane Protein Homooligomerization Protein Complex Oligomerization Asymmetric Synapse Protein Tetramerization Glutamate Receptor Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Nucleoplasm Dendritic Spine Ligand-gated Ion Channel Signaling Pathway Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Modulation Of Chemical Synaptic Transmission Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Extracellular Exosome Assembly Postsynaptic Density Membrane Protein Homotetramerization Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential G Protein-coupled Glutamate Receptor Signaling Pathway Presynaptic Membrane Ferric Iron Binding Phosphatidylinositol 3-kinase Inhibitor Activity Female Meiosis I Calcium Channel Regulator Activity Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Membrane Tubulation Ferritin Complex Group II Metabotropic Glutamate Receptor Activity Regulation Of Synaptic Plasticity Regulation Of Synaptic Transmission, Glutamatergic Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Long-term Synaptic Potentiation	E-box Binding Chemical Synaptic Transmission Protein Dimerization Activity Trans-synaptic Signaling Synaptic Signaling Calmodulin Binding Positive Regulation Of Skeletal Muscle Fiber Development Regulation Of Skeletal Muscle Fiber Development Cellular Response To Estradiol Stimulus Muscle Cell Fate Commitment Cell-cell Signaling Signaling Positive Regulation Of Skeletal Muscle Tissue Development Cell Communication Positive Regulation Of Striated Muscle Tissue Development Regulation Of Skeletal Muscle Tissue Development Response To Estradiol Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Voltage-gated Potassium Channel Complex DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Sequence-specific DNA Binding Regulation Of Striated Muscle Tissue Development Chromatin Positive Regulation Of Striated Muscle Cell Differentiation Regulation Of Muscle Organ Development Regulation Of Myotube Differentiation Positive Regulation Of Myoblast Differentiation Cell Fate Commitment RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Euchromatin Cellular Response To Oxygen-containing Compound Positive Regulation Of Cell Differentiation Skeletal Muscle Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Transcription Regulator Complex DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Skeletal Muscle Tissue Development Nuclear Estrogen Receptor Activity TFIIB-class Transcription Factor Binding Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Developmental Process Positive Regulation Of Muscle Cell Differentiation BHLH Transcription Factor Binding Regulation Of Developmental Process Regulation Of Myoblast Differentiation Positive Regulation Of RNA Metabolic Process
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