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SDCBP and PSMB3
Number of citations of the paper that reports this interaction (PubMedID
32296183
)
50
Data Source:
BioGRID
(two hybrid)
SDCBP
PSMB3
Description
syndecan binding protein
proteasome 20S subunit beta 3
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Nucleus
Nucleoplasm
Cytoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Cytosol
Cytoskeleton
Plasma Membrane
Interleukin-5 Receptor Complex
Adherens Junction
Focal Adhesion
Membrane
Nuclear Membrane
Azurophil Granule Lumen
Melanosome
Membrane Raft
Synapse
Extracellular Exosome
Anchoring Junction
Blood Microparticle
Extracellular Vesicle
Proteasome Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Proteasome Core Complex
Proteasome Core Complex, Beta-subunit Complex
Extracellular Exosome
Molecular Function
Frizzled Binding
Interleukin-5 Receptor Binding
Protein Binding
Phosphatidylinositol-4,5-bisphosphate Binding
Cytoskeletal Anchor Activity
Lipid Binding
Identical Protein Binding
Syndecan Binding
Protein Heterodimerization Activity
Protein Sequestering Activity
Protein Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Receptor Internalization
Protein Targeting To Membrane
Substrate-dependent Cell Migration, Cell Extension
Ras Protein Signal Transduction
Chemical Synaptic Transmission
Regulation Of Mitotic Cell Cycle
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Epithelial To Mesenchymal Transition
Actin Cytoskeleton Organization
Positive Regulation Of Cell Growth
Positive Regulation Of Cell Migration
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Intracellular Signal Transduction
Positive Regulation Of Phosphorylation
Positive Regulation Of JNK Cascade
Positive Regulation Of Exosomal Secretion
Positive Regulation Of Extracellular Exosome Assembly
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Pathways
Ephrin signaling
Neurofascin interactions
RIPK1-mediated regulated necrosis
Regulation of necroptotic cell death
Neutrophil degranulation
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
Assembly of the pre-replicative complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
KEAP1-NFE2L2 pathway
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
Degradation of CDH1
Somitogenesis
Antigen processing: Ubiquitination & Proteasome degradation
Proteasome assembly
Proteasome assembly
Antigen processing: Ub, ATP-independent proteasomal degradation
GSK3B-mediated proteasomal degradation of PD-L1(CD274)
SPOP-mediated proteasomal degradation of PD-L1(CD274)
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Degradation of CRY and PER proteins
Degradation of CRY and PER proteins
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Drugs
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE
Diseases
GWAS
Aspartate aminotransferase levels (
33547301
)
Fasting insulin (
34074324
)
Low density lipoprotein cholesterol levels (
32154731
)
Lymphocyte count (
32888494
)
Monocyte count (
32888494
)
Triglyceride levels (
32154731
)
FEV1 (
30804560
)
Heel bone mineral density (
30598549
)
Lung function (FEV1/FVC) (
30804560
)
Peak expiratory flow (
30804560
)
Interacting Genes
308 interacting genes:
-
ABI2
AIRIM
ANKRD33
ANKRD36B
ANKRD40
ANP32B
APIP
ARFIP2
ARL6IP1
BCL2L15
BEND7
C11orf68
C1orf35
C2CD2L
CABP5
CADM1
CADPS
CALCOCO2
CALM1
CALM2
CALM3
CAV2
CBR3
CBY2
CCDC102B
CCDC106
CD6
CD63
CDA
CDC34
CDCP1
CDIPT
CDKN2D
CEP55
CEP85
CGGBP1
CHIC2
CHMP1A
CLK2
CLK3
CMTM5
COX4I1
CRX
CRYAA
CT45A1
CT45A10
CT45A3
CT45A5
CTBP2
CTDSP1
CUTC
DCTD
DCTPP1
DDX39B
DERL3
DMC1
DNM2
DRAP1
DTNBP1
DYNLT1
EAF1
EDARADD
EFNB1
EFNB2
EIF1AD
EIF5A
EIF5A2
ELAVL1
EMILIN3
ENOX1
ENTR1
EPHB2
ERICH2
EXOSC4
FADD
FAM118A
FAM118B
FAM9A
FAM9B
FHL3
FHL5
FLAD1
FOXP2
FTH1
FTL
GET4
GGPS1
GKAP1
GNMT
GOLT1B
GPATCH11
GPR37
GRIA1
GRIA2
GRIA3
GRIA4
GRIK1
GRIK2
GRM2
GRM3
GRM7
GRXCR1
GSC2
GSG1
HEXIM2
HHAT
HIVEP1
HMBOX1
HMGB3
HNRNPC
HOMER3
HOMEZ
HOXA1
HOXA7
HPRT1
HSBP1
HSF2BP
HUS1
ID3
IGFBP6
IHO1
IKZF1
IL5RA
INO80E
KATNBL1
KCNH1
KCNJ2
KCTD1
KCTD6
KCTD9
KHDRBS2
KLHL12
KLHL2
KRT14
KRTAP1-3
KRTAP1-5
KRTAP10-3
KRTAP10-7
KRTAP5-9
LCOR
LDB2
LDHB
LDOC1
LEPROTL1
LGALS2
LSM6
LURAP1L
LZTFL1
MAD2L1
MAPK9
MAPRE3
MATN4
MBD3
MED4
MEOX1
MEOX2
MGLL
MID2
MINDY3
MKRN1
MOBP
MRFAP1
MRFAP1L1
MTUS2
MYBPC2
MYLIP
N4BP3
NADK
NAGK
NAPB
NECAB2
NF2
NFASC
NKAPD1
NOTCH2NLA
NT5C2
OCM
ODAM
OPTN
OSTF1
PCBD1
PCYT1A
PDCD6IP
PDE4DIP
PDE9A
PDLIM4
PDZK1IP1
PFDN5
PHC2
PHF11
PIH1D2
PNMA1
PNMA2
POLR2J
POLR3K
PPARA
PRPF38A
PRPF40A
PRR13
PSMB3
PSMC6
PSTPIP1
PTEN
PTPRJ
PTS
PUF60
PYCR3
RAB5A
RALY
RBM39
REEP6
REL
RIC8A
RNF11
RNH1
ROPN1
RP9
RP9P
RPIA
RPL22
RPRD1A
RPRM
RPS26
RRM2
RRS1
RTL8B
RTN1
RUNDC3A
S100B
SCG3
SCML1
SDC1
SDC2
SDC4
SDCBP2
SEPTIN1
SEPTIN3
SET
SFT2D1
SIAH1
SLC50A1
SLC6A5
SMARCA2
SNRPA
SNX1
SOX4
SPANXN3
SREK1IP1
SRSF11
SRSF3
SRSF7
SSC5D
SSNA1
STX1A
SUB1
SULT1B1
SYNGR1
SYPL1
SYS1
TCF21
TCF4
TDO2
TEKT1
TFCP2
TGFA
THG1L
TIFA
TKFC
TLE5
TMCO2
TMEM17
TMEM239
TNFAIP8
TNFAIP8L3
TNKS
TRAF5
TRARG1
TRIM27
TRIM32
TRIM38
TRIM54
TRIP13
TSN
UBB
UBC
UBE2A
UBE2K
UBE2R2
ULK1
WASHC1
WASHC3
WASL
WDR91
YAP1
YIF1A
ZBTB14
ZBTB8A
ZCCHC10
ZCCHC17
ZFTRAF1
ZMYND12
ZNF343
ZNF485
ZNF660
ZNF768
ZRANB1
ZSCAN23
14 interacting genes:
CEBPA
CRACR2B
MPZ
PLK1
PRMT2
PSMB1
PSMB2
PSMB5
PSMB7
PSMG3
SDCBP
TP53
TRIM27
UBD
Entrez ID
6386
5691
HPRD ID
03741
03709
Ensembl ID
ENSG00000137575
ENSG00000277791
Uniprot IDs
B4DHN5
G5EA09
O00560
A0A384NL22
P49720
PDB IDs
1N99
1NTE
1OBX
1OBY
1OBZ
1R6J
1V1T
1W9E
1W9O
1W9Q
1YBO
4Z33
6R9H
6RLC
7FSG
7FSH
7FSI
7FSJ
7FSK
7FSL
7FSM
7FSN
7FSO
7FSP
7FSQ
7FSR
7FSS
7FST
7FSU
7FSV
7FSW
7FSX
7FSY
7FSZ
7FT0
7FT1
7FT2
7FT3
7FT4
7FT5
7FT6
7FT7
7FT8
7FT9
7FTA
7FTB
7FTC
7FTD
8AAI
8AAK
8AAO
8AAP
8BLU
8BLV
8HCK
4R3O
4R67
5A0Q
5GJQ
5GJR
5L4G
5LE5
5LEX
5LEY
5LEZ
5LF0
5LF1
5LF3
5LF4
5LF6
5LF7
5LN3
5M32
5T0C
5T0G
5T0H
5T0I
5T0J
5VFO
5VFP
5VFQ
5VFR
5VFS
5VFT
5VFU
6AVO
6E5B
6KWY
6MSB
6MSD
6MSE
6MSG
6MSH
6MSJ
6MSK
6R70
6REY
6RGQ
6WJD
6WJN
6XMJ
7AWE
7B12
7LXV
7NAN
7NAO
7NAP
7NAQ
7NHT
7PG9
7QXN
7QXP
7QXU
7QXW
7QXX
7QY7
7QYA
7QYB
7V5G
7V5M
7W37
7W38
7W39
7W3A
7W3B
7W3C
7W3F
7W3G
7W3H
7W3I
7W3J
7W3K
7W3M
8BZL
8CVR
8CVS
8CVT
8CXB
8QYL
8QYM
8QYN
8QYO
8QYS
8QZ9
8TM4
8TM5
8TM6
8UD9
8YIX
8YIY
8YIZ
9E8G
9E8O
9E8Q
9HMN
Enriched GO Terms of Interacting Partners
?
Identical Protein Binding
Protein Binding
Glutamate-gated Receptor Activity
Glutamate Receptor Signaling Pathway
AMPA Glutamate Receptor Activity
Nucleus
Glutamate-gated Calcium Ion Channel Activity
Synaptic Transmission, Glutamatergic
Ionotropic Glutamate Receptor Signaling Pathway
Cytosol
Postsynaptic Membrane
Ligand-gated Monoatomic Ion Channel Activity
Positive Regulation Of Extracellular Exosome Assembly
Regulation Of Actin Nucleation
Negative Regulation Of Calcium Ion Export Across Plasma Membrane
Adenylate Cyclase Activator Activity
Positive Regulation Of Synaptic Transmission
Endocytic Vesicle Membrane
Protein Homooligomerization
Protein Complex Oligomerization
Asymmetric Synapse
Protein Tetramerization
Glutamate Receptor Activity
Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
Nucleoplasm
Dendritic Spine
Ligand-gated Ion Channel Signaling Pathway
Transporter Inhibitor Activity
Regulation Of Calcium Ion Export Across Plasma Membrane
Modulation Of Chemical Synaptic Transmission
Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Regulation Of Extracellular Exosome Assembly
Postsynaptic Density Membrane
Protein Homotetramerization
Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential
G Protein-coupled Glutamate Receptor Signaling Pathway
Presynaptic Membrane
Ferric Iron Binding
Phosphatidylinositol 3-kinase Inhibitor Activity
Female Meiosis I
Calcium Channel Regulator Activity
Negative Regulation Of High Voltage-gated Calcium Channel Activity
Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity
Negative Regulation Of Membrane Tubulation
Ferritin Complex
Group II Metabotropic Glutamate Receptor Activity
Regulation Of Synaptic Plasticity
Regulation Of Synaptic Transmission, Glutamatergic
Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway
Long-term Synaptic Potentiation
Proteasome Core Complex, Beta-subunit Complex
Proteasome Core Complex
Proteasome Complex
Nucleoplasm
Threonine-type Endopeptidase Activity
Regulation Of Mitotic Cell Cycle
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteasome Assembly
Regulation Of Cell Cycle
Regulation Of Mitotic Cell Cycle Phase Transition
Negative Regulation Of Cell Cycle
Proteolysis Involved In Protein Catabolic Process
Negative Regulation Of Stem Cell Proliferation
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Cell Cycle Phase Transition
Cytosol
Proteasomal Protein Catabolic Process
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding
Negative Regulation Of Cell Cycle Phase Transition
Negative Regulation Of Mitotic Cell Cycle
Histone H3R8 Methyltransferase Activity
Protein Metabolic Process
Interleukin-5 Receptor Complex
Negative Regulation Of Helicase Activity
Negative Regulation Of G1 To G0 Transition
Macromolecule Metabolic Process
Macromolecule Catabolic Process
Positive Regulation Of DNA-templated Transcription Initiation
Cellular Response To Xenobiotic Stimulus
Response To Vitamin B2
C/EBP Complex
Negative Regulation Of Cell Cycle G1/S Phase Transition
Negative Regulation Of Cell Cycle Process
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Nuclear Progesterone Receptor Binding
Mitotic DNA Integrity Checkpoint Signaling
Synaptonemal Complex Disassembly
Golgi Inheritance
Mitotic DNA Damage Checkpoint Signaling
Protein Catabolic Process
Interleukin-5 Receptor Binding
Oligodendrocyte Apoptotic Process
Negative Regulation Of Pentose-phosphate Shunt
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