SDCBP and SIAH1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		SDCBP	SIAH1
Gene Name		syndecan binding protein (syntenin)	siah E3 ubiquitin protein ligase 1
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Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Plasma Membrane Interleukin-5 Receptor Complex Adherens Junction Focal Adhesion Membrane Vesicle Melanosome Extracellular Vesicular Exosome Blood Microparticle	Nucleus Cytoplasm Early Endosome Cytosol Plasma Membrane Beta-catenin Destruction Complex
	Molecular Function	Glycoprotein Binding Frizzled Binding Interleukin-5 Receptor Binding Protein Binding Protein C-terminus Binding Cytoskeletal Adaptor Activity Growth Factor Binding Neurexin Family Protein Binding Identical Protein Binding Protein Homodimerization Activity Syndecan Binding Ephrin Receptor Binding Protein Heterodimerization Activity Protein N-terminus Binding Cell Adhesion Molecule Binding	Ubiquitin-protein Transferase Activity Protein Binding Protein C-terminus Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Activity
	Biological Process	Protein Targeting To Membrane Substrate-dependent Cell Migration, Cell Extension Ras Protein Signal Transduction Synaptic Transmission Axon Guidance Actin Cytoskeleton Organization Intracellular Signal Transduction Positive Regulation Of Phosphorylation Positive Regulation Of JNK Cascade Ephrin Receptor Signaling Pathway Positive Regulation Of Exosomal Secretion Positive Regulation Of Extracellular Vesicular Exosome Assembly	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Cell Cycle Spermatogenesis Nervous System Development Axon Guidance Anatomical Structure Morphogenesis Protein Catabolic Process Protein Destabilization Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Neuron Apoptotic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Ephrin signaling Axon guidance Neurofascin interactions EPH-Ephrin signaling L1CAM interactions	Axon guidance Netrin-1 signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		167 interactors: ABI2 AES ANKRD40 ANP32B APIP BCL2L15 C11orf57 C11orf68 C1orf109 CADM1 CADPS CALCOCO2 CBR3 CCDC102B CCDC36 CCDC53 CD6 CD63 CDA CDC34 CDCP1 CDIPT CEP55 CGGBP1 CLK2 CLK3 CMTM5 COX4I1 CRYAA CT45A3 CT45A5 CUTC DAK DCTD DCTPP1 DMC1 DTNBP1 EAF1 EDARADD EFNB1 EFNB2 EIF1AD EIF5A2 ELAVL1 ENOX1 EPHB2 ERICH2 FAM118A FAM118B FAM9B FLAD1 FOXP2 FTH1 FTL GNMT GPATCH11 GPR37 GRIA1 GRIA2 GRIA3 GRIA4 GRIK1 GRIK2 GRIK3 GRM3 HIVEP1 HMGB3 HNRNPC HOMEZ HOXA1 HPRT1 HSBP1 IKZF1 IL5RA INO80E KCNH1 KCTD1 KCTD6 KCTD9 KHDRBS2 KLHL12 KLHL2 KRTAP10-3 KRTAP10-7 KRTAP5-9 LDOC1 LGALS2 LSM6 LZTFL1 MAD2L1 MAPRE3 MBD3 MED4 MID2 MRFAP1L1 MTUS2 NADK NAGK NECAB2 NF2 NFASC NOTCH2NL NT5C2 OSTF1 PDCD6IP PDE4DIP PHC2 PNMA1 PNMA2 PRPF38A PRPF40A PRR13 PSMC6 PSTPIP1 PTPRJ PTS PUF60 PYCRL RAB5A RBM39 REEP6 REL RIC8A RNF11 RNH1 ROPN1 RP9P RTN1 RUNDC3A SDC1 SDC2 SDC4 SDCBP2 SDCCAG3 SEPT3 SET SIAH1 SLC6A5 SMARCA2 SOX4 SREK1IP1 SRSF11 SRSF7 SSNA1 STX1A SULT1B1 TDO2 TEKT1 TFCP2 TGFA THG1L TIFA TMEM239 TNFAIP8 TRAF5 TRIM27 TRIM32 TRIM38 TRIM54 UBE2A ULK1 WASL WDR91 ZBTB14 ZBTB8A ZCCHC10 ZCCHC17	135 interactors: AASDHPPT AFF1 AFF4 APC AQP1 ARMC9 ATN1 ATXN7 BAG1 BCL6 C14orf105 CACYBP CAPG CDC23 CDC34 CDK5R1 CTNNB1 DAB1 DCC DDX41 DNAJC15 DNALI1 EEF1D EIF3J ELL2 EXOC3-AS1 FAM90A1 FLI1 FZD9 GAPDH GDPD5 GRM5 HIPK2 HIPK3 HIST4H4 INHA KATNAL1 KCNJ10 KHDRBS3 KIAA0319L KIAA1217 KIAA1683 KIF1B KIF22 KIFC3 LACTB2 MAB21L1 MAPK12 MAPKBP1 MAPRE3 MOB3C MTIF3 MX1 MYD88 NELFA NOL6 NUMB NUMBL OPRM1 OTUB2 PEG10 PEG3 PFKM PHC1 PHC2 PIAS1 PIAS2 PIAS3 PKD1 POU2AF1 PRPF31 PRR20A PTPMT1 PUF60 PVRL2 PYGB QRICH1 RAB33A RAD51AP1 RAD54L2 RAPH1 RBBP8 RPL27A RPS19BP1 SDCBP SH3RF1 SLC9A3R2 SNCA SNCAIP SPATA4 SPATC1L STAT3 SYP SYT7 TBC1D22B TERF2 TFDP1 TMEM43 TNK2 TOLLIP TP53BP2 TRIM23 TRIM27 TRIM7 TRIM8 TUBA1A TUBA1B TUBA3C TUBA4A TUBA8 TXN UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E3 UBE2I UBE2K UBE2L6 UBE2N UBE2V2 UPP2 USP19 UXT VAV1 WDYHV1 ZBP1 ZCCHC10 ZCCHC13 ZFYVE21 ZMAT3 ZNF148 ZNF512B ZNF671
Entrez ID		6386	6477
HPRD ID		03741	03736
Ensembl ID		ENSG00000137575	ENSG00000196470
Uniprot IDs		B4DHN5 G5EA09 O00560	Q8IUQ4
PDB IDs		1N99 1NTE 1OBX 1OBY 1OBZ 1R6J 1V1T 1W9E 1W9O 1W9Q 1YBO	2A25 4I7B 4I7C 4I7D
Enriched GO Terms of Interacting Partners?		Glutamate Receptor Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Neuron-neuron Synaptic Transmission Positive Regulation Of Extracellular Vesicular Exosome Assembly Regulation Of Cellular Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Extracellular Vesicular Exosome Assembly Synaptic Transmission Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Protein Homooligomerization Positive Regulation Of Exocytosis Protein Tetramerization Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Cellular Metabolic Process Regulation Of Cellular Component Organization Protein Oligomerization Protein Homotetramerization Negative Regulation Of Synaptic Transmission, Glutamatergic Response To Stimulus Cell-cell Signaling Regulation Of Synaptic Transmission Cellular Process Protein Complex Assembly Positive Regulation Of Cellular Component Biogenesis Negative Regulation Of Viral Release From Host Cell Gene Expression Positive Regulation Of Secretion Protein Ubiquitination Negative Regulation Of Cellular Metabolic Process RNA Splicing Protein Modification By Small Protein Conjugation Positive Regulation Of Dopamine Metabolic Process Negative Regulation Of Biosynthetic Process Transcription, DNA-templated Ephrin Receptor Signaling Pathway Regulation Of Exocytosis Negative Regulation Of Viral Transcription Regulation Of Viral Release From Host Cell Nucleoside Metabolic Process Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Organelle Assembly Negative Regulation Of Synaptic Transmission RNA Biosynthetic Process Regulation Of Synaptic Transmission, Glutamatergic Protein Polyubiquitination	Protein Modification By Small Protein Conjugation Apoptotic Process Programmed Cell Death Cell Death Death Protein Polyubiquitination Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Innate Immune Response Protein Ubiquitination Protein K48-linked Ubiquitination Regulation Of Signaling Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Process Negative Regulation Of Cellular Metabolic Process Defense Response Cellular Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Signal Transduction Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Immune Response Regulation Of RNA Metabolic Process Response To Stress Positive Regulation Of Protein Metabolic Process Cellular Response To Stimulus Immune System Process Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process RNA Biosynthetic Process Positive Regulation Of Cellular Protein Metabolic Process Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Metabolic Process Cellular Response To Stress Cellular Response To Organic Substance Response To Cytokine Response To Organic Substance Negative Regulation Of Gene Expression Regulation Of Cell Death Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Response To Stimulus Regulation Of Chromosome Organization
Tagcloud ?		conversely datasets fak healing hepatocyte hgf il2rgamma immunofluorescence indication lethality matrigel mda melanoma melanomas metastases metastasizes metastatic migrate opposite pseudo scid syndecan syndecans syntenin triggered unrelated uveal warrants wound	alleviates anticancer appears cytotoxicity debatable decreases degradation demonstrating downregulation e3 exerts increases inducing inhibiting introduce ligase note oncoprotein p34sei partly polyubiquitination prerequisite previous reveal stronger summary ubiquitin view vitamin
Tagcloud (Difference) ?		conversely datasets fak healing hepatocyte hgf il2rgamma immunofluorescence indication lethality matrigel mda melanoma melanomas metastases metastasizes metastatic migrate opposite pseudo scid syndecan syndecans syntenin triggered unrelated uveal warrants wound	alleviates anticancer appears cytotoxicity debatable decreases degradation demonstrating downregulation e3 exerts increases inducing inhibiting introduce ligase note oncoprotein p34sei partly polyubiquitination prerequisite previous reveal stronger summary ubiquitin view vitamin
Tagcloud (Intersection) ?