SDCBP and FHL3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SDCBP	FHL3
Description		syndecan binding protein	four and a half LIM domains 3
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Plasma Membrane Interleukin-5 Receptor Complex Adherens Junction Focal Adhesion Membrane Nuclear Membrane Azurophil Granule Lumen Melanosome Membrane Raft Synapse Extracellular Exosome Anchoring Junction Blood Microparticle Extracellular Vesicle	Stress Fiber Nucleus Cytoplasm Focal Adhesion Z Disc
	Molecular Function	Frizzled Binding Interleukin-5 Receptor Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Cytoskeletal Anchor Activity Lipid Binding Identical Protein Binding Syndecan Binding Protein Heterodimerization Activity Protein Sequestering Activity	Transcription Coregulator Activity Actin Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Receptor Internalization Protein Targeting To Membrane Substrate-dependent Cell Migration, Cell Extension Ras Protein Signal Transduction Chemical Synaptic Transmission Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Population Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Actin Cytoskeleton Organization Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Phosphorylation Positive Regulation Of JNK Cascade Positive Regulation Of Exosomal Secretion Positive Regulation Of Extracellular Exosome Assembly	Muscle Organ Development Actin Cytoskeleton Organization
Pathways		Ephrin signaling Neurofascin interactions RIPK1-mediated regulated necrosis Regulation of necroptotic cell death Neutrophil degranulation
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Fasting insulin ( 34074324) Low density lipoprotein cholesterol levels ( 32154731) Lymphocyte count ( 32888494) Monocyte count ( 32888494) Triglyceride levels ( 32154731)	Coronary artery disease ( 29212778 33020668) Pulse pressure ( 30578418)
Interacting Genes		308 interacting genes: - ABI2 AIRIM ANKRD33 ANKRD36B ANKRD40 ANP32B APIP ARFIP2 ARL6IP1 BCL2L15 BEND7 C11orf68 C1orf35 C2CD2L CABP5 CADM1 CADPS CALCOCO2 CALM1 CALM2 CALM3 CAV2 CBR3 CBY2 CCDC102B CCDC106 CD6 CD63 CDA CDC34 CDCP1 CDIPT CDKN2D CEP55 CEP85 CGGBP1 CHIC2 CHMP1A CLK2 CLK3 CMTM5 COX4I1 CRX CRYAA CT45A1 CT45A10 CT45A3 CT45A5 CTBP2 CTDSP1 CUTC DCTD DCTPP1 DDX39B DERL3 DMC1 DNM2 DRAP1 DTNBP1 DYNLT1 EAF1 EDARADD EFNB1 EFNB2 EIF1AD EIF5A EIF5A2 ELAVL1 EMILIN3 ENOX1 ENTR1 EPHB2 ERICH2 EXOSC4 FADD FAM118A FAM118B FAM9A FAM9B FHL3 FHL5 FLAD1 FOXP2 FTH1 FTL GET4 GGPS1 GKAP1 GNMT GOLT1B GPATCH11 GPR37 GRIA1 GRIA2 GRIA3 GRIA4 GRIK1 GRIK2 GRM2 GRM3 GRM7 GRXCR1 GSC2 GSG1 HEXIM2 HHAT HIVEP1 HMBOX1 HMGB3 HNRNPC HOMER3 HOMEZ HOXA1 HOXA7 HPRT1 HSBP1 HSF2BP HUS1 ID3 IGFBP6 IHO1 IKZF1 IL5RA INO80E KATNBL1 KCNH1 KCNJ2 KCTD1 KCTD6 KCTD9 KHDRBS2 KLHL12 KLHL2 KRT14 KRTAP1-3 KRTAP1-5 KRTAP10-3 KRTAP10-7 KRTAP5-9 LCOR LDB2 LDHB LDOC1 LEPROTL1 LGALS2 LSM6 LURAP1L LZTFL1 MAD2L1 MAPK9 MAPRE3 MATN4 MBD3 MED4 MEOX1 MEOX2 MGLL MID2 MINDY3 MKRN1 MOBP MRFAP1 MRFAP1L1 MTUS2 MYBPC2 MYLIP N4BP3 NADK NAGK NAPB NECAB2 NF2 NFASC NKAPD1 NOTCH2NLA NT5C2 OCM ODAM OPTN OSTF1 PCBD1 PCYT1A PDCD6IP PDE4DIP PDE9A PDLIM4 PDZK1IP1 PFDN5 PHC2 PHF11 PIH1D2 PNMA1 PNMA2 POLR2J POLR3K PPARA PRPF38A PRPF40A PRR13 PSMB3 PSMC6 PSTPIP1 PTEN PTPRJ PTS PUF60 PYCR3 RAB5A RALY RBM39 REEP6 REL RIC8A RNF11 RNH1 ROPN1 RP9 RP9P RPIA RPL22 RPRD1A RPRM RPS26 RRM2 RRS1 RTL8B RTN1 RUNDC3A S100B SCG3 SCML1 SDC1 SDC2 SDC4 SDCBP2 SEPTIN1 SEPTIN3 SET SFT2D1 SIAH1 SLC50A1 SLC6A5 SMARCA2 SNRPA SNX1 SOX4 SPANXN3 SREK1IP1 SRSF11 SRSF3 SRSF7 SSC5D SSNA1 STX1A SUB1 SULT1B1 SYNGR1 SYPL1 SYS1 TCF21 TCF4 TDO2 TEKT1 TFCP2 TGFA THG1L TIFA TKFC TLE5 TMCO2 TMEM17 TMEM239 TNFAIP8 TNFAIP8L3 TNKS TRAF5 TRARG1 TRIM27 TRIM32 TRIM38 TRIM54 TRIP13 TSN UBB UBC UBE2A UBE2K UBE2R2 ULK1 WASHC1 WASHC3 WASL WDR91 YAP1 YIF1A ZBTB14 ZBTB8A ZCCHC10 ZCCHC17 ZFTRAF1 ZMYND12 ZNF343 ZNF485 ZNF660 ZNF768 ZRANB1 ZSCAN23	181 interacting genes: A1CF ACTB ADAM15 ADAMTSL4 AIMP2 AMBP ANKHD1 ARHGEF10 ARID5A ASCL4 BARX2 C1orf94 CASS4 CBX8 CCDC198 CCND3 CDC25B CDC42EP1 CDKN1A CDKN2D CHEK2 CIMAP1B CLCN2 CNNM3 CNOT7 CORO1A CREB5 CRIP3 CRYBA2 CSF1 CTBP2 CYSRT1 DCDC2B DLGAP4 DMRT3 DUX4L9 E2F8 EFCAB12 EIF4EBP2 EPHA10 EPM2AIP1 ERBB3 EXOSC1 EXOSC5 FADS6 FAM110A FAM222B FAM90A1 FBXL18 FHL2 FOS FOSL2 FOXN4 GARIN6 GATA1 GATA2 GCM2 GUCD1 HAPLN2 HIPK1 HOXA1 HSF2BP HYAL2 HYCC1 IHO1 IKZF3 ITGA7 ITGB5 KANK2 KIDINS220 KIRREL2 KLF12 KLF3 KLF8 KPRP KRTAP12-1 KRTAP12-2 KTI12 LASP1 LATS2 LHB LMO2 LMO4 LNX1 LNX2 MAPK1 MED15 MMP14 MORF4L1 MPZL1 MRM3 MRPL27 MRRF MSRB3 MTA1 MTUS2 MYBPC1 MYBPHL MYCBP2 MYOZ3 MYPOP MZF1 NDUFAB1 NFKBIB NPRL3 P4HA2 PAK5 PATL1 PHC2 PHF21A PIAS1 PIERCE1 PKP2 PLEKHF2 PLEKHG4B POLR1H PPIG PRR35 PRR5L PTPN6 QKI QRICH1 RAB40B RAD21 RASL12 RBM42 RFX3 RFX6 RHEBL1 RSPH14 RYBP SAP30BP SAXO1 SAXO4 SBF2 SDCBP SH3GLB2 SHE SLAIN1 SLC25A46 SLC44A3 SLU7 SMAD2 SMAD3 SMAD4 SNRPB SNRPC SNRPG SPATA8 SPMAP2 SREBF2 SRF SRGN SUPT5H TBC1D22B THAP7 TLE5 TMEM108 TMEM14B TMSB4X TMX3 TRAF3IP2 TRIM27 TRIP6 TRO TSGA10IP TTLL10 TUBA3E TYK2 TYMSOS UBE2I UBE2Q1 VWC2L WDR25 WNK1 YPEL3 ZCCHC14 ZFP36 ZNF417 ZNF512B ZNF587
Entrez ID		6386	2275
HPRD ID		03741	09101
Ensembl ID		ENSG00000137575	ENSG00000183386
Uniprot IDs		B4DHN5 G5EA09 O00560	Q13643 Q96C98
PDB IDs		1N99 1NTE 1OBX 1OBY 1OBZ 1R6J 1V1T 1W9E 1W9O 1W9Q 1YBO 4Z33 6R9H 6RLC 7FSG 7FSH 7FSI 7FSJ 7FSK 7FSL 7FSM 7FSN 7FSO 7FSP 7FSQ 7FSR 7FSS 7FST 7FSU 7FSV 7FSW 7FSX 7FSY 7FSZ 7FT0 7FT1 7FT2 7FT3 7FT4 7FT5 7FT6 7FT7 7FT8 7FT9 7FTA 7FTB 7FTC 7FTD 8AAI 8AAK 8AAO 8AAP 8BLU 8BLV 8HCK	1WYH 2CUQ 2EHE
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Protein Binding Glutamate-gated Receptor Activity Glutamate Receptor Signaling Pathway AMPA Glutamate Receptor Activity Nucleus Glutamate-gated Calcium Ion Channel Activity Synaptic Transmission, Glutamatergic Ionotropic Glutamate Receptor Signaling Pathway Cytosol Postsynaptic Membrane Ligand-gated Monoatomic Ion Channel Activity Positive Regulation Of Extracellular Exosome Assembly Regulation Of Actin Nucleation Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Positive Regulation Of Synaptic Transmission Endocytic Vesicle Membrane Protein Homooligomerization Protein Complex Oligomerization Asymmetric Synapse Protein Tetramerization Glutamate Receptor Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Nucleoplasm Dendritic Spine Ligand-gated Ion Channel Signaling Pathway Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Modulation Of Chemical Synaptic Transmission Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Extracellular Exosome Assembly Postsynaptic Density Membrane Protein Homotetramerization Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential G Protein-coupled Glutamate Receptor Signaling Pathway Presynaptic Membrane Ferric Iron Binding Phosphatidylinositol 3-kinase Inhibitor Activity Female Meiosis I Calcium Channel Regulator Activity Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Membrane Tubulation Ferritin Complex Group II Metabotropic Glutamate Receptor Activity Regulation Of Synaptic Plasticity Regulation Of Synaptic Transmission, Glutamatergic Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Long-term Synaptic Potentiation	Protein Binding Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Ventral Spinal Cord Interneuron Differentiation Negative Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Gene Expression Positive Regulation Of RNA Metabolic Process Transcription Regulator Complex Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Chromatin Binding Positive Regulation Of Biosynthetic Process Regulation Of MiRNA Metabolic Process Transcription Coregulator Binding DNA-binding Transcription Factor Activity Regulation Of Primary Metabolic Process DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of MiRNA Transcription Phosphatase Binding Positive Regulation Of Macromolecule Metabolic Process Cell Population Proliferation Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of MiRNA Transcription Identical Protein Binding SMAD Protein Complex Sequence-specific Double-stranded DNA Binding Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Chromatin Positive Regulation Of MiRNA Metabolic Process Heteromeric SMAD Protein Complex Myelination DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Axon Ensheathment
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