TFAP2B and MCM3

Data Source: HiPPIP (Novel)

		TFAP2B	MCM3
Name		transcription factor AP-2 beta	minichromosome maintenance complex component 3
Structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Chromosome, Telomeric Region Nucleus Nucleoplasm Alpha DNA Polymerase:primase Complex Chromosome Nucleolus Cytoplasm Membrane MCM Complex Perinuclear Region Of Cytoplasm CMG Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding	Nucleotide Binding DNA Binding Single-stranded DNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Single-stranded DNA Helicase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Kidney Development Glucose Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Nervous System Development Sensory Organ Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Gene Expression Retina Layer Formation Regulation Of BMP Signaling Pathway Forelimb Morphogenesis Hindlimb Morphogenesis Aorta Morphogenesis Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Skin Development Fat Cell Differentiation Regulation Of Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Sympathetic Nervous System Development Smooth Muscle Tissue Development Regulation Of Insulin Secretion Neuron Apoptotic Process Distal Tubule Development Collecting Duct Development Metanephric Nephron Development Ductus Arteriosus Closure	Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication Regulation Of DNA-templated DNA Replication Initiation Mitotic DNA Replication Initiation
Pathways		SUMOylation of transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors Activation of the TFAP2 (AP-2) family of transcription factors TFAP2 (AP-2) family regulates transcription of growth factors and their receptors Specification of the neural plate border Specification of the neural plate border	Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state
Diseases		Char syndrome	None
GWAS		Adiposity ( 19557161 ) Adult body size ( 32376654 ) Age at adiposity rebound ( 31840077 ) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 ) Bipolar disorder ( 31043756 ) Bipolar I disorder ( 31043756 ) Blood urea nitrogen levels ( 31152163 29403010 ) BMI (adjusted for smoking behaviour) ( 28443625 ) BMI in non-smokers ( 28443625 ) BMI in smokers ( 28443625 ) Body fat distribution (arm fat ratio) ( 30664634 ) Body mass index ( 31453325 29381148 28892062 20935630 28448500 24861553 26961502 23563607 25673413 ) Body mass index (adult) ( 28430825 ) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500 ) Body mass index (joint analysis main effects and smoking interaction) ( 28443625 ) Body mass index in physically active individuals ( 28448500 ) Body mass index in physically inactive individuals ( 28448500 ) Body mass index variance ( 31453325 ) Body size at age 10 ( 32376654 ) Childhood body mass index ( 33045005 26604143 ) Chronotype ( 30696823 ) Fruit consumption ( 32066663 ) Glaucoma (primary open-angle) ( 33627673 ) Hand grip strength ( 29691431 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Hip circumference ( 31453325 25673412 ) Hip circumference variance ( 31453325 ) Intraocular pressure ( 29617998 ) Keratoconus ( 33649486 ) Medication use (agents acting on the renin-angiotensin system) ( 31015401 ) Medication use (drugs used in diabetes) ( 31015401 ) Metabolic syndrome (bivariate traits) ( 21386085 ) Myopia ( 27182965 ) Nevus count or cutaneous melanoma ( 32341527 ) Obese vs. thin ( 30677029 ) Obesity ( 23563607 ) Obesity (extreme) ( 21935397 ) Refractive error ( 32231278 ) Renal function-related traits (BUN) ( 22797727 ) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814 ) Smoking status (ever vs never smokers) ( 30643258 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 ) Type 2 diabetes ( 30054458 32499647 30297969 ) Urolithiasis ( 30975718 ) Waist circumference ( 25673412 31453325 ) Waist circumference variance ( 31453325 ) Waist-hip ratio ( 25673412 ) Walking pace ( 33128006 )	Cryptococcosis in HIV infection ( 33269293 )
Novel Interactors		4 novel interactors: HCRTR2 MCM3 NDRG1 VEGFA	1 novel interactors: TFAP2B
Interacting Genes		12 interacting genes: AURKA CITED1 CITED2 CITED4 H2AC6 LZTR1 MYC SSBP4 SYT4 UBE2I VPS11 YEATS4	37 interacting genes: ATRIP CCNE1 CDC45 CDC5L CDC6 CDC7 CDK2 CSNK2A1 DBF4 EP300 FILNC1 HAUS1 LZTR1 MAPK6 MCM10 MCM2 MCM3AP MCM4 MCM5 MCM6 MCM7 MCMBP ORC2 ORC4 ORC5 PLK1 POLR2A PPP2R1A PPP2R1B PTEN RAD52 STAT1 SUMO2 SUPT16H SYF2 TRIM28 YWHAQ
Entrez ID		7021	4172
HPRD ID		03360	04072
Ensembl ID		ENSG00000008196	ENSG00000112118
Uniprot IDs		Q92481	A0A0S2Z492 A0A0S2Z4T1 A0A499FHX9 B4DUQ9 J3KQ69 P25205
PDB IDs		8J0Q	6XTX 6XTY 7PFO 7PLO 7W1Y 7W68 8B9D 8RWV 8S09 8S0A 8S0B 8S0D 8S0E 8S0F 8W0E 8W0F 8W0G 8W0I 9CAQ
GO Terms Enriched among Interactors		Regulation Of Kidney Development Cellular Response To Decreased Oxygen Levels Cellular Response To Hypoxia Cellular Response To Oxygen Levels LBD Domain Binding Perinuclear Region Of Cytoplasm Response To Estrogen Vasculogenesis Positive Regulation Of Reproductive Process Tube Morphogenesis Response To Hypoxia Response To Decreased Oxygen Levels Response To Growth Factor Branching Morphogenesis Of An Epithelial Tube Morphogenesis Of An Epithelium Response To Oxygen Levels Molecular Function Activator Activity Morphogenesis Of A Branching Structure Morphogenesis Of A Branching Epithelium Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of DNA-templated Transcription Tissue Morphogenesis Nucleoplasm Regulation Of DNA Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Branching Involved In Ureteric Bud Morphogenesis Pigmentation Negative Regulation Of Apoptotic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Acinar Cell Proliferation Regulation Of Cell Division Transcription Coregulator Binding Positive Regulation Of Acinar Cell Proliferation SCF Ubiquitin Ligase Complex Binding Regulation Of Reproductive Process Positive Regulation Of Dense Core Granule Exocytosis Negative Regulation Of Retrograde Trans-synaptic Signaling By Neuropeptide Regulation Of Postsynaptic Dense Core Vesicle Exocytosis Negative Regulation Of Short-term Neuronal Synaptic Plasticity SUMO Conjugating Enzyme Activity VEGF-A Complex Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Basophil Chemotaxis Regulation Of Primary Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Metabolic Process Regulation Of Apoptotic Process	DNA Replication Initiation DNA Metabolic Process DNA Replication Nucleic Acid Metabolic Process DNA Replication Origin Binding Double-strand Break Repair Via Break-induced Replication Nucleobase-containing Compound Metabolic Process Nucleoplasm DNA Damage Response CMG Complex MCM Complex Regulation Of DNA Metabolic Process Regulation Of DNA Replication DNA Repair Double-strand Break Repair Via Homologous Recombination Recombinational Repair Regulation Of DNA-templated DNA Replication Initiation Macromolecule Metabolic Process Nucleus Double-strand Break Repair DNA Recombination Single-stranded DNA Binding Regulation Of Cell Cycle Phase Transition Chromosome, Telomeric Region Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Stress Chromosome Negative Regulation Of Cell Cycle Phase Transition Nuclear Origin Of Replication Recognition Complex Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Single-stranded DNA Helicase Activity DNA Damage Checkpoint Signaling Origin Recognition Complex Regulation Of Cell Cycle Regulation Of Primary Metabolic Process Signal Transduction In Response To DNA Damage DNA Helicase Activity Response To Stress Sister Chromatid Cohesion Prp19 Complex Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA-templated DNA Replication ATP Binding Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Helicase Activity Cyclin E1-CDK2 Complex