TFAP2B and HCRTR2

Data Source: HiPPIP (Novel)

		TFAP2B	HCRTR2
Name		transcription factor AP-2 beta	hypocretin receptor 2
Structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Nucleoplasm Plasma Membrane Membrane Synapse
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding	G Protein-coupled Receptor Activity Protein Binding Neuropeptide Receptor Activity Orexin Receptor Activity Peptide Hormone Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Kidney Development Glucose Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Nervous System Development Sensory Organ Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Gene Expression Retina Layer Formation Regulation Of BMP Signaling Pathway Forelimb Morphogenesis Hindlimb Morphogenesis Aorta Morphogenesis Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Skin Development Fat Cell Differentiation Regulation Of Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Sympathetic Nervous System Development Smooth Muscle Tissue Development Regulation Of Insulin Secretion Neuron Apoptotic Process Distal Tubule Development Collecting Duct Development Metanephric Nephron Development Ductus Arteriosus Closure	Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Chemical Synaptic Transmission Feeding Behavior Regulation Of Circadian Sleep/wake Cycle, Wakefulness Circadian Sleep/wake Cycle Process Cellular Response To Hormone Stimulus Locomotion Regulation Of Cytosolic Calcium Ion Concentration
Pathways		SUMOylation of transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors Activation of the TFAP2 (AP-2) family of transcription factors TFAP2 (AP-2) family regulates transcription of growth factors and their receptors Specification of the neural plate border Specification of the neural plate border	Orexin and neuropeptides FF and QRFP bind to their respective receptors G alpha (q) signalling events
Drugs		None	Suvorexant Lemborexant Daridorexant
Diseases		Char syndrome	None
GWAS		Adiposity ( 19557161 ) Adult body size ( 32376654 ) Age at adiposity rebound ( 31840077 ) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 ) Bipolar disorder ( 31043756 ) Bipolar I disorder ( 31043756 ) Blood urea nitrogen levels ( 31152163 29403010 ) BMI (adjusted for smoking behaviour) ( 28443625 ) BMI in non-smokers ( 28443625 ) BMI in smokers ( 28443625 ) Body fat distribution (arm fat ratio) ( 30664634 ) Body mass index ( 31453325 29381148 28892062 20935630 28448500 24861553 26961502 23563607 25673413 ) Body mass index (adult) ( 28430825 ) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500 ) Body mass index (joint analysis main effects and smoking interaction) ( 28443625 ) Body mass index in physically active individuals ( 28448500 ) Body mass index in physically inactive individuals ( 28448500 ) Body mass index variance ( 31453325 ) Body size at age 10 ( 32376654 ) Childhood body mass index ( 33045005 26604143 ) Chronotype ( 30696823 ) Fruit consumption ( 32066663 ) Glaucoma (primary open-angle) ( 33627673 ) Hand grip strength ( 29691431 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Hip circumference ( 31453325 25673412 ) Hip circumference variance ( 31453325 ) Intraocular pressure ( 29617998 ) Keratoconus ( 33649486 ) Medication use (agents acting on the renin-angiotensin system) ( 31015401 ) Medication use (drugs used in diabetes) ( 31015401 ) Metabolic syndrome (bivariate traits) ( 21386085 ) Myopia ( 27182965 ) Nevus count or cutaneous melanoma ( 32341527 ) Obese vs. thin ( 30677029 ) Obesity ( 23563607 ) Obesity (extreme) ( 21935397 ) Refractive error ( 32231278 ) Renal function-related traits (BUN) ( 22797727 ) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814 ) Smoking status (ever vs never smokers) ( 30643258 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 ) Type 2 diabetes ( 30054458 32499647 30297969 ) Urolithiasis ( 30975718 ) Waist circumference ( 25673412 31453325 ) Waist circumference variance ( 31453325 ) Waist-hip ratio ( 25673412 ) Walking pace ( 33128006 )	Age at first sexual intercourse ( 34211149 ) Blood urea nitrogen levels ( 31152163 ) Chronotype ( 27494321 30696823 ) Daytime nap ( 33568662 ) Excessive daytime sleepiness ( 27992416 ) Fasting glucose change (long-term) ( 31263163 ) HIV-1 control ( 20041166 ) Menarche (age at onset) ( 25231870 ) Morning person ( 30696823 ) Morning vs. evening chronotype ( 26835600 27494321 ) Severity of nausea and vomiting of pregnancy ( 29563502 ) Sleep duration (short sleep) ( 30846698 ) Sleep traits (multi-trait analysis) ( 27992416 )
Novel Interactors		4 novel interactors: HCRTR2 MCM3 NDRG1 VEGFA	1 novel interactors: TFAP2B
Interacting Genes		12 interacting genes: AURKA CITED1 CITED2 CITED4 H2AC6 LZTR1 MYC SSBP4 SYT4 UBE2I VPS11 YEATS4	2 interacting genes: CD200 HCRT
Entrez ID		7021	3062
HPRD ID		03360	08374
Ensembl ID		ENSG00000008196	ENSG00000137252
Uniprot IDs		Q92481	O43614 S4X0W3
PDB IDs		8J0Q	4S0V 5WQC 5WS3 6TPG 6TPJ 6TPN 7L1U 7L1V 7SQO 7SR8 7XRR
GO Terms Enriched among Interactors		Regulation Of Kidney Development Cellular Response To Decreased Oxygen Levels Cellular Response To Hypoxia Cellular Response To Oxygen Levels LBD Domain Binding Perinuclear Region Of Cytoplasm Response To Estrogen Vasculogenesis Positive Regulation Of Reproductive Process Tube Morphogenesis Response To Hypoxia Response To Decreased Oxygen Levels Response To Growth Factor Branching Morphogenesis Of An Epithelial Tube Morphogenesis Of An Epithelium Response To Oxygen Levels Molecular Function Activator Activity Morphogenesis Of A Branching Structure Morphogenesis Of A Branching Epithelium Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of DNA-templated Transcription Tissue Morphogenesis Nucleoplasm Regulation Of DNA Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Branching Involved In Ureteric Bud Morphogenesis Pigmentation Negative Regulation Of Apoptotic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Acinar Cell Proliferation Regulation Of Cell Division Transcription Coregulator Binding Positive Regulation Of Acinar Cell Proliferation SCF Ubiquitin Ligase Complex Binding Regulation Of Reproductive Process Positive Regulation Of Dense Core Granule Exocytosis Negative Regulation Of Retrograde Trans-synaptic Signaling By Neuropeptide Regulation Of Postsynaptic Dense Core Vesicle Exocytosis Negative Regulation Of Short-term Neuronal Synaptic Plasticity SUMO Conjugating Enzyme Activity VEGF-A Complex Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Basophil Chemotaxis Regulation Of Primary Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Metabolic Process Regulation Of Apoptotic Process	Regulation Of Secretion Regulation Of Secretion By Cell Type 1 Orexin Receptor Binding Type 2 Orexin Receptor Binding Positive Regulation Of Transmission Of Nerve Impulse Neuronal Dense Core Vesicle Lumen Regulation Of Transport Negative Regulation Of Transmission Of Nerve Impulse Sleep Regulation Of Protein Secretion Protein Binding Involved In Heterotypic Cell-cell Adhesion Negative Regulation Of T Cell Migration Glycosylated Region Protein Binding Negative Regulation Of Matrix Metallopeptidase Secretion Distal Tubule Development Metanephric Nephron Development Ductus Arteriosus Closure Negative Regulation Of Transport Regulation Of Matrix Metallopeptidase Secretion Regulation Of Protein Transport Regulation Of Transmission Of Nerve Impulse Negative Regulation Of Lymphocyte Migration Regulation Of Establishment Of Protein Localization Negative Regulation Of Macrophage Migration Negative Regulation Of Macrophage Activation Negative Regulation Of Neuroinflammatory Response Nephron Development Sympathetic Nervous System Development Collecting Duct Development Negative Regulation Of Nervous System Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transforming Growth Factor Beta Production Smooth Muscle Tissue Development Nephron Tubule Development Negative Regulation Of DNA Replication Negative Regulation Of Metabolic Process Aorta Morphogenesis Renal Tubule Development Neuropeptide Hormone Activity Negative Regulation Of Potassium Ion Transport Negative Regulation Of Cell Population Proliferation Positive Regulation Of Macrophage Activation Retina Layer Formation Rough Endoplasmic Reticulum Eating Behavior Temperature Homeostasis Cell-cell Adhesion Mediator Activity Negative Regulation Of Mononuclear Cell Migration Heterotypic Cell-cell Adhesion Hindlimb Morphogenesis