OCM2 and GRM3

		OCM2	GRM3
Description		oncomodulin 2	glutamate metabotropic receptor 3
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Plasma Membrane Postsynaptic Density Membrane Axon Presynaptic Membrane Neuron Projection Dendritic Spine Postsynaptic Membrane Astrocyte Projection Glutamatergic Synapse
	Molecular Function	Calcium Ion Binding Metal Ion Binding	Group II Metabotropic Glutamate Receptor Activity G Protein-coupled Receptor Activity Calcium Channel Regulator Activity Protein Binding Glutamate Receptor Activity Scaffold Protein Binding
	Biological Process		Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Gene Expression Cellular Response To Stress Modulation Of Chemical Synaptic Transmission Regulation Of Synaptic Transmission, Glutamatergic Postsynaptic Modulation Of Chemical Synaptic Transmission
Pathways			G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)
Drugs			LY2140023
Diseases
GWAS		Regular attendance at a religious group ( 29970889) Sudden cardiac arrest ( 21658281)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Asthma ( 27611488) Autism spectrum disorder or schizophrenia ( 28540026) Brachial circumference ( 22479309) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Feeling worry ( 29500382) Hand grip strength (Mahalanobis distance) ( 32235003) LDL cholesterol levels in HIV infection ( 33109212) Neurociticism ( 29500382) Neuroticism ( 29255261) Refractive error ( 32231278) Schizophrenia ( 29483656 30285260 28991256 25056061) Seborrheic dermatitis ( 29203360) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		4 interacting genes: GSR TERF1 TERF2 TERF2IP	6 interacting genes: CALM1 GRIP1 PICK1 PPM1A SDCBP TAMALIN
Entrez ID		4951	2913
HPRD ID		01274	03070
Ensembl ID		ENSG00000135175	ENSG00000198822
Uniprot IDs		P0CE71	A4D1D0 Q14832
PDB IDs			3SM9 4XAR 5CNK 5CNM 6B7H 7WI6 7WI8 7WIH 8JCU 8JCV 8JCW 8JCX 8JCY 8JCZ 8JD0 8JD1 8JD2 8JD3 9II2 9II3
Enriched GO Terms of Interacting Partners?		Shelterin Complex Nuclear Telomere Cap Complex G-rich Strand Telomeric DNA Binding Telomere Capping RNA-templated DNA Biosynthetic Process Telomeric DNA Binding Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of DNA Recombination At Telomere Negative Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization DNA Biosynthetic Process Telomerase Activity Protection From Non-homologous End Joining At Telomere Telomere Maintenance Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Telomeric D-loop Disassembly Double-stranded Telomeric DNA Binding Telomeric Loop Disassembly Protein Localization To Chromosome, Telomeric Region Telomere Organization Negative Regulation Of DNA Metabolic Process Telomere Maintenance In Response To DNA Damage Chromosome, Telomeric Region Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase Regulation Of Chromosome Organization Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Positive Regulation Of DNA Metabolic Process Regulation Of Telomere Maintenance Via Telomerase Chromosome Organization Negative Regulation Of DNA Recombination Male Germ Cell Nucleus Regulation Of Telomere Maintenance Via Telomere Lengthening Nuclear Body Macromolecule Biosynthetic Process Glutathione-disulfide Reductase (NADPH) Activity Regulation Of DNA Metabolic Process Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Regulation Of DNA Biosynthetic Process Positive Regulation Of Shelterin Complex Assembly Positive Regulation Of Organelle Organization Telomere Cap Complex Negative Regulation Of Telomere Maintenance Via Recombination	Regulation Of Receptor-mediated Endocytosis Regulation Of Receptor Internalization Regulation Of Endocytosis Regulation Of Transport Monoamine Transport
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