TOR1AIP1 and LMNB1

Number of citations of the paper that reports this interaction (PubMedID 9305626)
36

Data Source:
HPRD (in vivo)

		TOR1AIP1	LMNB1
Description		torsin 1A interacting protein 1	lamin B1
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GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Inner Membrane Nucleoplasm Endomembrane System Membrane Nuclear Membrane	Nucleus Nuclear Envelope Nuclear Inner Membrane Lamin Filament Nuclear Lamina Nucleoplasm Intermediate Filament Membrane Nuclear Matrix Nuclear Membrane Nuclear Periphery
	Molecular Function	ATPase Activator Activity Protein Binding Lamin Binding Cytoskeletal Protein Binding ATPase Binding	Double-stranded DNA Binding Structural Constituent Of Cytoskeleton Protein Binding Phospholipase Binding Structural Constituent Of Nuclear Lamina Sequence-specific Double-stranded DNA Binding
	Biological Process	Positive Regulation Of ATP-dependent Activity Protein Localization To Nucleus Nuclear Membrane Organization Protein Localization To Nuclear Envelope	Nuclear Envelope Organization Cytoskeleton Organization Nuclear Migration Heterochromatin Formation Nuclear Pore Localization Protein Localization To Nuclear Envelope
Pathways		RHOD GTPase cycle RHOF GTPase cycle	Meiotic synapsis Formation of Senescence-Associated Heterochromatin Foci (SAHF) Nuclear Envelope Breakdown Initiation of Nuclear Envelope (NE) Reformation Breakdown of the nuclear lamina Depolymerization of the Nuclear Lamina Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation RHOD GTPase cycle RHOF GTPase cycle
Drugs
Diseases
GWAS		Refractive error ( 32231278)	Blood protein levels ( 30072576) Body fat percentage ( 31752434) Parkinson's disease (motor and cognition) ( 22658654)
Interacting Genes		8 interacting genes: CDC42 LMNA LMNB1 OGT PPP1CA PPP1CC TERF2 TERF2IP	42 interacting genes: ABCG8 ATF4 CASP3 CASP6 CCDC88B CDK1 CENPH DMAP1 FAM169A GABARAP GIT2 GZMA GZMB KPNA5 KPNA6 LBR LMNA M1AP MAP1LC3A MAP1LC3C MBIP MELK PIAS2 PIH1D2 PLEC PPP1R13B PRKCA PRKCB PRKCD PRPH PTEN RNF123 SERPINA3 SNAPIN SRPK2 SUMO4 TMPO TOR1AIP1 TP53BP2 UBE2I URB2 YWHAQ
Entrez ID		26092	4001
HPRD ID		13958	01036
Ensembl ID		ENSG00000143337	ENSG00000113368
Uniprot IDs		Q5JTV8	B4DZT3 P20700
PDB IDs		4TVS	2KPW 3JT0 3TYY 3UMN 5BNW 5VVX 7DTG
Enriched GO Terms of Interacting Partners?		Telomere Maintenance In Response To DNA Damage Organelle Organization Structural Constituent Of Nuclear Lamina Negative Regulation Of DNA Recombination At Telomere Nuclear Migration Nucleus Localization Chromosome, Telomeric Region Lamin Filament Nuclear Pore Localization Shelterin Complex Postsynapse Circadian Regulation Of Gene Expression PTW/PP1 Phosphatase Complex Protection From Non-homologous End Joining At Telomere Glutamatergic Synapse Intracellular Protein Localization Establishment Of Organelle Localization Nuclear Telomere Cap Complex G-rich Strand Telomeric DNA Binding Protein Localization To Organelle Protein Localization To Chromosome, Telomeric Region Telomere Capping Negative Regulation Of Cellular Component Organization Nuclear Lamina Telomere Maintenance Protein Localization To Nuclear Envelope Regulation Of Telomere Maintenance Chromosome Organization Telomere Organization Circadian Rhythm Nuclear Envelope Organization Entrainment Of Circadian Clock By Photoperiod Protein Phosphatase 1 Binding RNA-templated DNA Biosynthetic Process Organelle Localization Transport Along Microtubule Photoperiodism Entrainment Of Circadian Clock Telomeric DNA Binding Cytoskeleton-dependent Intracellular Transport Negative Regulation Of Telomere Maintenance Microtubule-based Transport Intracellular Transport Regulation Of Chromosome Organization Rhythmic Process Negative Regulation Of DNA Recombination Male Germ Cell Nucleus Glycogen Metabolic Process Telomere Cap Complex Negative Regulation Of Telomere Maintenance Via Recombination	Intrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Cell Death Apoptotic Process Programmed Cell Death Nuclear Membrane Organization Protein Kinase C Signaling Cellular Response To Nitrogen Starvation Intracellular Signal Transduction Mitotic Nuclear Membrane Disassembly Membrane Organization Cytoplasm Cellular Response To Chemical Stress Pyroptotic Inflammatory Response Phosphatidylethanolamine Binding Nuclear Membrane Disassembly Nuclear Inner Membrane Histone H3T6 Kinase Activity Autophagosome Maturation Membrane Disassembly Lamin Binding Nucleoplasm Diacylglycerol-dependent Serine/threonine Kinase Activity Cytosol Nuclear Envelope Response To Stress Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Response To Oxidative Stress Nucleus Regulation Of Programmed Cell Death Intracellular Signaling Cassette Cellular Response To Staurosporine SUMO Ligase Complex Regulation Of Protein Localization To Nucleus Positive Regulation Of Apoptotic Process Response To Reactive Oxygen Species Positive Regulation Of Programmed Cell Death Nucleus Organization Response To Hydrogen Peroxide Protein Maturation Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Protein Import Into Nucleus Regulation Of Endodeoxyribonuclease Activity Cardiac Muscle Cell Development Cellular Response To Oxidative Stress Cardiac Cell Development Protein Phosphorylation Protein Serine Kinase Activity
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