PTH2R and GRHPR

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		PTH2R	GRHPR
Gene Name		parathyroid hormone 2 receptor	glyoxylate reductase/hydroxypyruvate reductase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Cytoplasm Peroxisomal Matrix Cytosol Extracellular Vesicular Exosome
	Molecular Function	Parathyroid Hormone Receptor Activity	Glycerate Dehydrogenase Activity Hydroxypyruvate Reductase Activity Glyoxylate Reductase (NADP) Activity Carboxylic Acid Binding Protein Homodimerization Activity NAD Binding NADPH Binding
	Biological Process	G-protein Coupled Receptor Signaling Pathway	Excretion Metabolic Process Cellular Nitrogen Compound Metabolic Process Dicarboxylic Acid Metabolic Process Small Molecule Metabolic Process Glyoxylate Metabolic Process Protein Oligomerization Oxidation-reduction Process
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)	Glyoxylate metabolism Metabolism of amino acids and derivatives
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: CALM1 GRHPR HMG20A PTH PTH2	6 interactors: CDC7 FOS GLS2 LIG4 LSM1 PTH2R
Entrez ID		5746	9380
HPRD ID		03276	05052
Ensembl ID		ENSG00000144407	ENSG00000137106
Uniprot IDs		P49190	Q9UBQ7
PDB IDs			2GCG 2H1S 2Q50 2WWR
Enriched GO Terms of Interacting Partners?		Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Response To Fibroblast Growth Factor Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Positive Regulation Of Anoikis Regulation Of High Voltage-gated Calcium Channel Activity G-protein Coupled Receptor Signaling Pathway Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Hormone-mediated Apoptotic Signaling Pathway Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Glyoxylate Metabolic Process Negative Regulation Of Gene Expression Response To Metal Ion Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Detection Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Glycogen Biosynthetic Process Response To Parathyroid Hormone Negative Regulation Of Anoikis Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Protein Autophosphorylation Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Glycogen Catabolic Process Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Response To Inorganic Substance Negative Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Anoikis Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Cation Channel Activity Polysaccharide Catabolic Process Positive Regulation Of Monooxygenase Activity Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Rhodopsin Mediated Signaling Pathway Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Activation Of Adenylate Cyclase Activity Nitric Oxide Metabolic Process Negative Regulation Of Cellular Metabolic Process Response To Growth Factor Regulation Of Protein Autophosphorylation Reactive Nitrogen Species Metabolic Process Rhodopsin Mediated Signaling Pathway Response To Vitamin D	DNA Ligation Involved In DNA Recombination DNA-dependent DNA Replication Cellular Response To Metal Ion Double-strand Break Repair Via Break-induced Replication Cellular Response To Inorganic Substance Double-strand Break Repair Positive Regulation Of Nuclear Cell Cycle DNA Replication Lagging Strand Elongation Pro-B Cell Differentiation Conditioned Taste Aversion DNA Recombination DNA Metabolic Process Establishment Of Integrated Proviral Latency DNA Replication Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Cellular Nitrogen Compound Metabolic Process Immunoglobulin V(D)J Recombination Establishment Of Viral Latency Histone MRNA Catabolic Process T Cell Receptor V(D)J Recombination Regulation Of Nuclear Cell Cycle DNA Replication DNA Ligation Involved In DNA Repair Response To Metal Ion Lymphoid Progenitor Cell Differentiation Nitrogen Compound Metabolic Process DNA Ligation Sleep Response To Gravity Positive Regulation Of DNA-dependent DNA Replication Nucleotide-excision Repair, DNA Gap Filling Cellular Response To Lithium Ion Cellular Response To Stress Cell Division Response To Radiation Histone MRNA Metabolic Process Response To Inorganic Substance Single Strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Response To Immobilization Stress Glutamate Secretion Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Positive Regulation Of Osteoclast Differentiation Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Isotype Switching
Tagcloud ?		alters articular cdk2 cdks cfk2 cfk2r chondrocyte chondrocytes chondrocytic clones generating hypertrophic lesser localizing master metalloproteinase newborn parathyroid plate prehypertrophic presently resting restricting skeleton sox9 substantiating tip39 tuberoinfundibular
Tagcloud (Difference) ?		alters articular cdk2 cdks cfk2 cfk2r chondrocyte chondrocytes chondrocytic clones generating hypertrophic lesser localizing master metalloproteinase newborn parathyroid plate prehypertrophic presently resting restricting skeleton sox9 substantiating tip39 tuberoinfundibular
Tagcloud (Intersection) ?