PTH2R and HMG20A

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		PTH2R	HMG20A
Description		parathyroid hormone 2 receptor	high mobility group 20A
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Nucleus
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Parathyroid Hormone Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Peptide Hormone Binding	DNA Binding Protein Binding Identical Protein Binding
	Biological Process	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of Gene Expression Negative Regulation Of Protein Sumoylation Negative Regulation Of Neuron Differentiation
Pathways		Class B/2 (Secretin family receptors) G alpha (s) signalling events
Drugs		Parathyroid hormone
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Anthropometric traits ( 30576415) Hip bone mineral density and total body fat mass (bivariate analysis) ( 32963334) Metabolite levels ( 23823483) Obsessive-compulsive disorder or autism spectrum disorder ( 28641744)	Fasting glucose ( 34059833) Femur bone mineral density x serum urate levels interaction ( 34046847) Glycated hemoglobin levels ( 34059833) Hand grip strength ( 29691431) Hemoglobin A1c levels ( 29403010) Medication use (drugs used in diabetes) ( 31015401) Type 2 diabetes ( 21490949 21874001 22693455 22885922 24509480 28869590 30054458 30297969 30718926 32499647)
Interacting Genes		6 interacting genes: CALM1 DYNLT1 GRHPR HMG20A PTH PTH2	59 interacting genes: ADD1 AGR2 BACH2 BRAP C9orf72 CCDC136 CCNK CEP95 CFAP53 CREBBP DCTN4 DDIT4L DGCR6L DTNB DYRK1A FBXO7 FMNL1 FOXD4L1 FXR1 GADD45GIP1 GPSM1 GTF2A1L HPCAL1 KIFC3 KPNA2 KRT1 LMO1 LNX1 LURAP1 MAGOHB NTAQ1 NUTF2 OLIG3 PIAS2 PICK1 PSMB1 PSORS1C2 PSTPIP1 PTH2R QARS1 RAD54L2 RBM11 RBM7 RIN1 RPP30 RPRD1B RSPH9 RUSC1 SCNM1 SMAD4 SMYD1 SUOX SYTL4 TBC1D22B TCP11L1 TESC TRAF4 TRAPPC5 USHBP1
Entrez ID		5746	10363
HPRD ID		03276	16116
Ensembl ID		ENSG00000144407	ENSG00000140382
Uniprot IDs		B4DFN8 P49190	B4DMG1 Q9NP66
PDB IDs		7F16
Enriched GO Terms of Interacting Partners?		Catalytic Complex Type 1 Parathyroid Hormone Receptor Binding Parathyroid Hormone Receptor Binding Transport Of Viral Material Towards Nucleus Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus Hydroxypyruvate Reductase [NAD(P)H] Activity Hydroxypyruvate Reductase (NADH) Activity Glyoxylate Reductase (NADPH) Activity Hydroxypyruvate Reductase (NADPH) Activity Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Intracellular Transport Of Viral Protein In Host Cell Positive Regulation Of Osteoclast Proliferation Negative Regulation Of Apoptotic Process In Bone Marrow Cell Regulation Of Ryanodine-sensitive Calcium-release Channel Activity G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Hormone-mediated Apoptotic Signaling Pathway Adenylate Cyclase-activating G Protein-coupled CAMP Receptor Signaling Pathway Positive Regulation Of Cell Proliferation In Bone Marrow Negative Regulation Of Cell Differentiation Regulation Of Cell Proliferation In Bone Marrow Negative Regulation Of Bone Mineralization Involved In Bone Maturation Mitochondrion-endoplasmic Reticulum Membrane Tethering Positive Regulation Of Sequestering Of Calcium Ion Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Negative Regulation Of Voltage-gated Calcium Channel Activity Autophagosome Membrane Docking Extracellular Region Spindle Intracellular Transport Of Virus Carboxylic Acid Binding Glyoxylate Metabolic Process Negative Regulation Of Developmental Process Host Cell Secretory Vesicle Negative Regulation Of Protein Sumoylation Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Peptide Hormone Receptor Binding Positive Regulation Of Inositol Phosphate Biosynthetic Process Magnesium Ion Homeostasis Titin Binding Calcium Channel Inhibitor Activity Regulation Of Voltage-gated Calcium Channel Activity Detection Of Calcium Ion Response To Metal Ion Response To Parathyroid Hormone	Protein Binding
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