KLK15 and DYNLT1

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		KLK15	DYNLT1
Name		kallikrein related peptidase 15	dynein light chain Tctex-type 1
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Secretory Granule	Extracellular Region Cytoplasm Golgi Apparatus Spindle Cytoskeleton Cytoplasmic Dynein Complex Microtubule Cytoplasmic Microtubule Dynein Complex Secretory Granule Lumen Host Cell Secretory Vesicle Ficolin-1-rich Granule Lumen
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity	Protein Binding Identical Protein Binding Dynein Intermediate Chain Binding
	Biological Process	Proteolysis Protein Maturation	Establishment Of Mitotic Spindle Orientation Microtubule-based Movement Nervous System Development Regulation Of G Protein-coupled Receptor Signaling Pathway Intracellular Transport Of Viral Protein In Host Cell Positive Regulation Of Intracellular Transport Symbiont Entry Into Host Cell Negative Regulation Of Neurogenesis Cell Division Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus Transport Of Viral Material Towards Nucleus
Pathways		None	Neutrophil degranulation
GWAS		Celiac disease ( 23936387 ) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189 ) Prostate-specific antigen levels ( 25434496 )	No GWAS studies recorded
Novel Interactors		None recorded	7 novel interactors: ACAT2 CRHBP ERO1A PRKN RPS6KA2 SYNJ2 TMEM143
Interacting Genes		4 interacting genes: DYNLT1 HOOK2 KRTAP10-3 TRIP6	48 interacting genes: ACOX2 ACTN1 APP ARID4B BAG3 BMPR2 CCDC68 DDX54 DHX33 DNAJA2 DOC2A DOC2B DVL1 DVL2 DYNC1I1 DYNC1I2 FXR2 HAVCR1 HSPB7 HSPB9 ILF2 KIF2A KLK15 LNX1 NHSL2 NTAQ1 NUP153 NUP62 OLFM3 PELO PITX2 PSMA1 PTGES3L-AARSD1 PTH2R PVR RAD21 RBM14 RRAGA SDCBP SIRPA SVIL TCEANC TROAP TUBA3C TXN UXT VDAC1 XRN2
Entrez ID		55554	6993
HPRD ID		07490	15987
Ensembl ID		ENSG00000174562	ENSG00000146425
Uniprot IDs		A0A6B7HBY5 A0A6B7HEB8 M0R0D7 Q6UBM2 Q9H2R5	P63172
PDB IDs		Not available	5JPW 8J07 8PR0 8PR1 8PTK 8RGI
GO Terms Enriched among Interactors		Transport Of Viral Material Towards Nucleus Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus Intracellular Transport Of Viral Protein In Host Cell Host Cell Microtubule Intracellular Transport Of Virus Cytoskeleton Secretory Vesicle Protein Localization To Perinuclear Region Of Cytoplasm FHF Complex Interleukin-1 Receptor Binding HOPS Complex Microtubule Cytoskeleton Organization Cytoplasmic Dynein Complex Nuclear Thyroid Hormone Receptor Binding Focal Adhesion Assembly Early Endosome To Late Endosome Transport Dynein Light Intermediate Chain Binding	Aggresome Chemical Synaptic Transmission Frizzled Binding Trans-synaptic Signaling Synaptic Signaling Synapse PTB Domain Binding Convergent Extension Involved In Neural Plate Elongation Microtubule-based Process Outflow Tract Morphogenesis Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cytoplasm Presynapse Regulation Of JNK Cascade Amyloid Fibril Formation Convergent Extension Involved In Organogenesis Regulation Of Spontaneous Synaptic Transmission Spindle Pole Convergent Extension Involved In Gastrulation Aggresome Assembly Spontaneous Neurotransmitter Secretion Synaptic Vesicle Exocytosis Positive Regulation Of Cellular Component Organization Transport Along Microtubule Vesicle-mediated Transport In Synapse Dynein Light Chain Binding Neurotransmitter Transport Positive Regulation Of Neuron Projection Arborization Neurotransmitter Secretion Protein-folding Chaperone Binding Cellular Response To Manganese Ion Regulated Exocytosis Regulation Of Exocytosis Centriolar Subdistal Appendage Inclusion Body Assembly Cytoskeleton-dependent Intracellular Transport Negative Regulation Of Transport Apoptotic Process Hsp70 Protein Binding Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Type 2 Mitophagy Cell-cell Signaling Microtubule-based Transport Programmed Cell Death Cell Death Microtubule Convergent Extension Calcium-dependent Activation Of Synaptic Vesicle Fusion Microtubule Motor Activity Response To Manganese Ion