PIP5K1B

Name	phosphatidylinositol-4-phosphate 5-kinase type 1 beta
Structure	No pdb structure
Interactors	3 interactors: BTK PIP5KL1 SNCA
GO Annotations	Cellular Component	Uropod Cytoplasm Cytosol Plasma Membrane Endomembrane System Membrane
	Molecular Function	Nucleotide Binding 1-phosphatidylinositol-3-phosphate 5-kinase Activity Protein Binding ATP Binding Kinase Activity 1-phosphatidylinositol-4-phosphate 5-kinase Activity Transferase Activity Phosphatidylinositol Kinase Activity 1-phosphatidylinositol-5-kinase Activity
	Biological Process	Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phosphatidylinositol Metabolic Process Phosphatidylinositol Phosphate Biosynthetic Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Pathways	Synthesis of PIPs at the plasma membrane WNT mediated activation of DVL PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
GWAS	Angiotensin-converting enzyme inhibitor intolerance ( 28030426 ) Body mass index (recreational physical activity interaction) ( 23192594 ) Chronic kidney disease ( 20383146 31152163 ) Creatinine levels ( 31015462 ) Estimated glomerular filtration rate ( 30604766 31152163 31451708 ) Estimated glomerular filtration rate in diabetes ( 31451708 ) Estimated glomerular filtration rate in non-diabetics ( 31451708 ) Glomerular filtration rate ( 27588450 ) Glomerular filtration rate (creatinine) ( 26831199 28452372 ) Glomerular filtration rate in non diabetics (creatinine) ( 26831199 ) Night sleep phenotypes ( 27126917 ) Platelet distribution width ( 32888494 ) Systolic blood pressure ( 30578418 )
Entrez ID	8395
HPRD ID	04121
Ensembl ID	ENSG00000107242
Uniprot IDs	O14986 Q7KYT6
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Phospholipase Binding Regulation Of B Cell Cytokine Production Monocyte Proliferation Positive Regulation Of Interleukin-17A Production Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Type I Hypersensitivity Positive Regulation Of Inflammatory Response Cellular Response To Oxidative Stress Positive Regulation Of Endocytosis Phosphate-containing Compound Metabolic Process Eosinophil Homeostasis Positive Regulation Of Type III Hypersensitivity Positive Regulation Of Protein-containing Complex Assembly Signal Release B Cell Affinity Maturation Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Negative Regulation Of Chaperone-mediated Autophagy Positive Regulation Of Synoviocyte Proliferation Cellular Response To Molecule Of Fungal Origin Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Negative Regulation Of Dopamine Metabolic Process Regulation Of Serotonin Uptake Cellular Response To Chemical Stress Histamine Secretion By Mast Cell Response To Molecule Of Fungal Origin Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Catecholamine Metabolic Process Response To Lipopolysaccharide Regulation Of Endocytosis Dopamine Uptake Involved In Synaptic Transmission Response To Molecule Of Bacterial Origin Phospholipid Metabolic Process Histamine Secretion Positive Regulation Of Hypersensitivity Lipid Binding Response To Iron(II) Ion Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Positive Regulation Of CGAS/STING Signaling Pathway Response To Oxidative Stress Regulation Of Chaperone-mediated Autophagy Regulation Of Dopamine Uptake Involved In Synaptic Transmission