HNF1A and APAF1

		HNF1A	APAF1
Description		HNF1 homeobox A	apoptotic peptidase activating factor 1
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GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm Protein-containing Complex	Extracellular Region Nucleus Cytoplasm Cytosol Protein-containing Complex Secretory Granule Lumen Apoptosome Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Protein Dimerization Activity	Nucleotide Binding Protein Binding ATP Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Heat Shock Protein Binding Identical Protein Binding ADP Binding Cysteine-type Endopeptidase Activator Activity
	Biological Process	Liver Development Regulation Of Transcription By RNA Polymerase II Insulin Secretion Pancreas Development Regulation Of Pronephros Size Renal D-glucose Absorption Glucose Homeostasis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II D-glucose Import Positive Regulation Of Transcription Initiation By RNA Polymerase II	Response To Hypoxia Kidney Development Neural Tube Closure Apoptotic Process Nervous System Development Brain Development Response To Nutrient Cardiac Muscle Cell Apoptotic Process Cell Differentiation Forebrain Development Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process System Development Neuron Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Transforming Growth Factor Beta Stimulus Response To G1 DNA Damage Checkpoint Signaling Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic DNA Fragmentation Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Regulation of gene expression in beta cells	Formation of apoptosome Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes Neutrophil degranulation TP53 Regulates Transcription of Caspase Activators and Caspases Transcriptional Regulation by E2F6 Regulation of the apoptosome activity Regulation of the apoptosome activity
Drugs		D-norleucine	ATP
Diseases		Maturity onset diabetes of the young (MODY)
GWAS		Acute insulin response ( 28490609) Age at first birth ( 34211149) Apolipoprotein B levels ( 32203549) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Birth weight ( 31043758) Blood protein levels in cardiovascular risk ( 28369058) Blood urea nitrogen levels ( 29403010) C-reactive protein ( 18439548 18439552 19567438 21196492 21647738 22939635 23844046) C-reactive protein and white blood cell count ( 22788528) C-reactive protein levels ( 21300955 24763700 29403010 29878111 30388399 31622379 33339817) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Ceramide levels (C22:0) ( 32489964) Chloride levels ( 29403010) Cholesterol, total ( 20686565 24097068 25961943) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Coronary artery disease ( 28714974 29212778 32469254 33020668) Coronary heart disease ( 19198612) Gallstone disease ( 30504769) Gamma glutamyl transferase levels ( 22010049 29403010 33339817) Gamma glutamyl transpeptidase ( 21909109) Glucosuria ( 30476138) Glucosuria (moderate to severe) ( 30476138) HDL cholesterol levels ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Hemoglobin levels ( 32327693) High-sensitivity C-reactive protein levels in HIV infection ( 33095540) Homocysteine levels ( 23824729) Insulinogenic index ( 23263489) LDL cholesterol ( 19060906 20686565 24097068 25961943 30275531) LDL cholesterol levels ( 28334899 30698716 32203549) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Liver enzyme levels ( 18940312) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Longevity ( 20834067) Low density lipoprotein cholesterol levels ( 32154731 33339817) Myocardial infarction ( 33532862) N-glycan levels ( 21203500 21908519) Pancreatic cancer ( 26098869 29422604) Pancreatic ductal adenocarcinoma ( 30541042) Peak insulin response ( 28490609) Serum alkaline phosphatase levels ( 31666285 33339817 33547301) Serum alpha1-antitrypsin levels ( 26174136) Serum C-reactive protein concentration ( 32928877) Serum C-reactive protein concentration in high fat diet ( 32928877) Serum C-reactive protein concentration in low fat diet ( 32928877) Serum C-reactive protein concentration in non-obese individuals ( 32928877) Serum C-reactive protein concentration in obesity ( 32928877) Serum C-reactive protein concentration in visceral obesity (waist circumference) ( 32928877) Serum C-reactive protein concentration in visceral obesity (waist-hip ratio) ( 32928877) Serum metabolite levels (CMS) ( 31636271) Stroke ( 32693751) Total cholesterol levels ( 28334899 30275531) Type 2 diabetes ( 20581827 21573907 22885922 24509480 26818947 28869590 29632382 30297969 30718926 32499647) Type 2 diabetes (adjusted for BMI) ( 29632382) Urate levels ( 23263486 31578528) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)	Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172)
Interacting Genes		24 interacting genes: ALB BCR CDX2 CEBPA CREBBP CTNNB1 EP300 FOS GATA5 HNF1B HNF4A KAT2B MYOG NCOA1 NCOA3 PCBD1 POU2F1 RAC3 RNF14 RYR3 SRC STAT3 TLE1 TLE5	19 interacting genes: APIP AVEN BCL2L1 BCL2L10 CASP3 CASP4 CASP8 CASP9 CYCS FAS FEM1B HIP1 HSP90AA1 HSPA1A NLRP1 NUP107 PPP1CA TOP1 TRIAP1
Entrez ID		6927	317
HPRD ID		00800	03755
Ensembl ID		ENSG00000135100	ENSG00000120868
Uniprot IDs		A0A0A0MTK8 E0YMI7 F5H0K0 P20823	O14727
PDB IDs		1IC8 2GYP 8PI7 8PI8 8PI9 8PIA	1C15 1CWW 1CY5 1Z6T 2P1H 2YGS 3J2T 3JBT 3YGS 4RHW 5JUY 5WVC 5WVE 8XQK
Enriched GO Terms of Interacting Partners?		Transcription Regulator Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Chromatin Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Protein-lysine-acetyltransferase Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Histone Acetyltransferase Activity Negative Regulation Of RNA Metabolic Process Intracellular Signal Transduction Positive Regulation Of Metabolic Process N-terminal Peptidyl-lysine Acetylation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein-containing Complex Transcription Coactivator Activity DNA-binding Transcription Factor Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Primary Metabolic Process Regulation Of Developmental Process Response To Nutrient Levels RNA Polymerase II Transcription Regulator Complex Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Cellular Response To Nutrient Levels Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Chromatin DNA Binding Animal Organ Development Positive Regulation Of Cell Differentiation Cellular Response To Oxygen-containing Compound Sequence-specific DNA Binding Nucleus DNA-binding Transcription Factor Activity Chromatin Binding Developmental Process Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process Transcription Coregulator Binding	Cell Death Programmed Cell Death Apoptotic Process Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Apoptotic Signaling Pathway Pyroptotic Inflammatory Response Intrinsic Apoptotic Signaling Pathway Response To Anesthetic Death-inducing Signaling Complex Positive Regulation Of Pyroptotic Inflammatory Response Response To Cobalt Ion Mitochondrion Leukocyte Apoptotic Process Neuron Apoptotic Process Positive Regulation Of Apoptotic Process Death Receptor Binding Positive Regulation Of Programmed Cell Death Cysteine-type Endopeptidase Activity Nucleus Positive Regulation Of Neuron Apoptotic Process Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Apoptosome Response To Radiation Execution Phase Of Apoptosis Positive Regulation Of Defense Response Negative Regulation Of Programmed Cell Death Response To Stress Glial Cell Apoptotic Process Cytosol Inflammatory Response CD95 Death-inducing Signaling Complex NLRP1 Inflammasome Complex Extrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Epithelial Cell Apoptotic Process Regulation Of Neuron Apoptotic Process Cysteine-type Peptidase Activity Negative Regulation Of Apoptotic Process Self Proteolysis Response To UV Fibroblast Apoptotic Process Intracellular Signal Transduction Regulation Of Extrinsic Apoptotic Signaling Pathway Protein Maturation Cellular Response To Radiation Positive Regulation Of Inflammatory Response Response To Light Stimulus Interleukin-18-mediated Signaling Pathway
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