HNF1A and RYR3

Number of citations of the paper that reports this interaction (PMID 20195357)
18

Data Source:
BioGRID (pull down)

		HNF1A	RYR3
Gene Name		HNF1 homeobox A	ryanodine receptor 3
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Protein Complex	Integral Component Of Membrane Junctional Membrane Complex Sarcoplasmic Reticulum Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity Protein Dimerization Activity	Ryanodine-sensitive Calcium-release Channel Activity Calcium Ion Binding Calmodulin Binding Calcium-release Channel Activity Calcium-induced Calcium Release Activity
	Biological Process	Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Insulin Secretion Regulation Of Pronephros Size Renal Glucose Absorption Glucose Homeostasis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Glucose Import Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter	Calcium Ion Transport Striated Muscle Contraction Ion Transmembrane Transport Protein Homotetramerization Negative Regulation Of Cytosolic Calcium Ion Concentration Transmembrane Transport Calcium Ion Transmembrane Transport Cellular Response To Calcium Ion Cellular Response To Magnesium Ion Cellular Response To Caffeine Cellular Response To ATP
Pathways		Regulation of beta-cell development Regulation of gene expression in beta cells	Ion channel transport Stimuli-sensing channels
Drugs
Diseases
GWAS		C-reactive protein ( 19567438 21647738 18439548 18439552 21196492 21300955 22939635) C-reactive protein and white blood cell count ( 22788528) Cholesterol, total ( 20686565) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Coronary heart disease ( 19198612) Gamma gluatamyl transferase levels ( 22010049) Gamma glutamyl transpeptidase ( 21909109) LDL cholesterol ( 19060906 20686565) Liver enzyme levels ( 18940312) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Longevity ( 20834067) N-glycan levels ( 21203500) Type 2 diabetes ( 21573907 20581827) Urate levels ( 23263486)	Carotid atherosclerosis in HIV infection ( 20009918)
Protein-Protein Interactions		21 interactors: AES ALB BCR CDX2 CEBPA CREBBP CTNNB1 EP300 FOS GATA5 HNF1B HNF4A KAT2B PCBD1 POU2F1 RAC3 RNF14 RYR3 SRC STAT3 TLE1	3 interactors: FKBP1A HNF1A RYR2
Entrez ID		6927	6263
HPRD ID		00800	01620
Ensembl ID		ENSG00000135100	ENSG00000198838
Uniprot IDs		F5H5U3 P20823	Q15413
PDB IDs		1IC8 2GYP	4ERV
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Metabolic Process Response To Organic Substance Positive Regulation Of Cellular Metabolic Process RNA Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Cellular Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Organ Morphogenesis Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription N-terminal Peptidyl-lysine Acetylation Negative Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Response To Hormone Negative Regulation Of Gene Expression Response To Steroid Hormone Negative Regulation Of Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Anatomical Structure Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Anatomical Structure Morphogenesis Organ Development Intracellular Receptor Signaling Pathway Response To Lipid Response To Organic Cyclic Compound Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Developmental Process Nitrogen Compound Metabolic Process Multicellular Organismal Development Cell Communication System Development	Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Response To Caffeine Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Sequestering Of Calcium Ion Ventricular Cardiac Muscle Tissue Morphogenesis Calcium Ion Transport Into Cytosol Cytosolic Calcium Ion Transport Ventricular Cardiac Muscle Tissue Development Cardiac Muscle Tissue Morphogenesis Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Muscle Tissue Morphogenesis Tissue Morphogenesis Muscle Organ Morphogenesis Cardiac Ventricle Morphogenesis Regulation Of Cation Channel Activity Chemical Homeostasis Enzyme Linked Receptor Protein Signaling Pathway Cardiac Ventricle Development Organ Morphogenesis Cardiac Chamber Development Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Response To Alkaloid Left Ventricular Cardiac Muscle Tissue Morphogenesis Renal Glucose Absorption Positive Regulation Of Calcium-transporting ATPase Activity Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity By Adrenergic Receptor Signaling Pathway Involved In Positive Regulation Of Cardiac Muscle Contraction Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Ion Homeostasis Response To Purine-containing Compound Cytosolic Calcium Ion Homeostasis Cardiac Muscle Tissue Development Regulation Of Calcium Ion Transport Homeostatic Process Positive Regulation Of Sequestering Of Calcium Ion Type B Pancreatic Cell Apoptotic Process Calcium Ion Transmembrane Transport Muscle Contraction Heart Morphogenesis Negative Regulation Of Protein Phosphatase Type 2B Activity Amyloid Fibril Formation Regulation Of Calcium-transporting ATPase Activity Adrenergic Receptor Signaling Pathway Involved In Heart Process Purkinje Myocyte To Ventricular Cardiac Muscle Cell Signaling Muscle System Process Tissue Development Muscle Organ Development Ion Transport
Tagcloud ?		2x10 56x10 5x10 apaf1 birc2 casp4 cdk2 clones disruptions ductal dysregulated e2f1 enrichment g0 investigating mcm2 messenger mia micro paca panc pancreas pancreatic pdac promise rank skp2 sub uncover	adni aid alzheimer amyloidogenesis av cacna1c calcium cascade channels cohorts considerable datasets emission encode etiology focusing heterogeneity implicating inform initiative load neuroimaging oligogenic pet pib positron subsets tomography validation
Tagcloud (Difference) ?		2x10 56x10 5x10 apaf1 birc2 casp4 cdk2 clones disruptions ductal dysregulated e2f1 enrichment g0 investigating mcm2 messenger mia micro paca panc pancreas pancreatic pdac promise rank skp2 sub uncover	adni aid alzheimer amyloidogenesis av cacna1c calcium cascade channels cohorts considerable datasets emission encode etiology focusing heterogeneity implicating inform initiative load neuroimaging oligogenic pet pib positron subsets tomography validation
Tagcloud (Intersection) ?