HNF1A and GATA5

Number of citations of the paper that reports this interaction (PMID 14715527)
16

Data Source:
HPRD (in vivo, in vitro)

		HNF1A	GATA5
Gene Name		HNF1 homeobox A	GATA binding protein 5
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Protein Complex	Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity Protein Dimerization Activity	Enhancer Sequence-specific DNA Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Zinc Ion Binding Transcription Regulatory Region DNA Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Insulin Secretion Regulation Of Pronephros Size Renal Glucose Absorption Glucose Homeostasis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Glucose Import Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter	Transcription From RNA Polymerase II Promoter Blood Coagulation Positive Regulation Of Transcription From RNA Polymerase II Promoter Intestinal Epithelial Cell Differentiation Cellular Response To BMP Stimulus
Pathways		Regulation of beta-cell development Regulation of gene expression in beta cells	Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		C-reactive protein ( 19567438 21647738 18439548 18439552 21196492 21300955 22939635) C-reactive protein and white blood cell count ( 22788528) Cholesterol, total ( 20686565) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Coronary heart disease ( 19198612) Gamma gluatamyl transferase levels ( 22010049) Gamma glutamyl transpeptidase ( 21909109) LDL cholesterol ( 19060906 20686565) Liver enzyme levels ( 18940312) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Longevity ( 20834067) N-glycan levels ( 21203500) Type 2 diabetes ( 21573907 20581827) Urate levels ( 23263486)	Prostate cancer ( 23535732)
Protein-Protein Interactions		21 interactors: AES ALB BCR CDX2 CEBPA CREBBP CTNNB1 EP300 FOS GATA5 HNF1B HNF4A KAT2B PCBD1 POU2F1 RAC3 RNF14 RYR3 SRC STAT3 TLE1	3 interactors: EP300 HNF1A KLF2
Entrez ID		6927	140628
HPRD ID		00800	17029
Ensembl ID		ENSG00000135100	ENSG00000130700
Uniprot IDs		F5H5U3 P20823	D9ZGF7 Q9BWX5
PDB IDs		1IC8 2GYP
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Metabolic Process Response To Organic Substance Positive Regulation Of Cellular Metabolic Process RNA Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Cellular Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Organ Morphogenesis Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription N-terminal Peptidyl-lysine Acetylation Negative Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Response To Hormone Negative Regulation Of Gene Expression Response To Steroid Hormone Negative Regulation Of Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Anatomical Structure Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Anatomical Structure Morphogenesis Organ Development Intracellular Receptor Signaling Pathway Response To Lipid Response To Organic Cyclic Compound Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Developmental Process Nitrogen Compound Metabolic Process Multicellular Organismal Development Cell Communication System Development	Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryo Development Histone H2B Acetylation Renal Glucose Absorption Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Lung Development Respiratory Tube Development N-terminal Peptidyl-lysine Acetylation Tissue Development Respiratory System Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Tubulin Deacetylation Cellular Response To Cycloheximide Paraxial Mesoderm Formation Cellular Response To Laminar Fluid Shear Stress Glucose Import Response To Oxidative Stress Transcription, DNA-templated RNA Biosynthetic Process Anatomical Structure Morphogenesis Positive Regulation By Host Of Viral Transcription Response To Cycloheximide Response To Organic Substance Positive Regulation Of Cellular Metabolic Process In Utero Embryonic Development N-terminal Protein Amino Acid Acetylation Renal Absorption Regulation Of Cytokine Production Erythrocyte Maturation Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Chromatin Modification Cellular Response To Fluid Shear Stress Response To Laminar Fluid Shear Stress Paraxial Mesoderm Morphogenesis Organ Development Positive Regulation Of DNA-templated Transcription, Initiation Reverse Cholesterol Transport Type I Pneumocyte Differentiation RNA Metabolic Process Regulation Of Androgen Receptor Signaling Pathway Tube Development
Tagcloud ?		2x10 56x10 5x10 apaf1 birc2 casp4 cdk2 clones disruptions ductal dysregulated e2f1 enrichment g0 investigating mcm2 messenger mia micro paca panc pancreas pancreatic pdac promise rank skp2 sub uncover	aberrant alternative arrdc3 carcinomas cpg detect ductal elp3 explore follows frequency grades hypermethylation idcs inactivate inactivation islands lower lymph matched methylated methylation mnts node pax6 promoter represents suppressor unmethylated
Tagcloud (Difference) ?		2x10 56x10 5x10 apaf1 birc2 casp4 cdk2 clones disruptions dysregulated e2f1 enrichment g0 investigating mcm2 messenger mia micro paca panc pancreas pancreatic pdac promise rank skp2 sub uncover	aberrant alternative arrdc3 carcinomas cpg detect elp3 explore follows frequency grades hypermethylation idcs inactivate inactivation islands lower lymph matched methylated methylation mnts node pax6 promoter represents suppressor unmethylated
Tagcloud (Intersection) ?		ductal