HNF1A and GATA5

Number of citations of the paper that reports this interaction (PubMedID 14715527)
0

Data Source:
HPRD (in vitro, in vivo)

		HNF1A	GATA5
Description		HNF1 homeobox A	GATA binding protein 5
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm Protein-containing Complex	Chromatin Nucleus Nucleoplasm
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Protein Dimerization Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Liver Development Regulation Of Transcription By RNA Polymerase II Insulin Secretion Pancreas Development Regulation Of Pronephros Size Renal D-glucose Absorption Glucose Homeostasis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II D-glucose Import Positive Regulation Of Transcription Initiation By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Heart Induction Aortic Valve Morphogenesis Endocardial Cushion Fusion Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Heart Development Anatomical Structure Morphogenesis Tissue Development Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Cell Differentiation Cell Fate Commitment Positive Regulation Of Notch Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cardiac Muscle Tissue Development Intestinal Epithelial Cell Differentiation Positive Regulation Of Cardiac Endothelial To Mesenchymal Transition Cellular Response To Hydrogen Peroxide Cellular Response To Nitric Oxide Cellular Response To BMP Stimulus Positive Regulation Of Apoptotic DNA Fragmentation
Pathways		Regulation of gene expression in beta cells	Factors involved in megakaryocyte development and platelet production
Drugs		D-norleucine
Diseases		Maturity onset diabetes of the young (MODY)
GWAS		Acute insulin response ( 28490609) Age at first birth ( 34211149) Apolipoprotein B levels ( 32203549) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Birth weight ( 31043758) Blood protein levels in cardiovascular risk ( 28369058) Blood urea nitrogen levels ( 29403010) C-reactive protein ( 18439548 18439552 19567438 21196492 21647738 22939635 23844046) C-reactive protein and white blood cell count ( 22788528) C-reactive protein levels ( 21300955 24763700 29403010 29878111 30388399 31622379 33339817) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Ceramide levels (C22:0) ( 32489964) Chloride levels ( 29403010) Cholesterol, total ( 20686565 24097068 25961943) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Coronary artery disease ( 28714974 29212778 32469254 33020668) Coronary heart disease ( 19198612) Gallstone disease ( 30504769) Gamma glutamyl transferase levels ( 22010049 29403010 33339817) Gamma glutamyl transpeptidase ( 21909109) Glucosuria ( 30476138) Glucosuria (moderate to severe) ( 30476138) HDL cholesterol levels ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Hemoglobin levels ( 32327693) High-sensitivity C-reactive protein levels in HIV infection ( 33095540) Homocysteine levels ( 23824729) Insulinogenic index ( 23263489) LDL cholesterol ( 19060906 20686565 24097068 25961943 30275531) LDL cholesterol levels ( 28334899 30698716 32203549) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Liver enzyme levels ( 18940312) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Longevity ( 20834067) Low density lipoprotein cholesterol levels ( 32154731 33339817) Myocardial infarction ( 33532862) N-glycan levels ( 21203500 21908519) Pancreatic cancer ( 26098869 29422604) Pancreatic ductal adenocarcinoma ( 30541042) Peak insulin response ( 28490609) Serum alkaline phosphatase levels ( 31666285 33339817 33547301) Serum alpha1-antitrypsin levels ( 26174136) Serum C-reactive protein concentration ( 32928877) Serum C-reactive protein concentration in high fat diet ( 32928877) Serum C-reactive protein concentration in low fat diet ( 32928877) Serum C-reactive protein concentration in non-obese individuals ( 32928877) Serum C-reactive protein concentration in obesity ( 32928877) Serum C-reactive protein concentration in visceral obesity (waist circumference) ( 32928877) Serum C-reactive protein concentration in visceral obesity (waist-hip ratio) ( 32928877) Serum metabolite levels (CMS) ( 31636271) Stroke ( 32693751) Total cholesterol levels ( 28334899 30275531) Type 2 diabetes ( 20581827 21573907 22885922 24509480 26818947 28869590 29632382 30297969 30718926 32499647) Type 2 diabetes (adjusted for BMI) ( 29632382) Urate levels ( 23263486 31578528) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)	Benign prostatic hyperplasia and lower urinary tract symptoms ( 30410027) Central serous retinopathy ( 31872073) Chronic central serous retinopathy ( 30073298) Hematocrit ( 32888494) Hemoglobin ( 32888494) Prostate cancer ( 23535732)
Interacting Genes		24 interacting genes: ALB BCR CDX2 CEBPA CREBBP CTNNB1 EP300 FOS GATA5 HNF1B HNF4A KAT2B MYOG NCOA1 NCOA3 PCBD1 POU2F1 RAC3 RNF14 RYR3 SRC STAT3 TLE1 TLE5	10 interacting genes: ARID5A CYSRT1 EP300 HNF1A HPCA HPCAL1 KLF2 MAGED1 PLA2G10 PPARG
Entrez ID		6927	140628
HPRD ID		00800	17029
Ensembl ID		ENSG00000135100	ENSG00000130700
Uniprot IDs		A0A0A0MTK8 E0YMI7 F5H0K0 P20823	Q9BWX5
PDB IDs		1IC8 2GYP 8PI7 8PI8 8PI9 8PIA
Enriched GO Terms of Interacting Partners?		Transcription Regulator Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Chromatin Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Protein-lysine-acetyltransferase Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Histone Acetyltransferase Activity Negative Regulation Of RNA Metabolic Process Intracellular Signal Transduction Positive Regulation Of Metabolic Process N-terminal Peptidyl-lysine Acetylation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein-containing Complex Transcription Coactivator Activity DNA-binding Transcription Factor Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Primary Metabolic Process Regulation Of Developmental Process Response To Nutrient Levels RNA Polymerase II Transcription Regulator Complex Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Cellular Response To Nutrient Levels Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Chromatin DNA Binding Animal Organ Development Positive Regulation Of Cell Differentiation Cellular Response To Oxygen-containing Compound Sequence-specific DNA Binding Nucleus DNA-binding Transcription Factor Activity Chromatin Binding Developmental Process Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process Transcription Coregulator Binding	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of T-helper 17 Type Immune Response STAT Family Protein Binding Nuclear Retinoid X Receptor Binding Erythrocyte Maturation Cellular Response To Oxygen-containing Compound Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cell Maturation Regulation Of Transcription By RNA Polymerase II Nuclear Androgen Receptor Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Macrophage Derived Foam Cell Differentiation Chromatin Positive Regulation Of RNA Metabolic Process Developmental Maturation Regulation Of T-helper 17 Type Immune Response Transcription Coregulator Binding Response To Hormone Regulation Of Cholesterol Efflux Positive Regulation Of Nucleobase-containing Compound Metabolic Process Rhythmic Process Positive Regulation Of Transcription By RNA Polymerase II Long-chain Fatty Acid Transport Regulation Of Lipid Storage Transcription Cis-regulatory Region Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Peptidyl-lysine Propionylation Regulation Of RNA Biosynthetic Process Swimming Histone Lactyltransferase (CoA-dependent) Activity Negative Regulation Of Macromolecule Biosynthetic Process Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Response To Estrogen Regulation Of Cholesterol Transport Positive Regulation Of Establishment Of Protein Localization Negative Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Histone H2B Acetyltransferase Activity Regulation Of RNA Metabolic Process Acetylation-dependent Protein Binding Peptide Butyryltransferase Activity
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