HNF1A and CDX2

Number of citations of the paper that reports this interaction (PMID 10677375)
15

Data Source:
BioGRID (pull down)
HPRD (in vivo, in vitro)

		HNF1A	CDX2
Gene Name		HNF1 homeobox A	caudal type homeobox 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Protein Complex	Condensed Nuclear Chromosome Nucleoplasm Transcriptional Repressor Complex
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity Protein Dimerization Activity	RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity
	Biological Process	Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Insulin Secretion Regulation Of Pronephros Size Renal Glucose Absorption Glucose Homeostasis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Glucose Import Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter	Negative Regulation Of Transcription From RNA Polymerase II Promoter Blood Vessel Development Trophectodermal Cell Differentiation Transcription From RNA Polymerase II Promoter Positive Regulation Of Cell Proliferation Endosome To Lysosome Transport Organ Morphogenesis Anterior/posterior Pattern Specification Somatic Stem Cell Maintenance Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription, DNA-templated Labyrinthine Layer Development
Pathways		Regulation of beta-cell development Regulation of gene expression in beta cells	Peptide hormone metabolism Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Incretin synthesis, secretion, and inactivation
Drugs
Diseases
GWAS		C-reactive protein ( 19567438 21647738 18439548 18439552 21196492 21300955 22939635) C-reactive protein and white blood cell count ( 22788528) Cholesterol, total ( 20686565) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Coronary heart disease ( 19198612) Gamma gluatamyl transferase levels ( 22010049) Gamma glutamyl transpeptidase ( 21909109) LDL cholesterol ( 19060906 20686565) Liver enzyme levels ( 18940312) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Longevity ( 20834067) N-glycan levels ( 21203500) Type 2 diabetes ( 21573907 20581827) Urate levels ( 23263486)
Protein-Protein Interactions		21 interactors: AES ALB BCR CDX2 CEBPA CREBBP CTNNB1 EP300 FOS GATA5 HNF1B HNF4A KAT2B PCBD1 POU2F1 RAC3 RNF14 RYR3 SRC STAT3 TLE1	13 interactors: ACAT2 CDK2 CREBBP EP300 GSK3B HNF1A MAPK1 MAPK14 PAX6 SMARCA4 SMARCB1 SMARCD1 UBB
Entrez ID		6927	1045
HPRD ID		00800	02622
Ensembl ID		ENSG00000135100
Uniprot IDs		F5H5U3 P20823	Q99626
PDB IDs		1IC8 2GYP
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Metabolic Process Response To Organic Substance Positive Regulation Of Cellular Metabolic Process RNA Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Cellular Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Organ Morphogenesis Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription N-terminal Peptidyl-lysine Acetylation Negative Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Response To Hormone Negative Regulation Of Gene Expression Response To Steroid Hormone Negative Regulation Of Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Anatomical Structure Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Anatomical Structure Morphogenesis Organ Development Intracellular Receptor Signaling Pathway Response To Lipid Response To Organic Cyclic Compound Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Developmental Process Nitrogen Compound Metabolic Process Multicellular Organismal Development Cell Communication System Development	Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Regulation Of Cellular Response To Heat Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Modification Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Transcription, DNA-templated Positive Regulation By Host Of Viral Transcription Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Chromatin Organization Cellular Response To Heat Nucleosome Disassembly Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cell Cycle Developmental Process Cellular Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Organ Morphogenesis Response To Heat Chromosome Organization Transcription, DNA-templated Regulation Of Wnt Signaling Pathway Cell Cycle Process RNA Biosynthetic Process Anatomical Structure Morphogenesis Interaction With Symbiont Nucleobase-containing Compound Metabolic Process N-terminal Peptidyl-lysine Acetylation Embryo Development Response To Stress Multicellular Organismal Development Cellular Macromolecule Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Macromolecule Biosynthetic Process Anatomical Structure Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Positive Regulation Of Viral Transcription Cellular Nitrogen Compound Metabolic Process Innate Immune Response
Tagcloud ?		2x10 56x10 5x10 apaf1 birc2 casp4 cdk2 clones disruptions ductal dysregulated e2f1 enrichment g0 investigating mcm2 messenger mia micro paca panc pancreas pancreatic pdac promise rank skp2 sub uncover	blastocyst blastocysts buffalo caspase3 caspase6 caspase7 cleave cleaving cloning competence developmental dnmt1 dnmt3a ec embryos epigenetics h3k27me3 h3k9ac handmade hdac1 hmc ivf lc nanog oct4 pluripotency produced sox2 trophectoderm
Tagcloud (Difference) ?		2x10 56x10 5x10 apaf1 birc2 casp4 cdk2 clones disruptions ductal dysregulated e2f1 enrichment g0 investigating mcm2 messenger mia micro paca panc pancreas pancreatic pdac promise rank skp2 sub uncover	blastocyst blastocysts buffalo caspase3 caspase6 caspase7 cleave cleaving cloning competence developmental dnmt1 dnmt3a ec embryos epigenetics h3k27me3 h3k9ac handmade hdac1 hmc ivf lc nanog oct4 pluripotency produced sox2 trophectoderm
Tagcloud (Intersection) ?