HNF1A and CDX2

Number of citations of the paper that reports this interaction (PubMedID 10677375)
29

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		HNF1A	CDX2
Description		HNF1 homeobox A	caudal type homeobox 2
Image
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm Protein-containing Complex	Chromatin Condensed Nuclear Chromosome Nucleus Nucleoplasm Transcription Repressor Complex Protein-containing Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Protein Dimerization Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Methyl-CpG Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Liver Development Regulation Of Transcription By RNA Polymerase II Insulin Secretion Pancreas Development Regulation Of Pronephros Size Renal D-glucose Absorption Glucose Homeostasis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II D-glucose Import Positive Regulation Of Transcription Initiation By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Blood Vessel Development Blastocyst Development Trophectodermal Cell Differentiation Placenta Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Pattern Specification Process Positive Regulation Of Cell Population Proliferation Endosome To Lysosome Transport Embryonic Pattern Specification Animal Organ Morphogenesis Anterior/posterior Axis Specification Anterior/posterior Pattern Specification Regulation Of Somitogenesis Cell Differentiation Somatic Stem Cell Population Maintenance Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Development Stem Cell Differentiation Intestinal Epithelial Cell Differentiation Labyrinthine Layer Development
Pathways		Regulation of gene expression in beta cells	Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
Drugs		D-norleucine
Diseases		Maturity onset diabetes of the young (MODY)
GWAS		Acute insulin response ( 28490609) Age at first birth ( 34211149) Apolipoprotein B levels ( 32203549) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Birth weight ( 31043758) Blood protein levels in cardiovascular risk ( 28369058) Blood urea nitrogen levels ( 29403010) C-reactive protein ( 18439548 18439552 19567438 21196492 21647738 22939635 23844046) C-reactive protein and white blood cell count ( 22788528) C-reactive protein levels ( 21300955 24763700 29403010 29878111 30388399 31622379 33339817) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Ceramide levels (C22:0) ( 32489964) Chloride levels ( 29403010) Cholesterol, total ( 20686565 24097068 25961943) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Coronary artery disease ( 28714974 29212778 32469254 33020668) Coronary heart disease ( 19198612) Gallstone disease ( 30504769) Gamma glutamyl transferase levels ( 22010049 29403010 33339817) Gamma glutamyl transpeptidase ( 21909109) Glucosuria ( 30476138) Glucosuria (moderate to severe) ( 30476138) HDL cholesterol levels ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Hemoglobin levels ( 32327693) High-sensitivity C-reactive protein levels in HIV infection ( 33095540) Homocysteine levels ( 23824729) Insulinogenic index ( 23263489) LDL cholesterol ( 19060906 20686565 24097068 25961943 30275531) LDL cholesterol levels ( 28334899 30698716 32203549) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Liver enzyme levels ( 18940312) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Longevity ( 20834067) Low density lipoprotein cholesterol levels ( 32154731 33339817) Myocardial infarction ( 33532862) N-glycan levels ( 21203500 21908519) Pancreatic cancer ( 26098869 29422604) Pancreatic ductal adenocarcinoma ( 30541042) Peak insulin response ( 28490609) Serum alkaline phosphatase levels ( 31666285 33339817 33547301) Serum alpha1-antitrypsin levels ( 26174136) Serum C-reactive protein concentration ( 32928877) Serum C-reactive protein concentration in high fat diet ( 32928877) Serum C-reactive protein concentration in low fat diet ( 32928877) Serum C-reactive protein concentration in non-obese individuals ( 32928877) Serum C-reactive protein concentration in obesity ( 32928877) Serum C-reactive protein concentration in visceral obesity (waist circumference) ( 32928877) Serum C-reactive protein concentration in visceral obesity (waist-hip ratio) ( 32928877) Serum metabolite levels (CMS) ( 31636271) Stroke ( 32693751) Total cholesterol levels ( 28334899 30275531) Type 2 diabetes ( 20581827 21573907 22885922 24509480 26818947 28869590 29632382 30297969 30718926 32499647) Type 2 diabetes (adjusted for BMI) ( 29632382) Urate levels ( 23263486 31578528) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)	Body mass index ( 26426971) Monocyte count ( 27863252) Pancreatic cancer ( 25086665)
Interacting Genes		24 interacting genes: ALB BCR CDX2 CEBPA CREBBP CTNNB1 EP300 FOS GATA5 HNF1B HNF4A KAT2B MYOG NCOA1 NCOA3 PCBD1 POU2F1 RAC3 RNF14 RYR3 SRC STAT3 TLE1 TLE5	18 interacting genes: ACAT2 ATM CDK2 CFAP206 CREBBP DNMT3L EP300 GSK3B HNF1A KRTAP4-12 MAPK1 MAPK14 MRE11 PAX6 SMARCA4 SMARCB1 SMARCD1 UBB
Entrez ID		6927	1045
HPRD ID		00800	02622
Ensembl ID		ENSG00000135100	ENSG00000165556
Uniprot IDs		A0A0A0MTK8 E0YMI7 F5H0K0 P20823	Q99626
PDB IDs		1IC8 2GYP 8PI7 8PI8 8PI9 8PIA	5LTY 6ES2 6ES3 7Q4N
Enriched GO Terms of Interacting Partners?		Transcription Regulator Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Chromatin Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Protein-lysine-acetyltransferase Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Histone Acetyltransferase Activity Negative Regulation Of RNA Metabolic Process Intracellular Signal Transduction Positive Regulation Of Metabolic Process N-terminal Peptidyl-lysine Acetylation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein-containing Complex Transcription Coactivator Activity DNA-binding Transcription Factor Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Primary Metabolic Process Regulation Of Developmental Process Response To Nutrient Levels RNA Polymerase II Transcription Regulator Complex Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Cellular Response To Nutrient Levels Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Chromatin DNA Binding Animal Organ Development Positive Regulation Of Cell Differentiation Cellular Response To Oxygen-containing Compound Sequence-specific DNA Binding Nucleus DNA-binding Transcription Factor Activity Chromatin Binding Developmental Process Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process Transcription Coregulator Binding	Chromatin Remodeling Positive Regulation Of DNA Metabolic Process Positive Regulation Of Double-strand Break Repair Regulation Of Cellular Response To Heat Regulation Of Cellular Response To Stress Chromatin Organization Positive Regulation Of Macromolecule Metabolic Process Regulation Of Chromosome Organization Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA Repair Regulation Of Double-strand Break Repair P53 Binding Regulation Of DNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of DNA Repair Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Myoblast Differentiation Regulation Of Cell Cycle Phase Transition Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of RNA Metabolic Process Positive Regulation Of Gene Expression, Epigenetic NpBAF Complex Regulation Of Mitotic Cell Cycle RSC-type Complex NBAF Complex Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of RNA Biosynthetic Process Meiosis I Cell Cycle Process Positive Regulation Of Macromolecule Biosynthetic Process Host-mediated Activation Of Viral Transcription Regulation Of Organelle Organization Histone H3K27 Acetyltransferase Activity Regulation Of Myoblast Differentiation Nucleosome Disassembly Positive Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Protein-DNA Complex Disassembly Regulation Of Primary Metabolic Process Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of RNA Metabolic Process DNA Damage Checkpoint Signaling Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Positive Regulation Of Glucose Mediated Signaling Pathway
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