HNF1A and BCR

Number of citations of the paper that reports this interaction (PMID 16442529)
1

Data Source:
HPRD (in vivo)

		HNF1A	BCR
Gene Name		HNF1 homeobox A	breakpoint cluster region
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Protein Complex	Cytosol Postsynaptic Density Membrane Cell Junction Protein Complex Postsynaptic Membrane Extracellular Vesicular Exosome
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity Protein Dimerization Activity	Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding ATP Binding Kinase Activity Enzyme Binding Rac GTPase Activator Activity
	Biological Process	Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Insulin Secretion Regulation Of Pronephros Size Renal Glucose Absorption Glucose Homeostasis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Glucose Import Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter	Protein Phosphorylation Signal Transduction Small GTPase Mediated Signal Transduction Brain Development Peptidyl-tyrosine Phosphorylation Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Response To Lipopolysaccharide Positive Regulation Of Rac GTPase Activity Inner Ear Morphogenesis Negative Regulation Of Neutrophil Degranulation Protein Autophosphorylation Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Neuromuscular Process Controlling Balance Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Cell Cycle
Pathways		Regulation of beta-cell development Regulation of gene expression in beta cells	Rho GTPase cycle Signaling by FGFR in disease Signaling by Rho GTPases Signaling by FGFR1 mutants Signaling by FGFR mutants Signaling by FGFR1 fusion mutants
Drugs
Diseases
GWAS		C-reactive protein ( 19567438 21647738 18439548 18439552 21196492 21300955 22939635) C-reactive protein and white blood cell count ( 22788528) Cholesterol, total ( 20686565) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Coronary heart disease ( 19198612) Gamma gluatamyl transferase levels ( 22010049) Gamma glutamyl transpeptidase ( 21909109) LDL cholesterol ( 19060906 20686565) Liver enzyme levels ( 18940312) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Longevity ( 20834067) N-glycan levels ( 21203500) Type 2 diabetes ( 21573907 20581827) Urate levels ( 23263486)	Height ( 18391951) Immune response to smallpox vaccine (IL-6) ( 22542470)
Protein-Protein Interactions		21 interactors: AES ALB BCR CDX2 CEBPA CREBBP CTNNB1 EP300 FOS GATA5 HNF1B HNF4A KAT2B PCBD1 POU2F1 RAC3 RNF14 RYR3 SRC STAT3 TLE1	44 interactors: ABL1 ABL2 APBA3 BLK CBL CDC42 CRK CRKL DLG1 DOK1 ERCC3 FES GRB10 GRB2 HCK HNF1A IGSF21 IRS1 JAK2 LNX1 MAP4K5 MLLT4 PIK3CG PLCG1 PTPN1 PTPN11 PTPN6 RAC1 RASA1 RHOA SFN SHC1 SRC STUB1 TP53 TSG101 UNC119 VAV1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ
Entrez ID		6927	613
HPRD ID		00800	01044
Ensembl ID		ENSG00000135100	ENSG00000186716
Uniprot IDs		F5H5U3 P20823	P11274
PDB IDs		1IC8 2GYP	1K1F 2AIN
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Metabolic Process Response To Organic Substance Positive Regulation Of Cellular Metabolic Process RNA Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Cellular Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Organ Morphogenesis Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription N-terminal Peptidyl-lysine Acetylation Negative Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Response To Hormone Negative Regulation Of Gene Expression Response To Steroid Hormone Negative Regulation Of Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Anatomical Structure Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Anatomical Structure Morphogenesis Organ Development Intracellular Receptor Signaling Pathway Response To Lipid Response To Organic Cyclic Compound Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Developmental Process Nitrogen Compound Metabolic Process Multicellular Organismal Development Cell Communication System Development	Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Signaling Signaling Cell Communication Intracellular Signal Transduction Positive Regulation Of Transport Regulation Of Cellular Localization Signal Transduction Regulation Of Phosphorus Metabolic Process Regulation Of Phosphorylation Blood Coagulation Hemostasis Regulation Of Intracellular Transport Regulation Of Organelle Organization Regulation Of Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Establishment Of Protein Localization Innate Immune Response ERBB Signaling Pathway Immune Response Cellular Response To Organic Substance Regulation Of Body Fluid Levels Regulation Of Catalytic Activity Regulation Of Cellular Component Organization Cellular Response To Peptide Hormone Stimulus Cellular Response To Stimulus Cellular Response To Peptide Cell Surface Receptor Signaling Pathway Regulation Of Protein Localization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Organonitrogen Compound Neurotrophin Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Wound Healing Regulation Of Protein Kinase Activity Positive Regulation Of Organelle Organization Positive Regulation Of Intracellular Transport Response To Organic Substance Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Protein Phosphorylation Response To Stress Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Transferase Activity Fc Receptor Signaling Pathway
Tagcloud ?		2x10 56x10 5x10 apaf1 birc2 casp4 cdk2 clones disruptions ductal dysregulated e2f1 enrichment g0 investigating mcm2 messenger mia micro paca panc pancreas pancreatic pdac promise rank skp2 sub uncover	absent agglutinin bm centers centroblasts centrocytes chimeric clusters fdc follicles follicular gc gcs germinal grafts hosts humoral lt ltbeta ltbetar lymphotoxin networks peanut pna radioresistant reciprocal reconstituted splenic tnfrp55
Tagcloud (Difference) ?		2x10 56x10 5x10 apaf1 birc2 casp4 cdk2 clones disruptions ductal dysregulated e2f1 enrichment g0 investigating mcm2 messenger mia micro paca panc pancreas pancreatic pdac promise rank skp2 sub uncover	absent agglutinin bm centers centroblasts centrocytes chimeric clusters fdc follicles follicular gc gcs germinal grafts hosts humoral lt ltbeta ltbetar lymphotoxin networks peanut pna radioresistant reciprocal reconstituted splenic tnfrp55
Tagcloud (Intersection) ?